Dysregulation of Mitochondrial in Pulmonary Hypertension-Related Right Ventricular Remodeling: Pathophysiological Features and Targeting Drugs
Pulmonary hypertension (PH) is a life-threatening condition characterized by right ventricular (RV) remodeling, which is a major determinant of patient survival. The progression of right ventricular remodeling is significantly influenced by mitochondrial dysfunction, providing profound insights into...
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| Format: | Article |
| Language: | English |
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IMR Press
2025-03-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/26/3/10.31083/RCM25781 |
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| author | Yuehan Wang Yingzhuo Wang Weifang Zhang |
| author_facet | Yuehan Wang Yingzhuo Wang Weifang Zhang |
| author_sort | Yuehan Wang |
| collection | DOAJ |
| description | Pulmonary hypertension (PH) is a life-threatening condition characterized by right ventricular (RV) remodeling, which is a major determinant of patient survival. The progression of right ventricular remodeling is significantly influenced by mitochondrial dysfunction, providing profound insights into vascular health and cardiovascular risk. In this review, we discuss the molecular targets, pathophysiological characteristics, and potential mechanisms underlying mitochondrial dysfunction in PH, encompassing disturbances in mitochondrial dynamics, inflammation, and dysregulation of mitochondrial energy metabolism. Finally, we review the primary therapeutic targets currently utilized to address cardiac dysfunction resulting from mitochondrial damage. Hopefully, this might inspire novel approaches to the management of cardiovascular disorders. |
| format | Article |
| id | doaj-art-9f557e8b078c41e2b9d86f28b6a98673 |
| institution | DOAJ |
| issn | 1530-6550 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj-art-9f557e8b078c41e2b9d86f28b6a986732025-08-20T02:48:16ZengIMR PressReviews in Cardiovascular Medicine1530-65502025-03-012632578110.31083/RCM25781S1530-6550(24)01703-4Dysregulation of Mitochondrial in Pulmonary Hypertension-Related Right Ventricular Remodeling: Pathophysiological Features and Targeting DrugsYuehan Wang0Yingzhuo Wang1Weifang Zhang2Departments of Pharmacy, The Second Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaThe First Clinical Medical College, Nanchang University, 330036 Nanchang, Jiangxi, ChinaDepartments of Pharmacy, The Second Affiliated Hospital of Nanchang University, 330006 Nanchang, Jiangxi, ChinaPulmonary hypertension (PH) is a life-threatening condition characterized by right ventricular (RV) remodeling, which is a major determinant of patient survival. The progression of right ventricular remodeling is significantly influenced by mitochondrial dysfunction, providing profound insights into vascular health and cardiovascular risk. In this review, we discuss the molecular targets, pathophysiological characteristics, and potential mechanisms underlying mitochondrial dysfunction in PH, encompassing disturbances in mitochondrial dynamics, inflammation, and dysregulation of mitochondrial energy metabolism. Finally, we review the primary therapeutic targets currently utilized to address cardiac dysfunction resulting from mitochondrial damage. Hopefully, this might inspire novel approaches to the management of cardiovascular disorders.https://www.imrpress.com/journal/RCM/26/3/10.31083/RCM25781mitochondrial dysfunctionpulmonary hypertensionright ventricular remodelingros productiontherapeutic targets |
| spellingShingle | Yuehan Wang Yingzhuo Wang Weifang Zhang Dysregulation of Mitochondrial in Pulmonary Hypertension-Related Right Ventricular Remodeling: Pathophysiological Features and Targeting Drugs Reviews in Cardiovascular Medicine mitochondrial dysfunction pulmonary hypertension right ventricular remodeling ros production therapeutic targets |
| title | Dysregulation of Mitochondrial in Pulmonary Hypertension-Related Right Ventricular Remodeling: Pathophysiological Features and Targeting Drugs |
| title_full | Dysregulation of Mitochondrial in Pulmonary Hypertension-Related Right Ventricular Remodeling: Pathophysiological Features and Targeting Drugs |
| title_fullStr | Dysregulation of Mitochondrial in Pulmonary Hypertension-Related Right Ventricular Remodeling: Pathophysiological Features and Targeting Drugs |
| title_full_unstemmed | Dysregulation of Mitochondrial in Pulmonary Hypertension-Related Right Ventricular Remodeling: Pathophysiological Features and Targeting Drugs |
| title_short | Dysregulation of Mitochondrial in Pulmonary Hypertension-Related Right Ventricular Remodeling: Pathophysiological Features and Targeting Drugs |
| title_sort | dysregulation of mitochondrial in pulmonary hypertension related right ventricular remodeling pathophysiological features and targeting drugs |
| topic | mitochondrial dysfunction pulmonary hypertension right ventricular remodeling ros production therapeutic targets |
| url | https://www.imrpress.com/journal/RCM/26/3/10.31083/RCM25781 |
| work_keys_str_mv | AT yuehanwang dysregulationofmitochondrialinpulmonaryhypertensionrelatedrightventricularremodelingpathophysiologicalfeaturesandtargetingdrugs AT yingzhuowang dysregulationofmitochondrialinpulmonaryhypertensionrelatedrightventricularremodelingpathophysiologicalfeaturesandtargetingdrugs AT weifangzhang dysregulationofmitochondrialinpulmonaryhypertensionrelatedrightventricularremodelingpathophysiologicalfeaturesandtargetingdrugs |