Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment using synthesized multi-contrast polarization-sensitive optical coherence tomography
Abstract Retinal pigment epithelium (RPE) melanin thickness maps, derived from multi-contrast images—including the degree of polarization uniformity (DOPU), optical coherence tomography (OCT) angiography, and the attenuation coefficient—are obtained using multi-contrast polarization-sensitive OCT (P...
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Nature Portfolio
2025-07-01
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| Online Access: | https://doi.org/10.1038/s41598-025-09302-6 |
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| author | Kosei Yanagida Masahiro Miura Hidetaka Noma Toshihiro Mino Shinnosuke Azuma Thitiya Seesan Shuichi Makita Yoshiaki Yasuno |
| author_facet | Kosei Yanagida Masahiro Miura Hidetaka Noma Toshihiro Mino Shinnosuke Azuma Thitiya Seesan Shuichi Makita Yoshiaki Yasuno |
| author_sort | Kosei Yanagida |
| collection | DOAJ |
| description | Abstract Retinal pigment epithelium (RPE) melanin thickness maps, derived from multi-contrast images—including the degree of polarization uniformity (DOPU), optical coherence tomography (OCT) angiography, and the attenuation coefficient—are obtained using multi-contrast polarization-sensitive OCT (PS-OCT). These maps have demonstrated utility for three-dimensional assessment of changes in melanin within the RPE (RPE-melanin). While both OCT angiography and the attenuation coefficient can be derived from conventional OCT, measuring the DOPU requires PS-OCT, which is not available on standard commercial OCT systems. To overcome this limitation, we utilized a convolutional neural network to generate DOPU-like images from standard OCT images and used these to calculate a synthesized RPE-melanin thickness map. We evaluated 22 eyes from 20 patients with serous pigment epithelial detachment (PED) secondary to age-related macular degeneration. Both original and synthesized RPE-melanin thickness maps were calculated from multi-contrast PS-OCT datasets. Active RPE lesions were defined as areas with RPE-melanin thickness of ≥ 70 μm (originalRPE70 and synRPE70 for the original and synthesized maps, respectively). Both synthesized and original RPE-melanin thickness maps closely resembled near-infrared autofluorescence imaging. Furthermore, both the originalRPE70 area and synRPE70 area were significantly positively correlated with the PED volume. Synthesized RPE-melanin thickness maps may be useful for clinical quantification of RPE-melanin. |
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| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-07-01 |
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| spelling | doaj-art-9f75e090609249e39e6f7a8724bf14c02025-08-20T03:46:01ZengNature PortfolioScientific Reports2045-23222025-07-0115111010.1038/s41598-025-09302-6Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment using synthesized multi-contrast polarization-sensitive optical coherence tomographyKosei Yanagida0Masahiro Miura1Hidetaka Noma2Toshihiro Mino3Shinnosuke Azuma4Thitiya Seesan5Shuichi Makita6Yoshiaki Yasuno7Department of Ophthalmology, Tokyo Medical University, Ibaraki Medical CenterDepartment of Ophthalmology, Tokyo Medical University, Ibaraki Medical CenterDepartment of Ophthalmology, Tokyo Medical University, Ibaraki Medical CenterTopcon CorporationTopcon CorporationComputational Optics Group, University of TsukubaDepartment of Ophthalmology, Tokyo Medical University, Ibaraki Medical CenterDepartment of Ophthalmology, Tokyo Medical University, Ibaraki Medical CenterAbstract Retinal pigment epithelium (RPE) melanin thickness maps, derived from multi-contrast images—including the degree of polarization uniformity (DOPU), optical coherence tomography (OCT) angiography, and the attenuation coefficient—are obtained using multi-contrast polarization-sensitive OCT (PS-OCT). These maps have demonstrated utility for three-dimensional assessment of changes in melanin within the RPE (RPE-melanin). While both OCT angiography and the attenuation coefficient can be derived from conventional OCT, measuring the DOPU requires PS-OCT, which is not available on standard commercial OCT systems. To overcome this limitation, we utilized a convolutional neural network to generate DOPU-like images from standard OCT images and used these to calculate a synthesized RPE-melanin thickness map. We evaluated 22 eyes from 20 patients with serous pigment epithelial detachment (PED) secondary to age-related macular degeneration. Both original and synthesized RPE-melanin thickness maps were calculated from multi-contrast PS-OCT datasets. Active RPE lesions were defined as areas with RPE-melanin thickness of ≥ 70 μm (originalRPE70 and synRPE70 for the original and synthesized maps, respectively). Both synthesized and original RPE-melanin thickness maps closely resembled near-infrared autofluorescence imaging. Furthermore, both the originalRPE70 area and synRPE70 area were significantly positively correlated with the PED volume. Synthesized RPE-melanin thickness maps may be useful for clinical quantification of RPE-melanin.https://doi.org/10.1038/s41598-025-09302-6Polarization-sensitive optical coherence tomographyConvolutional neural networkRetinal pigment epitheliumMelaninAge-related macular degenerationPigment epithelial detachment |
| spellingShingle | Kosei Yanagida Masahiro Miura Hidetaka Noma Toshihiro Mino Shinnosuke Azuma Thitiya Seesan Shuichi Makita Yoshiaki Yasuno Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment using synthesized multi-contrast polarization-sensitive optical coherence tomography Scientific Reports Polarization-sensitive optical coherence tomography Convolutional neural network Retinal pigment epithelium Melanin Age-related macular degeneration Pigment epithelial detachment |
| title | Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment using synthesized multi-contrast polarization-sensitive optical coherence tomography |
| title_full | Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment using synthesized multi-contrast polarization-sensitive optical coherence tomography |
| title_fullStr | Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment using synthesized multi-contrast polarization-sensitive optical coherence tomography |
| title_full_unstemmed | Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment using synthesized multi-contrast polarization-sensitive optical coherence tomography |
| title_short | Evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment using synthesized multi-contrast polarization-sensitive optical coherence tomography |
| title_sort | evaluation of retinal pigment epithelium changes in serous pigment epithelial detachment using synthesized multi contrast polarization sensitive optical coherence tomography |
| topic | Polarization-sensitive optical coherence tomography Convolutional neural network Retinal pigment epithelium Melanin Age-related macular degeneration Pigment epithelial detachment |
| url | https://doi.org/10.1038/s41598-025-09302-6 |
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