Heterotropic Activation of Cytochrome P450 3A4 by Perillyl Alcohol

Heterotropic Activation of Cytochrome P450 3A4 by Perillyl Alcohol

<b>Background/Objectives</b>: Perillyl alcohol (POH), a monoterpene natural product derived from the essential oils of plants such as perilla (<i>Perilla frutescens</i>), is currently in phase I and II clinical trials as a chemotherapeutic agent. In this study, we investigate...

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Bibliographic Details
Main Authors: Ji Hyeon Ryu, Jieun Yu, Jang Su Jeon, Seongyea Jo, Soo Min Lee, Hyemin Kim, Han-Jin Park, Soo Jin Oh, Sang Kyum Kim
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Pharmaceutics
Subjects:
heterotropic activation
CYP3A4
perillyl alcohol
human hepatic organoids
drug interaction
Online Access:https://www.mdpi.com/1999-4923/16/12/1581
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