Impact of nonsynonymous single nucleotide polymorphisms in PROCR gene on protein stability and thrombotic risk: a molecular dynamic approach

Impact of nonsynonymous single nucleotide polymorphisms in PROCR gene on protein stability and thrombotic risk: a molecular dynamic approach

IntroductionThrombosis is a serious vascular disorder influenced by genetic factors, including nonsynonymous single nucleotide polymorphisms (nsSNPs) in the PROCR gene, which encodes the endothelial protein C receptor (EPCR). These mutations may disrupt EPCR stability and impair its anticoagulant fu...

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Main Authors: Hytham Ahmed Abuagla, Khalid Mohamed Adam, Mohamed E. Elangeeb, Elsadig Mohamed Ahmed, Elshazali W. Ali, Ali M. Edris, Abubakr Ali Elamin MohamedAhmed, Elmoiz Idris Eltieb, Tarig Babikir Algak Khalid, Bahaeldin K. Elamin, Hiba Mahgoub Ali Osman, Ebtehal Salih Idris
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Genetics
Subjects:
thrombosis
PROCR
nsSNPs
EPCR
protein stability
molecular dynamics
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2025.1580993/full
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