Oropharyngeal Manifestations in Patients with HIV from Northeastern Romania
<i>Backgrounds and objective</i>: Disorders in the stomatognathic system and otorhinolaryngologic manifestations are frequently observed in individuals living with HIV. Ear, neck, and throat (ENT) signs and symptoms often serve as critical markers of treatment failure, particularly in th...
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2025-05-01
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| author | Amelia Elena Surdu Isabela Ioana Loghin Victor Daniel Dorobăţ Vlad Hârtie Șerban Alin Rusu Ion Cecan Amelia Andreea Mihăescu Otilia Eva Carmen Mihaela Dorobăț |
| author_facet | Amelia Elena Surdu Isabela Ioana Loghin Victor Daniel Dorobăţ Vlad Hârtie Șerban Alin Rusu Ion Cecan Amelia Andreea Mihăescu Otilia Eva Carmen Mihaela Dorobăț |
| author_sort | Amelia Elena Surdu |
| collection | DOAJ |
| description | <i>Backgrounds and objective</i>: Disorders in the stomatognathic system and otorhinolaryngologic manifestations are frequently observed in individuals living with HIV. Ear, neck, and throat (ENT) signs and symptoms often serve as critical markers of treatment failure, particularly in the advanced stages of HIV infection. This article aims to evaluate and consolidate recent developments in the treatment and management of otorhinolaryngological manifestations in HIV-positive patients. <i>Materials and methods</i>: We carried out a retrospective clinical investigation of patients admitted with HIV/AIDS in the northeastern region of Romania, hospitalized in the “St. Parascheva” Clinical Hospital of Infectious Diseases in Iasi. We followed the viro-immunological status correlated with patients’ otolaryngology and dental symptomatology, aiming to emphasize the comorbidities of HIV/AIDS cases. The study period spanned from 1 January 2020 to 30 November 2024. <i>Results</i>: There were a total of 552 recorded cases of oropharyngeal manifestations in patients with HIV. They were more frequent in men (358 cases, 64.85%) than women (194 cases, 35.15%). The majority of cases were young adults, aged 30 to 39 years, comprising 255 patients (46.19%), and most cases (36.85%) had CD4+ T-lymphocyte values between 200 and 499 cells/μL. The most frequent diagnosis was oral candidiasis, recorded in 335 male and 174 female cases (509, 92.21% total). Other notable conditions included gingivitis/periodontitis, sinusitis/rhinosinusitis, mastoiditis, and dental abscesses, albeit at lower frequencies. Notably, antifungal therapy with fluconazole was the most frequently employed treatment, followed by aminopenicillins and fluoroquinolones. With respect to the antiretroviral treatment, 83.69% of cases were prescribed a single-pill regimen. <i>Conclusions</i>: The key to the management of HIV-positive patients is a multidisciplinary approach, including an ENT specialist and access to antiretroviral therapy. |
| format | Article |
| id | doaj-art-9f6de7309e194f9c9cd85806daa2f643 |
| institution | DOAJ |
| issn | 1010-660X 1648-9144 |
| language | English |
| publishDate | 2025-05-01 |
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| series | Medicina |
| spelling | doaj-art-9f6de7309e194f9c9cd85806daa2f6432025-08-20T03:14:41ZengMDPI AGMedicina1010-660X1648-91442025-05-0161585510.3390/medicina61050855Oropharyngeal Manifestations in Patients with HIV from Northeastern RomaniaAmelia Elena Surdu0Isabela Ioana Loghin1Victor Daniel Dorobăţ2Vlad Hârtie3Șerban Alin Rusu4Ion Cecan5Amelia Andreea Mihăescu6Otilia Eva7Carmen Mihaela Dorobăț8Department of Implantology, Removable Prostheses and Technology, Faculty of Dental Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Infectious Diseases, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, RomaniaDepartment of Intensive Care, University Hospital of Emergency, 050098 Bucharest, RomaniaDepartment of Intensive Care, Clinical Hospital of Emergency “Prof. Dr. Nicolae Oblu”, 700309 Iasi, RomaniaDepartment of Infectious Diseases, “St. Parascheva” Clinical Hospital of Infectious Diseases, 700116 Iasi, RomaniaDepartment of Infectious Diseases, “St. Parascheva” Clinical Hospital of Infectious Diseases, 700116 Iasi, RomaniaDepartment of Infectious Diseases, “St. Parascheva” Clinical Hospital of Infectious Diseases, 700116 Iasi, RomaniaDepartment of Infectious Diseases, “St. Parascheva” Clinical Hospital of Infectious Diseases, 700116 Iasi, RomaniaDepartment of Infectious Diseases, “St. Parascheva” Clinical Hospital of Infectious Diseases, 700116 Iasi, Romania<i>Backgrounds and objective</i>: Disorders in the stomatognathic system and otorhinolaryngologic manifestations are frequently observed in individuals living with HIV. Ear, neck, and throat (ENT) signs and symptoms often serve as critical markers of treatment failure, particularly in the advanced stages of HIV infection. This article aims to evaluate and consolidate recent developments in the treatment and management of otorhinolaryngological manifestations in HIV-positive patients. <i>Materials and methods</i>: We carried out a retrospective clinical investigation of patients admitted with HIV/AIDS in the northeastern region of Romania, hospitalized in the “St. Parascheva” Clinical Hospital of Infectious Diseases in Iasi. We followed the viro-immunological status correlated with patients’ otolaryngology and dental symptomatology, aiming to emphasize the comorbidities of HIV/AIDS cases. The study period spanned from 1 January 2020 to 30 November 2024. <i>Results</i>: There were a total of 552 recorded cases of oropharyngeal manifestations in patients with HIV. They were more frequent in men (358 cases, 64.85%) than women (194 cases, 35.15%). The majority of cases were young adults, aged 30 to 39 years, comprising 255 patients (46.19%), and most cases (36.85%) had CD4+ T-lymphocyte values between 200 and 499 cells/μL. The most frequent diagnosis was oral candidiasis, recorded in 335 male and 174 female cases (509, 92.21% total). Other notable conditions included gingivitis/periodontitis, sinusitis/rhinosinusitis, mastoiditis, and dental abscesses, albeit at lower frequencies. Notably, antifungal therapy with fluconazole was the most frequently employed treatment, followed by aminopenicillins and fluoroquinolones. With respect to the antiretroviral treatment, 83.69% of cases were prescribed a single-pill regimen. <i>Conclusions</i>: The key to the management of HIV-positive patients is a multidisciplinary approach, including an ENT specialist and access to antiretroviral therapy.https://www.mdpi.com/1648-9144/61/5/855stomatognathic systemENT manifestationsdental diagnosisHIV infectionoral disease |
| spellingShingle | Amelia Elena Surdu Isabela Ioana Loghin Victor Daniel Dorobăţ Vlad Hârtie Șerban Alin Rusu Ion Cecan Amelia Andreea Mihăescu Otilia Eva Carmen Mihaela Dorobăț Oropharyngeal Manifestations in Patients with HIV from Northeastern Romania Medicina stomatognathic system ENT manifestations dental diagnosis HIV infection oral disease |
| title | Oropharyngeal Manifestations in Patients with HIV from Northeastern Romania |
| title_full | Oropharyngeal Manifestations in Patients with HIV from Northeastern Romania |
| title_fullStr | Oropharyngeal Manifestations in Patients with HIV from Northeastern Romania |
| title_full_unstemmed | Oropharyngeal Manifestations in Patients with HIV from Northeastern Romania |
| title_short | Oropharyngeal Manifestations in Patients with HIV from Northeastern Romania |
| title_sort | oropharyngeal manifestations in patients with hiv from northeastern romania |
| topic | stomatognathic system ENT manifestations dental diagnosis HIV infection oral disease |
| url | https://www.mdpi.com/1648-9144/61/5/855 |
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