Long-Term Follow-Up, Association between CARD15/NOD2 Polymorphisms, and Clinical Disease Behavior in Crohn’s Disease Surgical Patients
Background. CARD15/NOD2 is the most significant genetic susceptibility in Crohn’s disease (CD) even though a relationship between the different polymorphisms and clinical phenotype has not been described yet. The study is aimed at analyzing, in a group of CD patients undergoing surgery, the relation...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/8854916 |
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| author | Francesco Giudici Tiziana Cavalli Cristina Luceri Edda Russo Daniela Zambonin Stefano Scaringi Ferdinando Ficari Marilena Fazi Amedeo Amedei Francesco Tonelli Cecilia Malentacchi |
| author_facet | Francesco Giudici Tiziana Cavalli Cristina Luceri Edda Russo Daniela Zambonin Stefano Scaringi Ferdinando Ficari Marilena Fazi Amedeo Amedei Francesco Tonelli Cecilia Malentacchi |
| author_sort | Francesco Giudici |
| collection | DOAJ |
| description | Background. CARD15/NOD2 is the most significant genetic susceptibility in Crohn’s disease (CD) even though a relationship between the different polymorphisms and clinical phenotype has not been described yet. The study is aimed at analyzing, in a group of CD patients undergoing surgery, the relationship between CARD15/NOD2 polymorphisms and the clinical CD behavior after a long-term follow-up, in order to identify potential clinical biomarkers of prognosis. Methods. 191 surgical CD patients were prospectively characterized both for the main single nucleotide polymorphisms of CARD15/NOD2 and for many other environmental risk factors connected with the severe disease form. After a mean follow-up of 7.3 years, the correlations between clinical features and CD natural history were analyzed. Results. CARD15/NOD2 polymorphisms were significantly associated with younger age at diagnosis compared to wild type cases (p<0.05). Moreover, patients carrying a 3020insC polymorphism presented a larger Δ between diagnosis and surgery (p=0.0344). Patients carrying an hz881 and a 3020insC exhibited, respectively, a lower rate of responsiveness to azathioprine (p=0.012), but no difference was found in biologic therapy. Finally, the risk of surgical recurrence was significantly associated, respectively, to age at diagnosis, to familial CD history, to diagnostic delay, to arthritis, and to the presence of perioperative complications. Conclusions. 3020insC CARD15 polymorphism is associated with an earlier CD onset, and age at CD diagnosis<27 years was confirmed to have a detrimental effect on its clinical course. In addition, the familiarity seems to be connected with a more aggressive postoperative course. Finally, for the first time, we have observed a lower rate of responsiveness to azathioprine in patients carrying an hz881 and a 3020insC. |
| format | Article |
| id | doaj-art-9f4acd5a3ba74e2883ca3e54184e4edf |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9f4acd5a3ba74e2883ca3e54184e4edf2025-02-03T06:07:16ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/88549168854916Long-Term Follow-Up, Association between CARD15/NOD2 Polymorphisms, and Clinical Disease Behavior in Crohn’s Disease Surgical PatientsFrancesco Giudici0Tiziana Cavalli1Cristina Luceri2Edda Russo3Daniela Zambonin4Stefano Scaringi5Ferdinando Ficari6Marilena Fazi7Amedeo Amedei8Francesco Tonelli9Cecilia Malentacchi10Department of Clinical and Experimental Medicine, Surgical Unit, University of Florence, ItalyDepartment of Clinical and Experimental Medicine, Surgical Unit, University of Florence, ItalyDepartment of Neuroscience, Psychology, Pharmacology and Child Health (NEUROFARBA), ItalyDepartment of Clinical and Experimental Medicine, Surgical Unit, University of Florence, ItalyDepartment of Clinical and Experimental Medicine, Surgical Unit, University of Florence, ItalyDepartment of Clinical and Experimental Medicine, Surgical Unit, University of Florence, ItalyDepartment of Clinical and Experimental Medicine, Surgical Unit, University of Florence, ItalyDepartment of Clinical and Experimental Medicine, Surgical Unit, University of Florence, ItalyDepartment of Clinical and Experimental Medicine, Surgical Unit, University of Florence, ItalyDepartment of Clinical and Experimental Medicine, Surgical Unit, University of Florence, ItalyDepartment of Biomedical Experimental and Clinical Sciences, “Mario Serio”, ItalyBackground. CARD15/NOD2 is the most significant genetic susceptibility in Crohn’s disease (CD) even though a relationship between the different polymorphisms and clinical phenotype has not been described yet. The study is aimed at analyzing, in a group of CD patients undergoing surgery, the relationship between CARD15/NOD2 polymorphisms and the clinical CD behavior after a long-term follow-up, in order to identify potential clinical biomarkers of prognosis. Methods. 191 surgical CD patients were prospectively characterized both for the main single nucleotide polymorphisms of CARD15/NOD2 and for many other environmental risk factors connected with the severe disease form. After a mean follow-up of 7.3 years, the correlations between clinical features and CD natural history were analyzed. Results. CARD15/NOD2 polymorphisms were significantly associated with younger age at diagnosis compared to wild type cases (p<0.05). Moreover, patients carrying a 3020insC polymorphism presented a larger Δ between diagnosis and surgery (p=0.0344). Patients carrying an hz881 and a 3020insC exhibited, respectively, a lower rate of responsiveness to azathioprine (p=0.012), but no difference was found in biologic therapy. Finally, the risk of surgical recurrence was significantly associated, respectively, to age at diagnosis, to familial CD history, to diagnostic delay, to arthritis, and to the presence of perioperative complications. Conclusions. 3020insC CARD15 polymorphism is associated with an earlier CD onset, and age at CD diagnosis<27 years was confirmed to have a detrimental effect on its clinical course. In addition, the familiarity seems to be connected with a more aggressive postoperative course. Finally, for the first time, we have observed a lower rate of responsiveness to azathioprine in patients carrying an hz881 and a 3020insC.http://dx.doi.org/10.1155/2021/8854916 |
| spellingShingle | Francesco Giudici Tiziana Cavalli Cristina Luceri Edda Russo Daniela Zambonin Stefano Scaringi Ferdinando Ficari Marilena Fazi Amedeo Amedei Francesco Tonelli Cecilia Malentacchi Long-Term Follow-Up, Association between CARD15/NOD2 Polymorphisms, and Clinical Disease Behavior in Crohn’s Disease Surgical Patients Mediators of Inflammation |
| title | Long-Term Follow-Up, Association between CARD15/NOD2 Polymorphisms, and Clinical Disease Behavior in Crohn’s Disease Surgical Patients |
| title_full | Long-Term Follow-Up, Association between CARD15/NOD2 Polymorphisms, and Clinical Disease Behavior in Crohn’s Disease Surgical Patients |
| title_fullStr | Long-Term Follow-Up, Association between CARD15/NOD2 Polymorphisms, and Clinical Disease Behavior in Crohn’s Disease Surgical Patients |
| title_full_unstemmed | Long-Term Follow-Up, Association between CARD15/NOD2 Polymorphisms, and Clinical Disease Behavior in Crohn’s Disease Surgical Patients |
| title_short | Long-Term Follow-Up, Association between CARD15/NOD2 Polymorphisms, and Clinical Disease Behavior in Crohn’s Disease Surgical Patients |
| title_sort | long term follow up association between card15 nod2 polymorphisms and clinical disease behavior in crohn s disease surgical patients |
| url | http://dx.doi.org/10.1155/2021/8854916 |
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