Genetic and epigenetic regulation of Treg cell fitness by autism-related chromatin remodeler CHD8

Genetic and epigenetic regulation of Treg cell fitness by autism-related chromatin remodeler CHD8

Abstract Background Chromatin remodeler chromodomain helicase DNA-binding protein 8 (CHD8) defines a subtype of autism that is associated with immune disorders. It remains unknown whether CHD8 plays a cell-intrinsic role in immune cells such as regulatory T cells (Tregs) that maintain immune toleran...

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Bibliographic Details
Main Authors: Jun-Qi Yang, Chen Wang, Ramesh C. Nayak, Manohar Kolla, Mingjun Cai, Mario Pujato, Yi Zheng, Q. Richard Lu, Fukun Guo
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Cellular & Molecular Biology Letters
Subjects:
CHD8
Treg
Treg plasticity
Chromatin remodeling
Gene expression
Online Access:https://doi.org/10.1186/s11658-025-00711-z
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