Pharmacology of Dostarlimab: A Review
Dostarlimab is a humanised anti-PD-1 immunoglobulin (IgG4) monoclonal antibody (mAb). It has a high affinity for the PD-1 receptor and effectively inhibits interactions with PD-L1 and PD-L2 by blocking their binding to the PD-1 receptor. Programmed cell death 1 (PD-1) is an immunological ch...
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| Format: | Article |
| Language: | English |
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Krupanidhi College of Pharmacy
2022-09-01
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| Series: | Journal of Pharmaceutical Research |
| Online Access: | https://jopcr.com/articles/pharmacology-of-dostarlimab-a-review |
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| _version_ | 1849230175536939008 |
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| author | Arnab Roy Akash Chaurasiya |
| author_facet | Arnab Roy Akash Chaurasiya |
| author_sort | Arnab Roy |
| collection | DOAJ |
| description | Dostarlimab is a humanised anti-PD-1 immunoglobulin (IgG4) monoclonal antibody (mAb). It has a high affinity for the PD-1 receptor and effectively inhibits interactions with PD-L1 and PD-L2 by blocking their binding to the PD-1 receptor. Programmed cell death 1 (PD-1) is an immunological checkpoint receptor that transmits inhibitory signals to limit local inflammatory responses and preserve self-tolerance. It is found on antigen-activated and fatigued T cells. When the PD-1 receptor binds to the tumor-expressed ligands PD-L1 and PD-L2, T-cell proliferation and cytokine production are suppressed. Keywords: Dostarlimab, PD1 immunoglobulin, T - cell proliferation |
| format | Article |
| id | doaj-art-9f3506919fbc4e9498fa905e10ffdeca |
| institution | Kabale University |
| issn | 0973-7200 2454-8405 |
| language | English |
| publishDate | 2022-09-01 |
| publisher | Krupanidhi College of Pharmacy |
| record_format | Article |
| series | Journal of Pharmaceutical Research |
| spelling | doaj-art-9f3506919fbc4e9498fa905e10ffdeca2025-08-21T09:34:09ZengKrupanidhi College of PharmacyJournal of Pharmaceutical Research0973-72002454-84052022-09-01212444710.18579/jopcr/v21i2.2Pharmacology of Dostarlimab: A ReviewArnab RoyAkash Chaurasiya Dostarlimab is a humanised anti-PD-1 immunoglobulin (IgG4) monoclonal antibody (mAb). It has a high affinity for the PD-1 receptor and effectively inhibits interactions with PD-L1 and PD-L2 by blocking their binding to the PD-1 receptor. Programmed cell death 1 (PD-1) is an immunological checkpoint receptor that transmits inhibitory signals to limit local inflammatory responses and preserve self-tolerance. It is found on antigen-activated and fatigued T cells. When the PD-1 receptor binds to the tumor-expressed ligands PD-L1 and PD-L2, T-cell proliferation and cytokine production are suppressed. Keywords: Dostarlimab, PD1 immunoglobulin, T - cell proliferationhttps://jopcr.com/articles/pharmacology-of-dostarlimab-a-review |
| spellingShingle | Arnab Roy Akash Chaurasiya Pharmacology of Dostarlimab: A Review Journal of Pharmaceutical Research |
| title | Pharmacology of Dostarlimab: A Review |
| title_full | Pharmacology of Dostarlimab: A Review |
| title_fullStr | Pharmacology of Dostarlimab: A Review |
| title_full_unstemmed | Pharmacology of Dostarlimab: A Review |
| title_short | Pharmacology of Dostarlimab: A Review |
| title_sort | pharmacology of dostarlimab a review |
| url | https://jopcr.com/articles/pharmacology-of-dostarlimab-a-review |
| work_keys_str_mv | AT arnabroy pharmacologyofdostarlimabareview AT akashchaurasiya pharmacologyofdostarlimabareview |