Review of electrophysiological models to study membrane potential changes in breast cancer cell transformation and tumor progression
The transformation of normal breast cells into cancerous cells is a complex process influenced by both genetic and microenvironmental factors. Recent studies highlight the significant role of membrane potential (Vm) alterations in this transformation. Cancer cells typically exhibit a depolarized res...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Physiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphys.2025.1536165/full |
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| author | Chitaranjan Mahapatra Arnaw Kishore Jineetkumar Gawad Ahmed Al-Emam Riad Azzam Kouzeiha Maher Ali Rusho |
| author_facet | Chitaranjan Mahapatra Arnaw Kishore Jineetkumar Gawad Ahmed Al-Emam Riad Azzam Kouzeiha Maher Ali Rusho |
| author_sort | Chitaranjan Mahapatra |
| collection | DOAJ |
| description | The transformation of normal breast cells into cancerous cells is a complex process influenced by both genetic and microenvironmental factors. Recent studies highlight the significant role of membrane potential (Vm) alterations in this transformation. Cancer cells typically exhibit a depolarized resting membrane potential (RMP) compared to normal cells, which correlates with increased cellular activity and more aggressive cancer behavior. These RMP and Vm changes are associated with altered ion channel activity, altered calcium dynamics, mitochondrial dysfunction, modified gap junction communication, and disrupted signaling pathways. Such fluctuations in RMP and Vm influence key processes in cancer progression, including cell proliferation, migration, and invasion. Notably, more aggressive subtypes of breast cancer cells display more frequent and pronounced Vm fluctuations. Understanding the electrical properties of cancer cells provides new insights into their behavior and offers potential therapeutic targets, such as ion channels and Vm regulation. This review synthesizes current research on how various factors modulate membrane potential and proposes an electrophysiological model of breast cancer cells based on experimental and clinical data from the literature. These findings may pave the way for novel pharmacological targets for clinicians, researchers, and pharmacologists in treating breast cancer. |
| format | Article |
| id | doaj-art-9f75daa7ed3f4b71be1c7d5322e1afb8 |
| institution | DOAJ |
| issn | 1664-042X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj-art-9f75daa7ed3f4b71be1c7d5322e1afb82025-08-20T03:15:30ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2025-03-011610.3389/fphys.2025.15361651536165Review of electrophysiological models to study membrane potential changes in breast cancer cell transformation and tumor progressionChitaranjan Mahapatra0Arnaw Kishore1Jineetkumar Gawad2Ahmed Al-Emam3Riad Azzam Kouzeiha4Maher Ali Rusho5Paris Saclay Institute of Neuroscience, Paris Saclay University, Saclay, FranceMicrobiology and Immunology, Xavier University School of Medicine, Aruba, NetherlandsDepartment of Pharmaceutical Chemistry, VIVA Institute of Pharmacy, Virar, IndiaDepartment of Pathology, College of Medicine, King Khalid University, Asir, Saudi ArabiaFaculty of Medical Sciences, Lebanese University, Hadath Campus, Beirut, LebanonDepartment of Biomedical Engineering, University of Colorado Boulder, Boulder, CO, United StatesThe transformation of normal breast cells into cancerous cells is a complex process influenced by both genetic and microenvironmental factors. Recent studies highlight the significant role of membrane potential (Vm) alterations in this transformation. Cancer cells typically exhibit a depolarized resting membrane potential (RMP) compared to normal cells, which correlates with increased cellular activity and more aggressive cancer behavior. These RMP and Vm changes are associated with altered ion channel activity, altered calcium dynamics, mitochondrial dysfunction, modified gap junction communication, and disrupted signaling pathways. Such fluctuations in RMP and Vm influence key processes in cancer progression, including cell proliferation, migration, and invasion. Notably, more aggressive subtypes of breast cancer cells display more frequent and pronounced Vm fluctuations. Understanding the electrical properties of cancer cells provides new insights into their behavior and offers potential therapeutic targets, such as ion channels and Vm regulation. This review synthesizes current research on how various factors modulate membrane potential and proposes an electrophysiological model of breast cancer cells based on experimental and clinical data from the literature. These findings may pave the way for novel pharmacological targets for clinicians, researchers, and pharmacologists in treating breast cancer.https://www.frontiersin.org/articles/10.3389/fphys.2025.1536165/fullbreast cancermembrane potentialion channelsgap junctioncalcium dynamicselectrophysiological model |
| spellingShingle | Chitaranjan Mahapatra Arnaw Kishore Jineetkumar Gawad Ahmed Al-Emam Riad Azzam Kouzeiha Maher Ali Rusho Review of electrophysiological models to study membrane potential changes in breast cancer cell transformation and tumor progression Frontiers in Physiology breast cancer membrane potential ion channels gap junction calcium dynamics electrophysiological model |
| title | Review of electrophysiological models to study membrane potential changes in breast cancer cell transformation and tumor progression |
| title_full | Review of electrophysiological models to study membrane potential changes in breast cancer cell transformation and tumor progression |
| title_fullStr | Review of electrophysiological models to study membrane potential changes in breast cancer cell transformation and tumor progression |
| title_full_unstemmed | Review of electrophysiological models to study membrane potential changes in breast cancer cell transformation and tumor progression |
| title_short | Review of electrophysiological models to study membrane potential changes in breast cancer cell transformation and tumor progression |
| title_sort | review of electrophysiological models to study membrane potential changes in breast cancer cell transformation and tumor progression |
| topic | breast cancer membrane potential ion channels gap junction calcium dynamics electrophysiological model |
| url | https://www.frontiersin.org/articles/10.3389/fphys.2025.1536165/full |
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