The effect of coenzyme Q10 on the state hemostasis in the blood of old animals in high-altitude conditions
In this study, the effect of oral administration of coenzyme Q10 on the blood coagulation system parameters in old rats under low- and high-altitude conditions was investigated. It was found that oral administration of coenzyme Q10 at a dose of 30 mg/kg body weight significantly reduced blood clotti...
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| Format: | Article |
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EDP Sciences
2025-01-01
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| Series: | E3S Web of Conferences |
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| Online Access: | https://www.e3s-conferences.org/articles/e3sconf/pdf/2025/08/e3sconf_eenviro2024_03003.pdf |
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| author | Gulbarchyn Alisherovna Asrankulova Zhyldyz Akmatovna Makhmudova Mahira Rysbaevna Mirzaeva Meerim Taalaibekovna Taalaibekova Zyinat Samidinovna Boronova Mairambu Bektemirovna Zhorobekova |
| author_facet | Gulbarchyn Alisherovna Asrankulova Zhyldyz Akmatovna Makhmudova Mahira Rysbaevna Mirzaeva Meerim Taalaibekovna Taalaibekova Zyinat Samidinovna Boronova Mairambu Bektemirovna Zhorobekova |
| author_sort | Gulbarchyn Alisherovna Asrankulova |
| collection | DOAJ |
| description | In this study, the effect of oral administration of coenzyme Q10 on the blood coagulation system parameters in old rats under low- and high-altitude conditions was investigated. It was found that oral administration of coenzyme Q10 at a dose of 30 mg/kg body weight significantly reduced blood clotting time and improved platelet aggregation parameters in old rats under low- and high-altitude conditions. In particular, a decrease in prothrombin time, prothrombin index, thrombin time and activated partial thromboplastin time, and a decrease in ADP concentration in old rats were observed. Consequently, the obtained results indicate the hypocoagulant effect of coenzyme Q10 in the hemostasis system in old rats. |
| format | Article |
| id | doaj-art-9f61700f78814d0796736965a206c1b5 |
| institution | Kabale University |
| issn | 2267-1242 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | EDP Sciences |
| record_format | Article |
| series | E3S Web of Conferences |
| spelling | doaj-art-9f61700f78814d0796736965a206c1b52025-02-05T10:49:33ZengEDP SciencesE3S Web of Conferences2267-12422025-01-016080300310.1051/e3sconf/202560803003e3sconf_eenviro2024_03003The effect of coenzyme Q10 on the state hemostasis in the blood of old animals in high-altitude conditionsGulbarchyn Alisherovna Asrankulova0Zhyldyz Akmatovna Makhmudova1Mahira Rysbaevna Mirzaeva2Meerim Taalaibekovna Taalaibekova3Zyinat Samidinovna Boronova4Mairambu Bektemirovna Zhorobekova5Department of Biochemistry with a course of general and bioorganic chemistry named after A.Dzh.Dzhumaliev, I.K. Akhunbaev Kyrgyz State Medical AcademyDepartment of Biochemistry with a course of general and bioorganic chemistry named after A.Dzh.Dzhumaliev, I.K. Akhunbaev Kyrgyz State Medical AcademyDepartment of Pharmaceutical Chemistry and Drug Technology, Osh State UniversityDepartment of Biochemistry with a course of general and bioorganic chemistry named after A.Dzh.Dzhumaliev, I.K. Akhunbaev Kyrgyz State Medical AcademyDepartment of Pharmaceutical Chemistry and Drug Technology, Osh State UniversityDepartment of Pharmaceutical Chemistry and Drug Technology, Osh State UniversityIn this study, the effect of oral administration of coenzyme Q10 on the blood coagulation system parameters in old rats under low- and high-altitude conditions was investigated. It was found that oral administration of coenzyme Q10 at a dose of 30 mg/kg body weight significantly reduced blood clotting time and improved platelet aggregation parameters in old rats under low- and high-altitude conditions. In particular, a decrease in prothrombin time, prothrombin index, thrombin time and activated partial thromboplastin time, and a decrease in ADP concentration in old rats were observed. Consequently, the obtained results indicate the hypocoagulant effect of coenzyme Q10 in the hemostasis system in old rats.https://www.e3s-conferences.org/articles/e3sconf/pdf/2025/08/e3sconf_eenviro2024_03003.pdfhigh altitudeold ratsoxidative stresshemostasiscoenzyme q10 |
| spellingShingle | Gulbarchyn Alisherovna Asrankulova Zhyldyz Akmatovna Makhmudova Mahira Rysbaevna Mirzaeva Meerim Taalaibekovna Taalaibekova Zyinat Samidinovna Boronova Mairambu Bektemirovna Zhorobekova The effect of coenzyme Q10 on the state hemostasis in the blood of old animals in high-altitude conditions E3S Web of Conferences high altitude old rats oxidative stress hemostasis coenzyme q10 |
| title | The effect of coenzyme Q10 on the state hemostasis in the blood of old animals in high-altitude conditions |
| title_full | The effect of coenzyme Q10 on the state hemostasis in the blood of old animals in high-altitude conditions |
| title_fullStr | The effect of coenzyme Q10 on the state hemostasis in the blood of old animals in high-altitude conditions |
| title_full_unstemmed | The effect of coenzyme Q10 on the state hemostasis in the blood of old animals in high-altitude conditions |
| title_short | The effect of coenzyme Q10 on the state hemostasis in the blood of old animals in high-altitude conditions |
| title_sort | effect of coenzyme q10 on the state hemostasis in the blood of old animals in high altitude conditions |
| topic | high altitude old rats oxidative stress hemostasis coenzyme q10 |
| url | https://www.e3s-conferences.org/articles/e3sconf/pdf/2025/08/e3sconf_eenviro2024_03003.pdf |
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