Morphological variations of the interatrial septum and potential implications in equine cardiology
Abstract The interatrial septum morphology, shaped by the septum primum and secundum fusion, results in the formation of the fossa ovalis (FO) and its limbus. Incomplete fusion can lead to a patent foramen ovale (PFO), while complete fusion may produce septal ridges and pouches (SPs), with SPs in hu...
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Nature Portfolio
2025-05-01
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| Online Access: | https://doi.org/10.1038/s41598-025-01387-3 |
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| author | Lara Ibrahim Ingrid Vernemmen Eva Buschmann Gunther van Loon Pieter Cornillie |
| author_facet | Lara Ibrahim Ingrid Vernemmen Eva Buschmann Gunther van Loon Pieter Cornillie |
| author_sort | Lara Ibrahim |
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| description | Abstract The interatrial septum morphology, shaped by the septum primum and secundum fusion, results in the formation of the fossa ovalis (FO) and its limbus. Incomplete fusion can lead to a patent foramen ovale (PFO), while complete fusion may produce septal ridges and pouches (SPs), with SPs in humans linked to ischemic stroke and atrial arrhythmias. In horses, atrial tachycardia and fibrillation often originate near the FO. This study examines adult equine interatrial septum morphology to enhance understanding the region and guide electrophysiological interventions for equine cardiac arrhythmias. Post-mortem examinations of 62 adult equine hearts, assessed the interatrial septum morphology from both right and left sides, measuring the dimensions of the FO and the craniocaudal length, and dorsoventral height of the SPs. Histological analysis at selected septal locations evaluated the wall’s thickness and composition. Significant morphological variations were observed, particularly the consistent presence of right-sided SP. The septum wall comprises three layers, with the central layer containing cardiomyocytes in varied orientations, interspersed with fibroadipose tissue, features potentially contributing to atrial arrhythmias. Understanding the equine interatrial septum morphology is important for optimizing transseptal puncture outcomes, by facilitating accurate intracardiac echocardiography interpretation, guiding precise puncture site selection and improving procedural safety and efficacy. |
| format | Article |
| id | doaj-art-9f7f323ffa7b43d892d3a65353bfde59 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-9f7f323ffa7b43d892d3a65353bfde592025-08-20T03:53:58ZengNature PortfolioScientific Reports2045-23222025-05-0115111110.1038/s41598-025-01387-3Morphological variations of the interatrial septum and potential implications in equine cardiologyLara Ibrahim0Ingrid Vernemmen1Eva Buschmann2Gunther van Loon3Pieter Cornillie4Department of Morphology, Imaging, Orthopedics, Rehabilitation and Nutrition, Faculty of Veterinary Medicine, Ghent UniversityEquine Cardioteam Ghent, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent UniversityEquine Cardioteam Ghent, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent UniversityEquine Cardioteam Ghent, Department of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent UniversityDepartment of Morphology, Imaging, Orthopedics, Rehabilitation and Nutrition, Faculty of Veterinary Medicine, Ghent UniversityAbstract The interatrial septum morphology, shaped by the septum primum and secundum fusion, results in the formation of the fossa ovalis (FO) and its limbus. Incomplete fusion can lead to a patent foramen ovale (PFO), while complete fusion may produce septal ridges and pouches (SPs), with SPs in humans linked to ischemic stroke and atrial arrhythmias. In horses, atrial tachycardia and fibrillation often originate near the FO. This study examines adult equine interatrial septum morphology to enhance understanding the region and guide electrophysiological interventions for equine cardiac arrhythmias. Post-mortem examinations of 62 adult equine hearts, assessed the interatrial septum morphology from both right and left sides, measuring the dimensions of the FO and the craniocaudal length, and dorsoventral height of the SPs. Histological analysis at selected septal locations evaluated the wall’s thickness and composition. Significant morphological variations were observed, particularly the consistent presence of right-sided SP. The septum wall comprises three layers, with the central layer containing cardiomyocytes in varied orientations, interspersed with fibroadipose tissue, features potentially contributing to atrial arrhythmias. Understanding the equine interatrial septum morphology is important for optimizing transseptal puncture outcomes, by facilitating accurate intracardiac echocardiography interpretation, guiding precise puncture site selection and improving procedural safety and efficacy.https://doi.org/10.1038/s41598-025-01387-3Septal pouchRidgeTranseptal punctureFossa ovalisArrhythmiaHorse |
| spellingShingle | Lara Ibrahim Ingrid Vernemmen Eva Buschmann Gunther van Loon Pieter Cornillie Morphological variations of the interatrial septum and potential implications in equine cardiology Scientific Reports Septal pouch Ridge Transeptal puncture Fossa ovalis Arrhythmia Horse |
| title | Morphological variations of the interatrial septum and potential implications in equine cardiology |
| title_full | Morphological variations of the interatrial septum and potential implications in equine cardiology |
| title_fullStr | Morphological variations of the interatrial septum and potential implications in equine cardiology |
| title_full_unstemmed | Morphological variations of the interatrial septum and potential implications in equine cardiology |
| title_short | Morphological variations of the interatrial septum and potential implications in equine cardiology |
| title_sort | morphological variations of the interatrial septum and potential implications in equine cardiology |
| topic | Septal pouch Ridge Transeptal puncture Fossa ovalis Arrhythmia Horse |
| url | https://doi.org/10.1038/s41598-025-01387-3 |
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