PNPLA3 I148M variant links to adverse metabolic traits in MASLD during fasting and feeding

PNPLA3 I148M variant links to adverse metabolic traits in MASLD during fasting and feeding

Background & Aims: The PNPLA3 rs738409 polymorphism is the most abundant genetic risk factor associated with progression of metabolic dysfunction-associated steatotic liver disease (MASLD) to steatohepatitis (MASH) and fibrosis. Although fasting and feeding affect PNPLA3 expression, molecula...

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Main Authors: Lina Jegodzinski, Lorena Rudolph, Darko Castven, Friedhelm Sayk, Ashok Kumar Rout, Bandik Föh, Laura Hölzen, Svenja Meyhöfer, Andrea Schenk, Susanne N. Weber, Monika Rau, Sebastian M. Meyhöfer, Jörn M. Schattenberg, Marcin Krawczyk, Andreas Geier, Alvaro Mallagaray, Ulrich L. Günther, Jens U. Marquardt
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:JHEP Reports
Subjects:
PNPLA3
Fasting
MASLD
NMR-proteometabolomics
Lipoproteins
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555925001284
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