Neurological, Radiological, Visual, and Auditory Findings in Children with Intrauterine Exposure to the Zika Virus

This study aims to describe neurological, visual, and auditory findings in children whose mothers had confirmed Zika virus (ZIKV) infection during pregnancy, with most of these children not presenting congenital microcephaly; Methods: an observational, longitudinal, and prospective study was conduct...

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Main Authors: Marlos Melo Martins, Andréa Bittencourt Guastavino, Maria Clara de Magalhães-Barbosa, Maria Helena de Magalhães-Barbosa, Cristiane Fregonesi Dutra Garcia, Bárbara Karine Gonet Amaral, Annamaria Ciminelli Barbosa, Halina Cidrini Ferreira, Jaqueline Rodrigues Robaina, Mariana Barros Genuino de Oliveira, Fernanda Freire Tovar-Moll, Roberto de Andrade Medronho, Antonio José Ledo Alves da Cunha, Joffre Amim, Arnaldo Prata-Barbosa
Format: Article
Language:English
Published: MDPI AG 2025-02-01
Series:Viruses
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Online Access:https://www.mdpi.com/1999-4915/17/2/238
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author Marlos Melo Martins
Andréa Bittencourt Guastavino
Maria Clara de Magalhães-Barbosa
Maria Helena de Magalhães-Barbosa
Cristiane Fregonesi Dutra Garcia
Bárbara Karine Gonet Amaral
Annamaria Ciminelli Barbosa
Halina Cidrini Ferreira
Jaqueline Rodrigues Robaina
Mariana Barros Genuino de Oliveira
Fernanda Freire Tovar-Moll
Roberto de Andrade Medronho
Antonio José Ledo Alves da Cunha
Joffre Amim
Arnaldo Prata-Barbosa
author_facet Marlos Melo Martins
Andréa Bittencourt Guastavino
Maria Clara de Magalhães-Barbosa
Maria Helena de Magalhães-Barbosa
Cristiane Fregonesi Dutra Garcia
Bárbara Karine Gonet Amaral
Annamaria Ciminelli Barbosa
Halina Cidrini Ferreira
Jaqueline Rodrigues Robaina
Mariana Barros Genuino de Oliveira
Fernanda Freire Tovar-Moll
Roberto de Andrade Medronho
Antonio José Ledo Alves da Cunha
Joffre Amim
Arnaldo Prata-Barbosa
author_sort Marlos Melo Martins
collection DOAJ
description This study aims to describe neurological, visual, and auditory findings in children whose mothers had confirmed Zika virus (ZIKV) infection during pregnancy, with most of these children not presenting congenital microcephaly; Methods: an observational, longitudinal, and prospective study was conducted in Rio de Janeiro, Brazil, from March 2015 to January 2017, involving children with in utero exposure to Zika virus, following from birth up to 30 months of age. Results: Of the 2882 pregnant women admitted, 116 had a suspected ZIKV infection, of whom 33 had laboratory confirmation. Only one child presented with congenital microcephaly. Despite this, neurodevelopment delay was observed in 36.4% of children evaluated, radiological abnormalities in 29.1%, auditory abnormalities in 8.3%, and ophthalmological abnormalities in 10%. Conclusions: Newborns of mothers with confirmed ZIKV infection during pregnancy may present with varying degrees of visual, auditory, and neurological impairment, despite the presence of congenital microcephaly.
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spelling doaj-art-9f39f47826264eb4ba2d0f3f736cbe172025-08-20T02:45:42ZengMDPI AGViruses1999-49152025-02-0117223810.3390/v17020238Neurological, Radiological, Visual, and Auditory Findings in Children with Intrauterine Exposure to the Zika VirusMarlos Melo Martins0Andréa Bittencourt Guastavino1Maria Clara de Magalhães-Barbosa2Maria Helena de Magalhães-Barbosa3Cristiane Fregonesi Dutra Garcia4Bárbara Karine Gonet Amaral5Annamaria Ciminelli Barbosa6Halina Cidrini Ferreira7Jaqueline Rodrigues Robaina8Mariana Barros Genuino de Oliveira9Fernanda Freire Tovar-Moll10Roberto de Andrade Medronho11Antonio José Ledo Alves da Cunha12Joffre Amim13Arnaldo Prata-Barbosa14Division of Pediatric Neurology, Martagão Gesteira Institute of Childcare and Pediatrics (IPPMG), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21941-912, RJ, BrazilNeonatal Unit, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, BrazilDepartment of Pediatrics, D’Or Institute for Research and Education (IDOR), Rio de Janeiro 22281-100, RJ, BrazilPhonoaudiology Unit, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, BrazilPhonoaudiology Unit, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, BrazilDepartment of Ophthalmology, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, BrazilDepartment of Ophthalmology, Gaffree and Guinle University Hospital, Federal University of the State of Rio de Janeiro (UNIRIO), Rio de Janeiro 20270-004, RJ, BrazilDepartment of Physiotherapy, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, BrazilDepartment of Pediatrics, D’Or Institute for Research and Education (IDOR), Rio de Janeiro 22281-100, RJ, BrazilDepartment of Pediatrics, D’Or Institute for Research and Education (IDOR), Rio de Janeiro 22281-100, RJ, BrazilDepartment of Radiology, D’Or Institute for Research and Education (IDOR), Rio de Janeiro 22281-100, RJ, BrazilDepartment of Epidemiology and Public Health, School of Medicine, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 21044-020, RJ, BrazilDepartment of Pediatrics, D’Or Institute for Research and Education (IDOR), Rio de Janeiro 22281-100, RJ, BrazilPostgraduate Program, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, BrazilPostgraduate Program, Maternity School Hospital, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro 22240-001, RJ, BrazilThis study aims to describe neurological, visual, and auditory findings in children whose mothers had confirmed Zika virus (ZIKV) infection during pregnancy, with most of these children not presenting congenital microcephaly; Methods: an observational, longitudinal, and prospective study was conducted in Rio de Janeiro, Brazil, from March 2015 to January 2017, involving children with in utero exposure to Zika virus, following from birth up to 30 months of age. Results: Of the 2882 pregnant women admitted, 116 had a suspected ZIKV infection, of whom 33 had laboratory confirmation. Only one child presented with congenital microcephaly. Despite this, neurodevelopment delay was observed in 36.4% of children evaluated, radiological abnormalities in 29.1%, auditory abnormalities in 8.3%, and ophthalmological abnormalities in 10%. Conclusions: Newborns of mothers with confirmed ZIKV infection during pregnancy may present with varying degrees of visual, auditory, and neurological impairment, despite the presence of congenital microcephaly.https://www.mdpi.com/1999-4915/17/2/238Zika virusmicrocephalyinfantile developmentradiological abnormalitiesvisual disordersauditory disorders
spellingShingle Marlos Melo Martins
Andréa Bittencourt Guastavino
Maria Clara de Magalhães-Barbosa
Maria Helena de Magalhães-Barbosa
Cristiane Fregonesi Dutra Garcia
Bárbara Karine Gonet Amaral
Annamaria Ciminelli Barbosa
Halina Cidrini Ferreira
Jaqueline Rodrigues Robaina
Mariana Barros Genuino de Oliveira
Fernanda Freire Tovar-Moll
Roberto de Andrade Medronho
Antonio José Ledo Alves da Cunha
Joffre Amim
Arnaldo Prata-Barbosa
Neurological, Radiological, Visual, and Auditory Findings in Children with Intrauterine Exposure to the Zika Virus
Viruses
Zika virus
microcephaly
infantile development
radiological abnormalities
visual disorders
auditory disorders
title Neurological, Radiological, Visual, and Auditory Findings in Children with Intrauterine Exposure to the Zika Virus
title_full Neurological, Radiological, Visual, and Auditory Findings in Children with Intrauterine Exposure to the Zika Virus
title_fullStr Neurological, Radiological, Visual, and Auditory Findings in Children with Intrauterine Exposure to the Zika Virus
title_full_unstemmed Neurological, Radiological, Visual, and Auditory Findings in Children with Intrauterine Exposure to the Zika Virus
title_short Neurological, Radiological, Visual, and Auditory Findings in Children with Intrauterine Exposure to the Zika Virus
title_sort neurological radiological visual and auditory findings in children with intrauterine exposure to the zika virus
topic Zika virus
microcephaly
infantile development
radiological abnormalities
visual disorders
auditory disorders
url https://www.mdpi.com/1999-4915/17/2/238
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