Treatment of Immunocompromised, Critically Ill Patients with Influenza A H1N1 Infection with a Combination of Oseltamivir, Amantadine, and Zanamivir
Immunocompromised patients are at increased risk of complications of influenza virus infection. We report on two critically ill patients on immunosuppressive medication with influenza pneumonia. In both patients, oseltamivir monotherapy did not result in clearance of the virus after 18 and five days...
Saved in:
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2015/504975 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832555429902680064 |
|---|---|
| author | Wouter J. Meijer Wiete Kromdijk Marcel P. H. van den Broek Pieter-Jan A. Haas Monique C. Minnema Charles A. Boucher Dylan W. de Lange Annemarie M. J. Wensing |
| author_facet | Wouter J. Meijer Wiete Kromdijk Marcel P. H. van den Broek Pieter-Jan A. Haas Monique C. Minnema Charles A. Boucher Dylan W. de Lange Annemarie M. J. Wensing |
| author_sort | Wouter J. Meijer |
| collection | DOAJ |
| description | Immunocompromised patients are at increased risk of complications of influenza virus infection. We report on two critically ill patients on immunosuppressive medication with influenza pneumonia. In both patients, oseltamivir monotherapy did not result in clearance of the virus after 18 and five days, respectively. After adding zanamivir and amantadine to the treatment, PCRs on pharyngeal and/or plasma specimens turned negative in both patients after four and three days, respectively. We suggest, that in critically ill patients with influenza A H1N1 infection, treatment efficacy should be monitored closely and treatment with a combination of antiviral drugs should be considered. |
| format | Article |
| id | doaj-art-9f4305ebb9e14aa6ab240fdc3f9ef021 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-9f4305ebb9e14aa6ab240fdc3f9ef0212025-02-03T05:48:19ZengWileyCase Reports in Infectious Diseases2090-66252090-66332015-01-01201510.1155/2015/504975504975Treatment of Immunocompromised, Critically Ill Patients with Influenza A H1N1 Infection with a Combination of Oseltamivir, Amantadine, and ZanamivirWouter J. Meijer0Wiete Kromdijk1Marcel P. H. van den Broek2Pieter-Jan A. Haas3Monique C. Minnema4Charles A. Boucher5Dylan W. de Lange6Annemarie M. J. Wensing7Wilhelmina Children’s Hospital, University Medical Center Utrecht, Lundlaan 6, P.O. Box 85090, Utrecht, NetherlandsDepartment of Pharmacy & Pharmacology, Slotervaart Hospital, 1066 EC Amsterdam, NetherlandsDepartment of Clinical Pharmacy, University Medical Center Utrecht, 3584 CX Utrecht, NetherlandsDepartment of Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, NetherlandsDepartment of Hematology, University Medical Center Utrecht, 3584 CX Utrecht, NetherlandsDepartment of Virology, Erasmus Medical Center, 3015 CE Rotterdam, NetherlandsDepartment of Intensive Care, University Medical Center Utrecht, 3584 CX Utrecht, NetherlandsDepartment of Virology, Medical Microbiology, University Medical Center Utrecht, 3584 CX Utrecht, NetherlandsImmunocompromised patients are at increased risk of complications of influenza virus infection. We report on two critically ill patients on immunosuppressive medication with influenza pneumonia. In both patients, oseltamivir monotherapy did not result in clearance of the virus after 18 and five days, respectively. After adding zanamivir and amantadine to the treatment, PCRs on pharyngeal and/or plasma specimens turned negative in both patients after four and three days, respectively. We suggest, that in critically ill patients with influenza A H1N1 infection, treatment efficacy should be monitored closely and treatment with a combination of antiviral drugs should be considered.http://dx.doi.org/10.1155/2015/504975 |
| spellingShingle | Wouter J. Meijer Wiete Kromdijk Marcel P. H. van den Broek Pieter-Jan A. Haas Monique C. Minnema Charles A. Boucher Dylan W. de Lange Annemarie M. J. Wensing Treatment of Immunocompromised, Critically Ill Patients with Influenza A H1N1 Infection with a Combination of Oseltamivir, Amantadine, and Zanamivir Case Reports in Infectious Diseases |
| title | Treatment of Immunocompromised, Critically Ill Patients with Influenza A H1N1 Infection with a Combination of Oseltamivir, Amantadine, and Zanamivir |
| title_full | Treatment of Immunocompromised, Critically Ill Patients with Influenza A H1N1 Infection with a Combination of Oseltamivir, Amantadine, and Zanamivir |
| title_fullStr | Treatment of Immunocompromised, Critically Ill Patients with Influenza A H1N1 Infection with a Combination of Oseltamivir, Amantadine, and Zanamivir |
| title_full_unstemmed | Treatment of Immunocompromised, Critically Ill Patients with Influenza A H1N1 Infection with a Combination of Oseltamivir, Amantadine, and Zanamivir |
| title_short | Treatment of Immunocompromised, Critically Ill Patients with Influenza A H1N1 Infection with a Combination of Oseltamivir, Amantadine, and Zanamivir |
| title_sort | treatment of immunocompromised critically ill patients with influenza a h1n1 infection with a combination of oseltamivir amantadine and zanamivir |
| url | http://dx.doi.org/10.1155/2015/504975 |
| work_keys_str_mv | AT wouterjmeijer treatmentofimmunocompromisedcriticallyillpatientswithinfluenzaah1n1infectionwithacombinationofoseltamiviramantadineandzanamivir AT wietekromdijk treatmentofimmunocompromisedcriticallyillpatientswithinfluenzaah1n1infectionwithacombinationofoseltamiviramantadineandzanamivir AT marcelphvandenbroek treatmentofimmunocompromisedcriticallyillpatientswithinfluenzaah1n1infectionwithacombinationofoseltamiviramantadineandzanamivir AT pieterjanahaas treatmentofimmunocompromisedcriticallyillpatientswithinfluenzaah1n1infectionwithacombinationofoseltamiviramantadineandzanamivir AT moniquecminnema treatmentofimmunocompromisedcriticallyillpatientswithinfluenzaah1n1infectionwithacombinationofoseltamiviramantadineandzanamivir AT charlesaboucher treatmentofimmunocompromisedcriticallyillpatientswithinfluenzaah1n1infectionwithacombinationofoseltamiviramantadineandzanamivir AT dylanwdelange treatmentofimmunocompromisedcriticallyillpatientswithinfluenzaah1n1infectionwithacombinationofoseltamiviramantadineandzanamivir AT annemariemjwensing treatmentofimmunocompromisedcriticallyillpatientswithinfluenzaah1n1infectionwithacombinationofoseltamiviramantadineandzanamivir |