Genomics of Cancer and a New Era for Cancer Prevention.
A primary justification for dedicating substantial amounts of research funding to large-scale cancer genomics projects of both somatic and germline DNA is that the biological insights will lead to new treatment targets and strategies for cancer therapy. While it is too early to judge the success of...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-11-01
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| Series: | PLoS Genetics |
| Online Access: | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005522&type=printable |
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| author | Paul Brennan Christopher P Wild |
| author_facet | Paul Brennan Christopher P Wild |
| author_sort | Paul Brennan |
| collection | DOAJ |
| description | A primary justification for dedicating substantial amounts of research funding to large-scale cancer genomics projects of both somatic and germline DNA is that the biological insights will lead to new treatment targets and strategies for cancer therapy. While it is too early to judge the success of these projects in terms of clinical breakthroughs, an alternative rationale is that new genomics techniques can be used to reduce the overall burden of cancer by prevention of new cases occurring and also by detecting them earlier. In particular, it is now becoming apparent that studying the genomic profile of tumors can help to identify new carcinogens and may subsequently result in implementing strategies that limit exposure. In parallel, it may be feasible to utilize genomic biomarkers to identify cancers at an earlier and more treatable stage using screening or other early detection approaches based on prediagnostic biospecimens. While the potential for these techniques is large, their successful outcome will depend on international collaboration and planning similar to that of recent sequencing initiatives. |
| format | Article |
| id | doaj-art-9f912192b29e4e2e84f50cac1521602f |
| institution | OA Journals |
| issn | 1553-7390 1553-7404 |
| language | English |
| publishDate | 2015-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Genetics |
| spelling | doaj-art-9f912192b29e4e2e84f50cac1521602f2025-08-20T02:22:40ZengPublic Library of Science (PLoS)PLoS Genetics1553-73901553-74042015-11-011111e100552210.1371/journal.pgen.1005522Genomics of Cancer and a New Era for Cancer Prevention.Paul BrennanChristopher P WildA primary justification for dedicating substantial amounts of research funding to large-scale cancer genomics projects of both somatic and germline DNA is that the biological insights will lead to new treatment targets and strategies for cancer therapy. While it is too early to judge the success of these projects in terms of clinical breakthroughs, an alternative rationale is that new genomics techniques can be used to reduce the overall burden of cancer by prevention of new cases occurring and also by detecting them earlier. In particular, it is now becoming apparent that studying the genomic profile of tumors can help to identify new carcinogens and may subsequently result in implementing strategies that limit exposure. In parallel, it may be feasible to utilize genomic biomarkers to identify cancers at an earlier and more treatable stage using screening or other early detection approaches based on prediagnostic biospecimens. While the potential for these techniques is large, their successful outcome will depend on international collaboration and planning similar to that of recent sequencing initiatives.https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005522&type=printable |
| spellingShingle | Paul Brennan Christopher P Wild Genomics of Cancer and a New Era for Cancer Prevention. PLoS Genetics |
| title | Genomics of Cancer and a New Era for Cancer Prevention. |
| title_full | Genomics of Cancer and a New Era for Cancer Prevention. |
| title_fullStr | Genomics of Cancer and a New Era for Cancer Prevention. |
| title_full_unstemmed | Genomics of Cancer and a New Era for Cancer Prevention. |
| title_short | Genomics of Cancer and a New Era for Cancer Prevention. |
| title_sort | genomics of cancer and a new era for cancer prevention |
| url | https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1005522&type=printable |
| work_keys_str_mv | AT paulbrennan genomicsofcancerandaneweraforcancerprevention AT christopherpwild genomicsofcancerandaneweraforcancerprevention |