Efficacy and safety in synchronous core-needle biopsy and cryoablation for highly suspicious malignant pulmonary nodule
Abstract Background Percutaneous computed tomography (CT)-guided biopsy and cryoablation are commonly used techniques for diagnosing and treating pulmonary malignant tumors. Performing these procedures simultaneously allows for tissue diagnosis while potentially offering therapeutic benefits. This s...
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BMC
2025-06-01
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| Series: | Cancer Imaging |
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| Online Access: | https://doi.org/10.1186/s40644-025-00901-0 |
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| author | Tongyin Zhang Qiaoyu Xu Yuwan Hu Haoyu Li Haoran Du Zhenguo Huang Sheng Xie Meng Yang Yanyan Xu Hongliang Sun |
| author_facet | Tongyin Zhang Qiaoyu Xu Yuwan Hu Haoyu Li Haoran Du Zhenguo Huang Sheng Xie Meng Yang Yanyan Xu Hongliang Sun |
| author_sort | Tongyin Zhang |
| collection | DOAJ |
| description | Abstract Background Percutaneous computed tomography (CT)-guided biopsy and cryoablation are commonly used techniques for diagnosing and treating pulmonary malignant tumors. Performing these procedures simultaneously allows for tissue diagnosis while potentially offering therapeutic benefits. This study aimed to evaluate whether the efficacy and safety of simultaneous percutaneous CT-guided biopsy and cryoablation in managing pulmonary tumors suspected of malignancy are comparable to those of sequential procedures. Methods This retrospective study involved 124 patients with 131 highly suspicious malignant pulmonary nodules. Patients either underwent synchronous percutaneous core-needle biopsy and cryoablation (Group A) or separately underwent these procedures (Group B) from December 2020 to May 2024. All procedures were performed under CT guidance using a percutaneous approach. We analyzed technical success rates, complications, diagnostic yield, and local tumor control. Results Technical success rates were 100% in both groups. The rate of pneumothorax was 42.1% (16/38) in Group A and 34.9% (30/86) in Group B. In Group A, hemoptysis and pleural effusion rates were 18.4% (7/38) and 23.7% (9/38), respectively, while in Group B, these rates were 16.3% (14/86) and 12.8% (11/86). These differences were not statistically significant. The diagnostic positive rate in Group A was 87.5%. The mean follow-up duration was 11.8 months (95% confidence interval [CI], 10.2–13.4), with local tumor control rates of 97% for Group A and 88% for Group B. The effectiveness rates of synchronous and separate procedures were similar. Conclusion Synchronous biopsy-ablation is an effective method for obtaining tumor pathology and local treatment of lung tumors simultaneously. It is a viable option for select patients where expedited diagnosis-therapy is clinically justified, particularly when molecular profiling is not immediately indicated. |
| format | Article |
| id | doaj-art-9f53ac303b0f4c82babf3d545bf2dbc9 |
| institution | DOAJ |
| issn | 1470-7330 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Cancer Imaging |
| spelling | doaj-art-9f53ac303b0f4c82babf3d545bf2dbc92025-08-20T03:22:54ZengBMCCancer Imaging1470-73302025-06-012511910.1186/s40644-025-00901-0Efficacy and safety in synchronous core-needle biopsy and cryoablation for highly suspicious malignant pulmonary noduleTongyin Zhang0Qiaoyu Xu1Yuwan Hu2Haoyu Li3Haoran Du4Zhenguo Huang5Sheng Xie6Meng Yang7Yanyan Xu8Hongliang Sun9Department of Radiology, China-Japan Friendship HospitalDepartment of Radiology, Beijing Chao-Yang Hospital, Capital Medical UniversityDepartment of Radiology, China-Japan Friendship HospitalDepartment of Radiology, China-Japan Friendship HospitalDepartment of Radiology, China-Japan Friendship HospitalDepartment of Radiology, China-Japan Friendship HospitalDepartment of Radiology, China-Japan Friendship HospitalNational Center for Respiratory Medicine, State Key Laboratory of Respiratory Health and Multimorbidity, National Clinical Research Center for Respiratory Diseases, Institute of Respiratory Medicine, Department of Pulmonary and Critical Care Medicine, Center of Respiratory Medicine, Chinese Academy of Medical Sciences, China-Japan Friendship HospitalDepartment of Radiology, China-Japan Friendship HospitalDepartment of Radiology, China-Japan Friendship HospitalAbstract Background Percutaneous computed tomography (CT)-guided biopsy and cryoablation are commonly used techniques for diagnosing and treating pulmonary malignant tumors. Performing these procedures simultaneously allows for tissue diagnosis while potentially offering therapeutic benefits. This study aimed to evaluate whether the efficacy and safety of simultaneous percutaneous CT-guided biopsy and cryoablation in managing pulmonary tumors suspected of malignancy are comparable to those of sequential procedures. Methods This retrospective study involved 124 patients with 131 highly suspicious malignant pulmonary nodules. Patients either underwent synchronous percutaneous core-needle biopsy and cryoablation (Group A) or separately underwent these procedures (Group B) from December 2020 to May 2024. All procedures were performed under CT guidance using a percutaneous approach. We analyzed technical success rates, complications, diagnostic yield, and local tumor control. Results Technical success rates were 100% in both groups. The rate of pneumothorax was 42.1% (16/38) in Group A and 34.9% (30/86) in Group B. In Group A, hemoptysis and pleural effusion rates were 18.4% (7/38) and 23.7% (9/38), respectively, while in Group B, these rates were 16.3% (14/86) and 12.8% (11/86). These differences were not statistically significant. The diagnostic positive rate in Group A was 87.5%. The mean follow-up duration was 11.8 months (95% confidence interval [CI], 10.2–13.4), with local tumor control rates of 97% for Group A and 88% for Group B. The effectiveness rates of synchronous and separate procedures were similar. Conclusion Synchronous biopsy-ablation is an effective method for obtaining tumor pathology and local treatment of lung tumors simultaneously. It is a viable option for select patients where expedited diagnosis-therapy is clinically justified, particularly when molecular profiling is not immediately indicated.https://doi.org/10.1186/s40644-025-00901-0Core needle biopsyCryoablationComputed tomographyMalignant pulmonary nodule |
| spellingShingle | Tongyin Zhang Qiaoyu Xu Yuwan Hu Haoyu Li Haoran Du Zhenguo Huang Sheng Xie Meng Yang Yanyan Xu Hongliang Sun Efficacy and safety in synchronous core-needle biopsy and cryoablation for highly suspicious malignant pulmonary nodule Cancer Imaging Core needle biopsy Cryoablation Computed tomography Malignant pulmonary nodule |
| title | Efficacy and safety in synchronous core-needle biopsy and cryoablation for highly suspicious malignant pulmonary nodule |
| title_full | Efficacy and safety in synchronous core-needle biopsy and cryoablation for highly suspicious malignant pulmonary nodule |
| title_fullStr | Efficacy and safety in synchronous core-needle biopsy and cryoablation for highly suspicious malignant pulmonary nodule |
| title_full_unstemmed | Efficacy and safety in synchronous core-needle biopsy and cryoablation for highly suspicious malignant pulmonary nodule |
| title_short | Efficacy and safety in synchronous core-needle biopsy and cryoablation for highly suspicious malignant pulmonary nodule |
| title_sort | efficacy and safety in synchronous core needle biopsy and cryoablation for highly suspicious malignant pulmonary nodule |
| topic | Core needle biopsy Cryoablation Computed tomography Malignant pulmonary nodule |
| url | https://doi.org/10.1186/s40644-025-00901-0 |
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