Clinical Characteristics and Outcomes in Heart Failure Patients with Implantable Pulmonary Artery Pressure Monitors: A Single Centre Irish Experience
<b>Background:</b> Hospitalisation for acute decompensated heart failure (HF) portends a poor prognosis. Fluid retention manifesting in dyspnoea and oedema are important clinical features of decompensated heart failure and drive hospital admissions. Intracardiac and pulmonary artery pres...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
|
| Series: | Journal of Cardiovascular Development and Disease |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2308-3425/12/1/25 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832588291950510080 |
|---|---|
| author | Niall Leahy Cillian O’Brien Sara Essa Alsubai Eileen Coen Darragh Murphy Faisal Sharif |
| author_facet | Niall Leahy Cillian O’Brien Sara Essa Alsubai Eileen Coen Darragh Murphy Faisal Sharif |
| author_sort | Niall Leahy |
| collection | DOAJ |
| description | <b>Background:</b> Hospitalisation for acute decompensated heart failure (HF) portends a poor prognosis. Fluid retention manifesting in dyspnoea and oedema are important clinical features of decompensated heart failure and drive hospital admissions. Intracardiac and pulmonary artery pressure (PAP) monitoring can help predict heart failure decompensation, as changes in these haemodynamics occur before clinical congestion manifests. <b>Methods:</b> A retrospective single centre analysis of patients who underwent insertion of the Cordella™ PA Sensor System (Endotronix, Inc., Chicago, IL, USA) in University Hospital Galway, Ireland, as part of three separate clinical trials—SIRONA 1, SIRONA 2, PROACTIVE HF, was performed. The primary clinical outcome assessed was the difference between HF hospitalisation pre- and post-sensor implantation. <b>Results:</b> In total, there were 33 patients with symptomatic HF who underwent device insertion between 2018 and 2023. All patients had NYHA class 3 heart failure, and 48.5% (<i>n</i> = 16) of patients had HF with reduced ejection fraction. Only one device-related complication was noted, and no pressure sensor failures occurred. In total, there were 26 admissions for HF decompensation 1-year pre-device insertion and only three admissions post-insertion. The difference in the mean number of HF hospitalisations per patient pre- and post-device insertion was 0.70 (<i>p</i> < 0.0001). The difference in mean NYHA class score pre- and post-insertion was 1.0 (<i>p</i> < 0.001). <b>Conclusions:</b> Data from this single-centre cohort study have shown that the insertion of the Cordella™ PA Sensor System in symptomatic HF patients was safe and resulted in statistically significant improvements in HF hospitalisations and NYHA class. |
| format | Article |
| id | doaj-art-9f3e19d78c914e4bac54146f0445710a |
| institution | Kabale University |
| issn | 2308-3425 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj-art-9f3e19d78c914e4bac54146f0445710a2025-01-24T13:36:02ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252025-01-011212510.3390/jcdd12010025Clinical Characteristics and Outcomes in Heart Failure Patients with Implantable Pulmonary Artery Pressure Monitors: A Single Centre Irish ExperienceNiall Leahy0Cillian O’Brien1Sara Essa Alsubai2Eileen Coen3Darragh Murphy4Faisal Sharif5Department of Cardiology, University Hospital Galway, Saolta University Healthcare Group, Newcastle Road, H91YR71 Galway, IrelandDepartment of Cardiology, University Hospital Galway, Saolta University Healthcare Group, Newcastle Road, H91YR71 Galway, IrelandDepartment of Medicine, University of Galway, University Road, H91TK33 Galway, IrelandDepartment of Medicine, University of Galway, University Road, H91TK33 Galway, IrelandDepartment of Medicine, University of Galway, University Road, H91TK33 Galway, IrelandDepartment of Cardiology, University Hospital Galway, Saolta University Healthcare Group, Newcastle Road, H91YR71 Galway, Ireland<b>Background:</b> Hospitalisation for acute decompensated heart failure (HF) portends a poor prognosis. Fluid retention manifesting in dyspnoea and oedema are important clinical features of decompensated heart failure and drive hospital admissions. Intracardiac and pulmonary artery pressure (PAP) monitoring can help predict heart failure decompensation, as changes in these haemodynamics occur before clinical congestion manifests. <b>Methods:</b> A retrospective single centre analysis of patients who underwent insertion of the Cordella™ PA Sensor System (Endotronix, Inc., Chicago, IL, USA) in University Hospital Galway, Ireland, as part of three separate clinical trials—SIRONA 1, SIRONA 2, PROACTIVE HF, was performed. The primary clinical outcome assessed was the difference between HF hospitalisation pre- and post-sensor implantation. <b>Results:</b> In total, there were 33 patients with symptomatic HF who underwent device insertion between 2018 and 2023. All patients had NYHA class 3 heart failure, and 48.5% (<i>n</i> = 16) of patients had HF with reduced ejection fraction. Only one device-related complication was noted, and no pressure sensor failures occurred. In total, there were 26 admissions for HF decompensation 1-year pre-device insertion and only three admissions post-insertion. The difference in the mean number of HF hospitalisations per patient pre- and post-device insertion was 0.70 (<i>p</i> < 0.0001). The difference in mean NYHA class score pre- and post-insertion was 1.0 (<i>p</i> < 0.001). <b>Conclusions:</b> Data from this single-centre cohort study have shown that the insertion of the Cordella™ PA Sensor System in symptomatic HF patients was safe and resulted in statistically significant improvements in HF hospitalisations and NYHA class.https://www.mdpi.com/2308-3425/12/1/25heart failurepulmonary artery pressureremote monitoringdevices |
| spellingShingle | Niall Leahy Cillian O’Brien Sara Essa Alsubai Eileen Coen Darragh Murphy Faisal Sharif Clinical Characteristics and Outcomes in Heart Failure Patients with Implantable Pulmonary Artery Pressure Monitors: A Single Centre Irish Experience Journal of Cardiovascular Development and Disease heart failure pulmonary artery pressure remote monitoring devices |
| title | Clinical Characteristics and Outcomes in Heart Failure Patients with Implantable Pulmonary Artery Pressure Monitors: A Single Centre Irish Experience |
| title_full | Clinical Characteristics and Outcomes in Heart Failure Patients with Implantable Pulmonary Artery Pressure Monitors: A Single Centre Irish Experience |
| title_fullStr | Clinical Characteristics and Outcomes in Heart Failure Patients with Implantable Pulmonary Artery Pressure Monitors: A Single Centre Irish Experience |
| title_full_unstemmed | Clinical Characteristics and Outcomes in Heart Failure Patients with Implantable Pulmonary Artery Pressure Monitors: A Single Centre Irish Experience |
| title_short | Clinical Characteristics and Outcomes in Heart Failure Patients with Implantable Pulmonary Artery Pressure Monitors: A Single Centre Irish Experience |
| title_sort | clinical characteristics and outcomes in heart failure patients with implantable pulmonary artery pressure monitors a single centre irish experience |
| topic | heart failure pulmonary artery pressure remote monitoring devices |
| url | https://www.mdpi.com/2308-3425/12/1/25 |
| work_keys_str_mv | AT niallleahy clinicalcharacteristicsandoutcomesinheartfailurepatientswithimplantablepulmonaryarterypressuremonitorsasinglecentreirishexperience AT cillianobrien clinicalcharacteristicsandoutcomesinheartfailurepatientswithimplantablepulmonaryarterypressuremonitorsasinglecentreirishexperience AT saraessaalsubai clinicalcharacteristicsandoutcomesinheartfailurepatientswithimplantablepulmonaryarterypressuremonitorsasinglecentreirishexperience AT eileencoen clinicalcharacteristicsandoutcomesinheartfailurepatientswithimplantablepulmonaryarterypressuremonitorsasinglecentreirishexperience AT darraghmurphy clinicalcharacteristicsandoutcomesinheartfailurepatientswithimplantablepulmonaryarterypressuremonitorsasinglecentreirishexperience AT faisalsharif clinicalcharacteristicsandoutcomesinheartfailurepatientswithimplantablepulmonaryarterypressuremonitorsasinglecentreirishexperience |