T Cells and Adoptive Immunotherapy: Recent Developments and Future Prospects in Gastrointestinal Oncology
Gastrointestinal oncology is one of the foremost causes of death: the gastric cancer accounts for 10.4% of cancer deaths worldwide, the pancreatic cancer for 6%, and finally, the colorectal cancer for 9% of all cancer-related deaths. For all these gastrointestinal cancers, surgical tumor resection r...
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2011/320571 |
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| author | Amedeo Amedei Elena Niccolai Mario M. D'Elios |
| author_facet | Amedeo Amedei Elena Niccolai Mario M. D'Elios |
| author_sort | Amedeo Amedei |
| collection | DOAJ |
| description | Gastrointestinal oncology is one of the foremost causes of death: the gastric cancer accounts for 10.4% of cancer deaths worldwide, the pancreatic cancer for 6%, and finally, the colorectal cancer for 9% of all cancer-related deaths. For all these gastrointestinal cancers, surgical tumor resection remains the primary curative treatment, but the overall 5-year survival rate remains poor, ranging between 20–25%; the addition of combined modality strategies (pre- or postoperative chemoradiotherapy or perioperative chemotherapy) results in 5-year survival rates of only 30–35%. Therefore, many investigators believe that the potential for making significant progress lies on understanding and exploiting the molecular biology of gastrointestinal tumors to investigate new therapeutic strategies such as specific immunotherapy. In this paper we will focus on recent knowledge concerning the role of T cells and the use of T adoptive immunotherapy in the treatment of gastrointestinal cancers. |
| format | Article |
| id | doaj-art-9f5e628efb91416d9aa61a066f729a86 |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-9f5e628efb91416d9aa61a066f729a862025-08-20T02:20:30ZengWileyClinical and Developmental Immunology1740-25221740-25302011-01-01201110.1155/2011/320571320571T Cells and Adoptive Immunotherapy: Recent Developments and Future Prospects in Gastrointestinal OncologyAmedeo Amedei0Elena Niccolai1Mario M. D'Elios2Department of Internal Medicine, University of Florence, Viale Morgagni 85, 50134 Florence, ItalyDepartment of Internal Medicine, University of Florence, Viale Morgagni 85, 50134 Florence, ItalyDepartment of Internal Medicine, University of Florence, Viale Morgagni 85, 50134 Florence, ItalyGastrointestinal oncology is one of the foremost causes of death: the gastric cancer accounts for 10.4% of cancer deaths worldwide, the pancreatic cancer for 6%, and finally, the colorectal cancer for 9% of all cancer-related deaths. For all these gastrointestinal cancers, surgical tumor resection remains the primary curative treatment, but the overall 5-year survival rate remains poor, ranging between 20–25%; the addition of combined modality strategies (pre- or postoperative chemoradiotherapy or perioperative chemotherapy) results in 5-year survival rates of only 30–35%. Therefore, many investigators believe that the potential for making significant progress lies on understanding and exploiting the molecular biology of gastrointestinal tumors to investigate new therapeutic strategies such as specific immunotherapy. In this paper we will focus on recent knowledge concerning the role of T cells and the use of T adoptive immunotherapy in the treatment of gastrointestinal cancers.http://dx.doi.org/10.1155/2011/320571 |
| spellingShingle | Amedeo Amedei Elena Niccolai Mario M. D'Elios T Cells and Adoptive Immunotherapy: Recent Developments and Future Prospects in Gastrointestinal Oncology Clinical and Developmental Immunology |
| title | T Cells and Adoptive Immunotherapy: Recent Developments and Future Prospects in Gastrointestinal Oncology |
| title_full | T Cells and Adoptive Immunotherapy: Recent Developments and Future Prospects in Gastrointestinal Oncology |
| title_fullStr | T Cells and Adoptive Immunotherapy: Recent Developments and Future Prospects in Gastrointestinal Oncology |
| title_full_unstemmed | T Cells and Adoptive Immunotherapy: Recent Developments and Future Prospects in Gastrointestinal Oncology |
| title_short | T Cells and Adoptive Immunotherapy: Recent Developments and Future Prospects in Gastrointestinal Oncology |
| title_sort | t cells and adoptive immunotherapy recent developments and future prospects in gastrointestinal oncology |
| url | http://dx.doi.org/10.1155/2011/320571 |
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