Blood–brain barrier disruption: a pervasive driver and mechanistic link between traumatic brain injury and Alzheimer's disease

Abstract Traumatic brain injury (TBI) has emerged as a significant risk factor for Alzheimer’s disease (AD), a complex and devastating neurodegenerative disorder characterized by progressive cognitive decline and memory loss. Both conditions share a common feature: blood‒brain barrier (BBB) dysfunct...

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Bibliographic Details
Main Authors: Bryan Sun, Lulin Li, Odette A. Harris, Jian Luo
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Translational Neurodegeneration
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Online Access:https://doi.org/10.1186/s40035-025-00478-5
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