Acute Kidney Injury and Acute Liver Failure in Leptospira Infection and Weil’s Syndrome
Leptospirosis is considered a zoonosis acquired predominantly from contaminated surfaces and water, more commonly in emerging countries with limited sanitary conditions. Leptospira in the host unleashes an immune response that explains the symptoms and clinical signs; once it reaches the kidney and...
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| Format: | Article |
| Language: | English |
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Troika Publisher
2020-06-01
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| Series: | Journal of Renal and Hepatic Disorders |
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| Online Access: | https://jrenhep.com/index.php/jrenhep/article/view/75 |
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| author | Jonathan S Chávez-Iñiguez Guillermo Garcia-Garcia Jose Said Cabrera-Aguilar Juan Armendáriz-Borunda |
| author_facet | Jonathan S Chávez-Iñiguez Guillermo Garcia-Garcia Jose Said Cabrera-Aguilar Juan Armendáriz-Borunda |
| author_sort | Jonathan S Chávez-Iñiguez |
| collection | DOAJ |
| description | Leptospirosis is considered a zoonosis acquired predominantly from contaminated surfaces and water, more commonly in emerging countries with limited sanitary conditions. Leptospira in the host unleashes an immune response that explains the symptoms and clinical signs; once it reaches the kidney and liver tissue, it can manifest with alterations that lead to acute and chronic diseases in both organs. Weil’s syndrome is the best known clinical manifestation with jaundice and acute kidney injury that could lead to multiple organ failure and death. For its diagnosis, there are simplified scores such as the SPiRO score, the microbiological criteria by microscopy or serological tests; the treatment focuses on antibiotics and, if necessary, provides organic support until the infection is curtailed. The purpose of this review was to address the impact of Lep-tospira infection on the kidney and liver, the mechanisms of organ damage, the clinical presentation, and diagnosis and management of this disease. |
| format | Article |
| id | doaj-art-9f32eea3d74b4ab98b64a6a7a4724935 |
| institution | DOAJ |
| issn | 2207-3744 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Troika Publisher |
| record_format | Article |
| series | Journal of Renal and Hepatic Disorders |
| spelling | doaj-art-9f32eea3d74b4ab98b64a6a7a47249352025-08-20T02:51:48ZengTroika PublisherJournal of Renal and Hepatic Disorders2207-37442020-06-014210.15586/jrenhep.2020.75Acute Kidney Injury and Acute Liver Failure in Leptospira Infection and Weil’s Syndrome Jonathan S Chávez-Iñiguez0 Guillermo Garcia-Garcia1 Jose Said Cabrera-Aguilar2Juan Armendáriz-Borunda3Hospital Civil de Guadalajara Fray Antonio Alcalde, MexicoHospital Civil de Guadalajara Fray Antonio Alcalde, MexicoHospital Civil de Guadalajara Fray Antonio Alcalde, MexicoUniversidad de Guadalajara, MexicoLeptospirosis is considered a zoonosis acquired predominantly from contaminated surfaces and water, more commonly in emerging countries with limited sanitary conditions. Leptospira in the host unleashes an immune response that explains the symptoms and clinical signs; once it reaches the kidney and liver tissue, it can manifest with alterations that lead to acute and chronic diseases in both organs. Weil’s syndrome is the best known clinical manifestation with jaundice and acute kidney injury that could lead to multiple organ failure and death. For its diagnosis, there are simplified scores such as the SPiRO score, the microbiological criteria by microscopy or serological tests; the treatment focuses on antibiotics and, if necessary, provides organic support until the infection is curtailed. The purpose of this review was to address the impact of Lep-tospira infection on the kidney and liver, the mechanisms of organ damage, the clinical presentation, and diagnosis and management of this disease.https://jrenhep.com/index.php/jrenhep/article/view/75Leptospirosis, acute kidney injury, acute liver failure. |
| spellingShingle | Jonathan S Chávez-Iñiguez Guillermo Garcia-Garcia Jose Said Cabrera-Aguilar Juan Armendáriz-Borunda Acute Kidney Injury and Acute Liver Failure in Leptospira Infection and Weil’s Syndrome Journal of Renal and Hepatic Disorders Leptospirosis, acute kidney injury, acute liver failure. |
| title | Acute Kidney Injury and Acute Liver Failure in Leptospira Infection and Weil’s Syndrome |
| title_full | Acute Kidney Injury and Acute Liver Failure in Leptospira Infection and Weil’s Syndrome |
| title_fullStr | Acute Kidney Injury and Acute Liver Failure in Leptospira Infection and Weil’s Syndrome |
| title_full_unstemmed | Acute Kidney Injury and Acute Liver Failure in Leptospira Infection and Weil’s Syndrome |
| title_short | Acute Kidney Injury and Acute Liver Failure in Leptospira Infection and Weil’s Syndrome |
| title_sort | acute kidney injury and acute liver failure in leptospira infection and weil s syndrome |
| topic | Leptospirosis, acute kidney injury, acute liver failure. |
| url | https://jrenhep.com/index.php/jrenhep/article/view/75 |
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