Effect of prepubertal caffeine consumption and recovery on adult erectile tissue functions in Wistar rats
The study examines the impact of caffeine consumption during prepubertal development and recovery on the contractile function of the adult corpus cavernosum in Wistar rats. Prepubertal male rats consumed distilled water (vehicle) and caffeine (5 mg/kg). A third group consumed caffeine and was allow...
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University of Ljubljana Press (Založba Univerze v Ljubljani)
2024-01-01
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| Series: | Acta Biologica Slovenica |
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| Online Access: | https://journals.uni-lj.si/abs/article/view/16294 |
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| author | Shakiru Salami Bashua Kassim Michael Allen Hussein Salahdeen Babatunde Murtala |
| author_facet | Shakiru Salami Bashua Kassim Michael Allen Hussein Salahdeen Babatunde Murtala |
| author_sort | Shakiru Salami |
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The study examines the impact of caffeine consumption during prepubertal development and recovery on the contractile function of the adult corpus cavernosum in Wistar rats. Prepubertal male rats consumed distilled water (vehicle) and caffeine (5 mg/kg). A third group consumed caffeine and was allowed a period of recovery. Cavernosa tissues were excised at adulthood, and their contractile functions in the presence of Ca2+, K+, indomethacin, glibenclamide, methyl blue, L-NAME, and sodium nitroprusside were assessed. K+-induced increase in contraction in the caffeine-treated group was similar to that in the recovery group. Ca2+ ions, however, increased contraction significantly in the caffeine group compared to the recovery group. Acetylcholine-mediated relaxation (%) was significantly higher in the recovery compared to the caffeine treated after incubation with indomethacin and methyl blue. Acetylcholine-mediated relaxation, however, was higher in caffeine as compared to the recovery group after incubation with glibenclamide and L-NAME. Relaxation in the presence of sodium nitroprusside was significantly reduced in recovery than in the caffeine-treated group. Prepubertal caffeine intake had an erectogenic effect on the cavernous tissues in the presence of glibenclamide, nifedipine, and L-NAME. Inhibitors of prostacyclin (indomethacin) and cGMP (methyl blue) militate caffeine-induced relaxation. Effects were reversed after recovery.
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| format | Article |
| id | doaj-art-9f612987f21f411784531eba98c1da61 |
| institution | Kabale University |
| issn | 1854-3073 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | University of Ljubljana Press (Založba Univerze v Ljubljani) |
| record_format | Article |
| series | Acta Biologica Slovenica |
| spelling | doaj-art-9f612987f21f411784531eba98c1da612025-01-16T08:26:39ZengUniversity of Ljubljana Press (Založba Univerze v Ljubljani)Acta Biologica Slovenica1854-30732024-01-0167110.14720/abs.67.1.16294Effect of prepubertal caffeine consumption and recovery on adult erectile tissue functions in Wistar ratsShakiru Salami0Bashua Kassim1Michael Allen2Hussein SalahdeenBabatunde MurtalaLagos state University College of Medicine, Ikeja Lagos stateDepartment of Physiology, Lagos state University college of Medicine, Ikeja Lagos state Department of Physiology, Lagos state University college of Medicine, Ikeja Lagos state The study examines the impact of caffeine consumption during prepubertal development and recovery on the contractile function of the adult corpus cavernosum in Wistar rats. Prepubertal male rats consumed distilled water (vehicle) and caffeine (5 mg/kg). A third group consumed caffeine and was allowed a period of recovery. Cavernosa tissues were excised at adulthood, and their contractile functions in the presence of Ca2+, K+, indomethacin, glibenclamide, methyl blue, L-NAME, and sodium nitroprusside were assessed. K+-induced increase in contraction in the caffeine-treated group was similar to that in the recovery group. Ca2+ ions, however, increased contraction significantly in the caffeine group compared to the recovery group. Acetylcholine-mediated relaxation (%) was significantly higher in the recovery compared to the caffeine treated after incubation with indomethacin and methyl blue. Acetylcholine-mediated relaxation, however, was higher in caffeine as compared to the recovery group after incubation with glibenclamide and L-NAME. Relaxation in the presence of sodium nitroprusside was significantly reduced in recovery than in the caffeine-treated group. Prepubertal caffeine intake had an erectogenic effect on the cavernous tissues in the presence of glibenclamide, nifedipine, and L-NAME. Inhibitors of prostacyclin (indomethacin) and cGMP (methyl blue) militate caffeine-induced relaxation. Effects were reversed after recovery. https://journals.uni-lj.si/abs/article/view/16294Prepubertal caffeine consumptionerectile tissue functionrecoverymethyl blueindomethacinglibenclamide |
| spellingShingle | Shakiru Salami Bashua Kassim Michael Allen Hussein Salahdeen Babatunde Murtala Effect of prepubertal caffeine consumption and recovery on adult erectile tissue functions in Wistar rats Acta Biologica Slovenica Prepubertal caffeine consumption erectile tissue function recovery methyl blue indomethacin glibenclamide |
| title | Effect of prepubertal caffeine consumption and recovery on adult erectile tissue functions in Wistar rats |
| title_full | Effect of prepubertal caffeine consumption and recovery on adult erectile tissue functions in Wistar rats |
| title_fullStr | Effect of prepubertal caffeine consumption and recovery on adult erectile tissue functions in Wistar rats |
| title_full_unstemmed | Effect of prepubertal caffeine consumption and recovery on adult erectile tissue functions in Wistar rats |
| title_short | Effect of prepubertal caffeine consumption and recovery on adult erectile tissue functions in Wistar rats |
| title_sort | effect of prepubertal caffeine consumption and recovery on adult erectile tissue functions in wistar rats |
| topic | Prepubertal caffeine consumption erectile tissue function recovery methyl blue indomethacin glibenclamide |
| url | https://journals.uni-lj.si/abs/article/view/16294 |
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