Brain network and energy imbalance in Parkinson’s disease: linking ATP reduction and α-synuclein pathology

Brain network and energy imbalance in Parkinson’s disease: linking ATP reduction and α-synuclein pathology

Parkinson’s disease (PD) involves the disruption of brain energy homeostasis. This encompasses broad-impact factors such as mitochondrial dysfunction, impaired glycolysis, and other metabolic disturbances, like disruptions in the pentose phosphate pathway and purine metabolism. Cortical hubs, which...

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Bibliographic Details
Main Authors: Hirohisa Watanabe, Sayuri Shima, Kazuya Kawabata, Yasuaki Mizutani, Akihiro Ueda, Mizuki Ito
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Molecular Neuroscience
Subjects:
ATP metabolism
cortical hubs
mitochondrial dysfunction
α-synuclein aggregation
energy imbalance
hypoxanthine
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2024.1507033/full
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