Melatonin: The potential avenues in dentistry [version 1; peer review: 2 approved, 1 approved with reservations]
Melatonin, the “sleep hormone,” shows significant promise in dentistry owing to its antioxidant, anti-inflammatory, and immunomodulatory properties. It is beneficial for treating periodontal disorders and aiding osseointegration of dental implants. Additionally, melatonin helps to manage dental anxi...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
F1000 Research Ltd
2025-01-01
|
| Series: | F1000Research |
| Subjects: | |
| Online Access: | https://f1000research.com/articles/14-77/v1 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849343429101748224 |
|---|---|
| author | DIYA KAMATH ARADHYA SINHA Dr. SANIDHYA S Deepa Kamath |
| author_facet | DIYA KAMATH ARADHYA SINHA Dr. SANIDHYA S Deepa Kamath |
| author_sort | DIYA KAMATH |
| collection | DOAJ |
| description | Melatonin, the “sleep hormone,” shows significant promise in dentistry owing to its antioxidant, anti-inflammatory, and immunomodulatory properties. It is beneficial for treating periodontal disorders and aiding osseointegration of dental implants. Additionally, melatonin helps to manage dental anxiety, offering an alternative to traditional sedatives. Periodontal disease is orchestrated by bacterial plaques along with an exaggerated immune-inflammatory host response. Treatment of periodontitis not only involves the removal of plaque, but also aims to minimize the cytokine load and control the reactive oxygen species burden in the tissues, which would re-establish a healthy periodontium and a balanced bone metabolism. Melatonin is known to exert beneficial effects, such as regulation of circadian rhythm, bone remodeling, and antimicrobial effects. Recent studies have demonstrated the successful use of melatonin as an adjunct to mechanical debridement for the treatment of periodontal disease. Its various uses include systemic administration of melatonin after one-stage full-mouth Non-Surgical Periodontal Therapy in healthy subjects as well as patients. This article provides a summary of the various clinical applications of melatonin, describing its mechanism of action, uses, and potential avenues for future research in dentistry. |
| format | Article |
| id | doaj-art-9f577803dbc1459a9b98b34c2da245e8 |
| institution | Kabale University |
| issn | 2046-1402 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj-art-9f577803dbc1459a9b98b34c2da245e82025-08-20T03:43:00ZengF1000 Research LtdF1000Research2046-14022025-01-011410.12688/f1000research.159942.1175736Melatonin: The potential avenues in dentistry [version 1; peer review: 2 approved, 1 approved with reservations]DIYA KAMATH0ARADHYA SINHA1Dr. SANIDHYA S2Deepa Kamath3https://orcid.org/0000-0002-8546-9590BDS, Manipal college of dental science, Manipal, IndiaDepartment of Periodontology, Manipal Academy of Higher Education, Manipal, Karnataka, 575001, IndiaDepartment of Periodontology, Manipal Academy of Higher Education, Manipal, Karnataka, 575001, IndiaDepartment of Periodontology, Manipal Academy of Higher Education, Manipal, Karnataka, 575001, IndiaMelatonin, the “sleep hormone,” shows significant promise in dentistry owing to its antioxidant, anti-inflammatory, and immunomodulatory properties. It is beneficial for treating periodontal disorders and aiding osseointegration of dental implants. Additionally, melatonin helps to manage dental anxiety, offering an alternative to traditional sedatives. Periodontal disease is orchestrated by bacterial plaques along with an exaggerated immune-inflammatory host response. Treatment of periodontitis not only involves the removal of plaque, but also aims to minimize the cytokine load and control the reactive oxygen species burden in the tissues, which would re-establish a healthy periodontium and a balanced bone metabolism. Melatonin is known to exert beneficial effects, such as regulation of circadian rhythm, bone remodeling, and antimicrobial effects. Recent studies have demonstrated the successful use of melatonin as an adjunct to mechanical debridement for the treatment of periodontal disease. Its various uses include systemic administration of melatonin after one-stage full-mouth Non-Surgical Periodontal Therapy in healthy subjects as well as patients. This article provides a summary of the various clinical applications of melatonin, describing its mechanism of action, uses, and potential avenues for future research in dentistry.https://f1000research.com/articles/14-77/v1periodontal disease melatonin melatonin for implant dentistry melatonin for bone regeneration osseointegrationeng |
| spellingShingle | DIYA KAMATH ARADHYA SINHA Dr. SANIDHYA S Deepa Kamath Melatonin: The potential avenues in dentistry [version 1; peer review: 2 approved, 1 approved with reservations] F1000Research periodontal disease melatonin melatonin for implant dentistry melatonin for bone regeneration osseointegration eng |
| title | Melatonin: The potential avenues in dentistry [version 1; peer review: 2 approved, 1 approved with reservations] |
| title_full | Melatonin: The potential avenues in dentistry [version 1; peer review: 2 approved, 1 approved with reservations] |
| title_fullStr | Melatonin: The potential avenues in dentistry [version 1; peer review: 2 approved, 1 approved with reservations] |
| title_full_unstemmed | Melatonin: The potential avenues in dentistry [version 1; peer review: 2 approved, 1 approved with reservations] |
| title_short | Melatonin: The potential avenues in dentistry [version 1; peer review: 2 approved, 1 approved with reservations] |
| title_sort | melatonin the potential avenues in dentistry version 1 peer review 2 approved 1 approved with reservations |
| topic | periodontal disease melatonin melatonin for implant dentistry melatonin for bone regeneration osseointegration eng |
| url | https://f1000research.com/articles/14-77/v1 |
| work_keys_str_mv | AT diyakamath melatoninthepotentialavenuesindentistryversion1peerreview2approved1approvedwithreservations AT aradhyasinha melatoninthepotentialavenuesindentistryversion1peerreview2approved1approvedwithreservations AT drsanidhyas melatoninthepotentialavenuesindentistryversion1peerreview2approved1approvedwithreservations AT deepakamath melatoninthepotentialavenuesindentistryversion1peerreview2approved1approvedwithreservations |