The evaluation of malignant astrocytoma score (MAS)
Background/Aim. At the moment there are few scoring systems for malignant astrocytoma but they are not widely accepted. The aim of this study was to evaluate malignant astrocytoma score (MAS) on a new group of patients with malignant astrocytoma, to compare MAS with other prognostic tools and to...
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| Format: | Article |
| Language: | English |
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Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade
2013-01-01
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| Series: | Vojnosanitetski Pregled |
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| Online Access: | http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501305452K.pdf |
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| _version_ | 1849698281103294464 |
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| author | Kojadinović Željko Vuleković Petar Jajić Đorđe Cigić Tomislav Papić Vladimir Đilvesi Đula Horvat Igor Karan Mladen |
| author_facet | Kojadinović Željko Vuleković Petar Jajić Đorđe Cigić Tomislav Papić Vladimir Đilvesi Đula Horvat Igor Karan Mladen |
| author_sort | Kojadinović Željko |
| collection | DOAJ |
| description | Background/Aim. At the moment there are few scoring systems for malignant astrocytoma but they are not widely accepted. The aim of this study was to evaluate malignant astrocytoma score (MAS) on a new group of patients with malignant astrocytoma, to compare MAS with other prognostic tools and to describe the use of MAS in everyday practice in neurooncology. Methods. The study was performed on 124 patients with supratentorial malignant astrocytoma grade III or IV. They were operated on and subsequently irradiated with 50-60 Gy. Results. The mean age of the patients was 57.3 years. The mean Karnofski performance status (KPS) of the functional inpairment was 54. The removal of the tumor > 90% was done in 59.7% of patients. The mean survival was 9.1 months, and 27.4% of patients had a 12-month survival. The area under receiver operating characteristic (ROC) curve (AUC) of the MAS for predicting 6-, 12- and 18-month survival was 0.754, 0.783 and 0.882, respectively. We compared the MAS with the two mostly cited scoring systems. The AUC for the same prediction for medical research council (MRC) was 0.601, 0.693, 0.772 respectively. For the Radiation Therapy Oncology Group (RTOG) the AUC was 0.732, 0.765, 0.827, respectively. Conclusion. MAS represents a useful scoring system for determining illness severity and prognosis in patients with malignant supratentorial astrocytoma. It can be helpful in comparing single patients or groups of patients, as well as results of different treatments and in controlling the quality of hospital treatment and so on. |
| format | Article |
| id | doaj-art-9f4a7a81f2944e009ff6eaa7c364e7c3 |
| institution | DOAJ |
| issn | 0042-8450 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Ministry of Defence of the Republic of Serbia, University of Defence, Belgrade |
| record_format | Article |
| series | Vojnosanitetski Pregled |
| spelling | doaj-art-9f4a7a81f2944e009ff6eaa7c364e7c32025-08-20T03:18:56ZengMinistry of Defence of the Republic of Serbia, University of Defence, BelgradeVojnosanitetski Pregled0042-84502013-01-0170545245610.2298/VSP1305452KThe evaluation of malignant astrocytoma score (MAS)Kojadinović ŽeljkoVuleković PetarJajić ĐorđeCigić TomislavPapić VladimirĐilvesi ĐulaHorvat IgorKaran MladenBackground/Aim. At the moment there are few scoring systems for malignant astrocytoma but they are not widely accepted. The aim of this study was to evaluate malignant astrocytoma score (MAS) on a new group of patients with malignant astrocytoma, to compare MAS with other prognostic tools and to describe the use of MAS in everyday practice in neurooncology. Methods. The study was performed on 124 patients with supratentorial malignant astrocytoma grade III or IV. They were operated on and subsequently irradiated with 50-60 Gy. Results. The mean age of the patients was 57.3 years. The mean Karnofski performance status (KPS) of the functional inpairment was 54. The removal of the tumor > 90% was done in 59.7% of patients. The mean survival was 9.1 months, and 27.4% of patients had a 12-month survival. The area under receiver operating characteristic (ROC) curve (AUC) of the MAS for predicting 6-, 12- and 18-month survival was 0.754, 0.783 and 0.882, respectively. We compared the MAS with the two mostly cited scoring systems. The AUC for the same prediction for medical research council (MRC) was 0.601, 0.693, 0.772 respectively. For the Radiation Therapy Oncology Group (RTOG) the AUC was 0.732, 0.765, 0.827, respectively. Conclusion. MAS represents a useful scoring system for determining illness severity and prognosis in patients with malignant supratentorial astrocytoma. It can be helpful in comparing single patients or groups of patients, as well as results of different treatments and in controlling the quality of hospital treatment and so on.http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501305452K.pdfastrocytomaclassificationneurosurgeryradiotherapyprognosis |
| spellingShingle | Kojadinović Željko Vuleković Petar Jajić Đorđe Cigić Tomislav Papić Vladimir Đilvesi Đula Horvat Igor Karan Mladen The evaluation of malignant astrocytoma score (MAS) Vojnosanitetski Pregled astrocytoma classification neurosurgery radiotherapy prognosis |
| title | The evaluation of malignant astrocytoma score (MAS) |
| title_full | The evaluation of malignant astrocytoma score (MAS) |
| title_fullStr | The evaluation of malignant astrocytoma score (MAS) |
| title_full_unstemmed | The evaluation of malignant astrocytoma score (MAS) |
| title_short | The evaluation of malignant astrocytoma score (MAS) |
| title_sort | evaluation of malignant astrocytoma score mas |
| topic | astrocytoma classification neurosurgery radiotherapy prognosis |
| url | http://www.doiserbia.nb.rs/img/doi/0042-8450/2013/0042-84501305452K.pdf |
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