Gorham-Stout Disease. Case report and narrative literature review
Gorham’s disease, also known as vanishing bone disease, is a rare condition of unknown etiology characterized by progressive destruction and bone resorption. The disease can affect any part of the skeleton, but it is more frequently found in the head and neck, upper extremities, pelvis, humerus, and...
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| Language: | English |
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Publymed
2025-02-01
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| Series: | Annali di Stomatologia |
| Online Access: | https://www.annalidistomatologia.eu/ads/article/view/383/399 |
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| author | Federici Francesca Romana Giovanni Barbini Gianluca Pingitore Gabriele Miccoli Massimo Galli |
| author_facet | Federici Francesca Romana Giovanni Barbini Gianluca Pingitore Gabriele Miccoli Massimo Galli |
| author_sort | Federici Francesca Romana |
| collection | DOAJ |
| description | Gorham’s disease, also known as vanishing bone disease, is a rare condition of unknown etiology characterized by progressive destruction and bone resorption. The disease can affect any part of the skeleton, but it is more frequently found in the head and neck, upper extremities, pelvis, humerus, and the axial skeleton. The mechanism of bone resorption is unclear; however, osteolytic lesions exhibit localized endothelial proliferation of lymphatic vessels. The diagnosis is based on clinical, radiological, and histological features after excluding other infectious, inflammatory, endocrinologic, and neoplastic etiologies. The medical treatment for Gorham’s disease includes anti-osteoclastic medications (bisphosphonates), alpha-2b interferon, sirolimus, and propranolol. Radiation therapy acts by inducing sclerosis of proliferating vascular tissue within the bone. The surgical treatment options include resection of the lesion and reconstruction using bone grafts and/or prostheses. In this paper, we present a case of Gorham’s disease affecting the right maxilla, alveolar process, zygoma, and floor of the orbit in a 67-year-old female. At the onset of the disease, the clinical manifestation was mobility of the upper right molars, mimicking a periodontal disease, followed, after some weeks, by increased diplopia already present. The patient received medical treatment with Zoledronic acid, vitamin D, and calcium carbonate, which proved effective in controlling the disease’s progression for 12 months. |
| format | Article |
| id | doaj-art-9f7ad563e8524491b573d07a4ffc934d |
| institution | DOAJ |
| issn | 1971-1441 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Publymed |
| record_format | Article |
| series | Annali di Stomatologia |
| spelling | doaj-art-9f7ad563e8524491b573d07a4ffc934d2025-08-20T03:08:28ZengPublymedAnnali di Stomatologia1971-14412025-02-0116212613810.59987/ads/2025.2.126-138ads2502-126-138Gorham-Stout Disease. Case report and narrative literature reviewFederici Francesca Romana0Giovanni Barbini1Gianluca Pingitore2Gabriele Miccoli3Massimo Galli4Department of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, ItalyOral and Maxillofacial Surgery, San Camillo-Forlanini Hospital, Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, ItalyDepartment of Oral and Maxillofacial Sciences, Sapienza University of Rome, Rome, ItalyGorham’s disease, also known as vanishing bone disease, is a rare condition of unknown etiology characterized by progressive destruction and bone resorption. The disease can affect any part of the skeleton, but it is more frequently found in the head and neck, upper extremities, pelvis, humerus, and the axial skeleton. The mechanism of bone resorption is unclear; however, osteolytic lesions exhibit localized endothelial proliferation of lymphatic vessels. The diagnosis is based on clinical, radiological, and histological features after excluding other infectious, inflammatory, endocrinologic, and neoplastic etiologies. The medical treatment for Gorham’s disease includes anti-osteoclastic medications (bisphosphonates), alpha-2b interferon, sirolimus, and propranolol. Radiation therapy acts by inducing sclerosis of proliferating vascular tissue within the bone. The surgical treatment options include resection of the lesion and reconstruction using bone grafts and/or prostheses. In this paper, we present a case of Gorham’s disease affecting the right maxilla, alveolar process, zygoma, and floor of the orbit in a 67-year-old female. At the onset of the disease, the clinical manifestation was mobility of the upper right molars, mimicking a periodontal disease, followed, after some weeks, by increased diplopia already present. The patient received medical treatment with Zoledronic acid, vitamin D, and calcium carbonate, which proved effective in controlling the disease’s progression for 12 months.https://www.annalidistomatologia.eu/ads/article/view/383/399 |
| spellingShingle | Federici Francesca Romana Giovanni Barbini Gianluca Pingitore Gabriele Miccoli Massimo Galli Gorham-Stout Disease. Case report and narrative literature review Annali di Stomatologia |
| title | Gorham-Stout Disease. Case report and narrative literature review |
| title_full | Gorham-Stout Disease. Case report and narrative literature review |
| title_fullStr | Gorham-Stout Disease. Case report and narrative literature review |
| title_full_unstemmed | Gorham-Stout Disease. Case report and narrative literature review |
| title_short | Gorham-Stout Disease. Case report and narrative literature review |
| title_sort | gorham stout disease case report and narrative literature review |
| url | https://www.annalidistomatologia.eu/ads/article/view/383/399 |
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