RETRACTED: MicroRNA‐320a inhibits invasion and metastasis in osteosarcoma by targeting cytoplasmic polyadenylation element‐binding protein 1
Abstract Osteosarcoma is a primary malignant bone tumor, which affects children, adolescents, and young adults commonly. MicroRNAs (miRNAs) have been proved to be dysregulated in different cancers, including osteosarcoma. Although miR‐320a has been implicated in many types of malignancies, little is...
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| Format: | Article |
| Language: | English |
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Wiley
2020-04-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.2919 |
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| author | Yanlong Wang Jiyu Yang Pangtao Chen Yu Song Weizheng An Haoran Zhang Butegeleqi Butegeleqi Jinglong Yan |
| author_facet | Yanlong Wang Jiyu Yang Pangtao Chen Yu Song Weizheng An Haoran Zhang Butegeleqi Butegeleqi Jinglong Yan |
| author_sort | Yanlong Wang |
| collection | DOAJ |
| description | Abstract Osteosarcoma is a primary malignant bone tumor, which affects children, adolescents, and young adults commonly. MicroRNAs (miRNAs) have been proved to be dysregulated in different cancers, including osteosarcoma. Although miR‐320a has been implicated in many types of malignancies, little is known about the role of miR‐320a in osteosarcoma. In this study, we show that the overexpression of miR‐320a or knockdown of cytoplasmic polyadenylation element‐binding protein 1 (CPEB1) inhibited osteosarcoma cell migration and invasion. miR‐320a downregulates CPEB1 expression by directly targeting the CPEB1 3′‐UTR. Furthermore, CPEB1 reintroduction reversed the antiproliferation, antimigration, and antiinvasion roles of miR‐320a, indicating that miR‐320a might function as a tumor suppressor in osteosarcoma through CPEB1. In conclusion, our study demonstrates that miR‐320a plays a critical role in osteosarcoma progression and may provide a potential therapeutic target for osteosarcoma. |
| format | Article |
| id | doaj-art-9f4831b298a444478a090e38b977f4e2 |
| institution | Kabale University |
| issn | 2045-7634 |
| language | English |
| publishDate | 2020-04-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-9f4831b298a444478a090e38b977f4e22025-08-20T03:46:54ZengWileyCancer Medicine2045-76342020-04-01982833284510.1002/cam4.2919RETRACTED: MicroRNA‐320a inhibits invasion and metastasis in osteosarcoma by targeting cytoplasmic polyadenylation element‐binding protein 1Yanlong Wang0Jiyu Yang1Pangtao Chen2Yu Song3Weizheng An4Haoran Zhang5Butegeleqi Butegeleqi6Jinglong Yan7Departments of Orthopedic Surgery The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang P.R. ChinaDepartments of Orthopedic Surgery The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang P.R. ChinaDepartments of Orthopedic Surgery The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang P.R. ChinaDepartments of Orthopedic Surgery The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang P.R. ChinaDepartments of Orthopedic Surgery The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang P.R. ChinaDepartments of Orthopedic Surgery The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang P.R. ChinaDepartments of Orthopedic Surgery The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang P.R. ChinaDepartments of Orthopedic Surgery The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang P.R. ChinaAbstract Osteosarcoma is a primary malignant bone tumor, which affects children, adolescents, and young adults commonly. MicroRNAs (miRNAs) have been proved to be dysregulated in different cancers, including osteosarcoma. Although miR‐320a has been implicated in many types of malignancies, little is known about the role of miR‐320a in osteosarcoma. In this study, we show that the overexpression of miR‐320a or knockdown of cytoplasmic polyadenylation element‐binding protein 1 (CPEB1) inhibited osteosarcoma cell migration and invasion. miR‐320a downregulates CPEB1 expression by directly targeting the CPEB1 3′‐UTR. Furthermore, CPEB1 reintroduction reversed the antiproliferation, antimigration, and antiinvasion roles of miR‐320a, indicating that miR‐320a might function as a tumor suppressor in osteosarcoma through CPEB1. In conclusion, our study demonstrates that miR‐320a plays a critical role in osteosarcoma progression and may provide a potential therapeutic target for osteosarcoma.https://doi.org/10.1002/cam4.2919cytoplasmic polyadenylation element‐binding protein 1microRNAsmiR‐320aosteosarcoma |
| spellingShingle | Yanlong Wang Jiyu Yang Pangtao Chen Yu Song Weizheng An Haoran Zhang Butegeleqi Butegeleqi Jinglong Yan RETRACTED: MicroRNA‐320a inhibits invasion and metastasis in osteosarcoma by targeting cytoplasmic polyadenylation element‐binding protein 1 Cancer Medicine cytoplasmic polyadenylation element‐binding protein 1 microRNAs miR‐320a osteosarcoma |
| title | RETRACTED: MicroRNA‐320a inhibits invasion and metastasis in osteosarcoma by targeting cytoplasmic polyadenylation element‐binding protein 1 |
| title_full | RETRACTED: MicroRNA‐320a inhibits invasion and metastasis in osteosarcoma by targeting cytoplasmic polyadenylation element‐binding protein 1 |
| title_fullStr | RETRACTED: MicroRNA‐320a inhibits invasion and metastasis in osteosarcoma by targeting cytoplasmic polyadenylation element‐binding protein 1 |
| title_full_unstemmed | RETRACTED: MicroRNA‐320a inhibits invasion and metastasis in osteosarcoma by targeting cytoplasmic polyadenylation element‐binding protein 1 |
| title_short | RETRACTED: MicroRNA‐320a inhibits invasion and metastasis in osteosarcoma by targeting cytoplasmic polyadenylation element‐binding protein 1 |
| title_sort | retracted microrna 320a inhibits invasion and metastasis in osteosarcoma by targeting cytoplasmic polyadenylation element binding protein 1 |
| topic | cytoplasmic polyadenylation element‐binding protein 1 microRNAs miR‐320a osteosarcoma |
| url | https://doi.org/10.1002/cam4.2919 |
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