Angiogenesis and multiple myeloma: Exploring prognostic potential of adrenomedullin
Abstract Background Adrenomedullin (AM) is a multifunctional peptide which under basal conditions mainly regulates vasodilation and maintains vascular integrity but is also implicated in the pathogenesis of several malignancies, including multiple myeloma (MM). It has been shown that adrenomedullin...
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| Format: | Article |
| Language: | English |
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Wiley
2024-09-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.70250 |
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| author | Angelos Giannakoulas Panagiotis Stoikos Evangelia Kouvata Katerina M. Kontouli Georgios Fotiadis Georgia Stefani Grigorios D. Amoutzias George Vassilopoulos Nikolaos Giannakoulas |
| author_facet | Angelos Giannakoulas Panagiotis Stoikos Evangelia Kouvata Katerina M. Kontouli Georgios Fotiadis Georgia Stefani Grigorios D. Amoutzias George Vassilopoulos Nikolaos Giannakoulas |
| author_sort | Angelos Giannakoulas |
| collection | DOAJ |
| description | Abstract Background Adrenomedullin (AM) is a multifunctional peptide which under basal conditions mainly regulates vasodilation and maintains vascular integrity but is also implicated in the pathogenesis of several malignancies, including multiple myeloma (MM). It has been shown that adrenomedullin is expressed by human myeloma cell lines and that it enhances MM‐driven angiogenesis. However, the clinical impact of AM remains unknown. Materials and Methods On that basis, we enrolled 32 newly diagnosed multiple myeloma patients (NDMM) and studied the potential of AM as a prognostic biomarker. Results We report that elevated levels of AM trend with suboptimal treatment response and inferior survival of NDMM patients. |
| format | Article |
| id | doaj-art-9f32637016ca418faeee22daf9233357 |
| institution | DOAJ |
| issn | 2045-7634 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-9f32637016ca418faeee22daf92333572025-08-20T03:13:01ZengWileyCancer Medicine2045-76342024-09-011318n/an/a10.1002/cam4.70250Angiogenesis and multiple myeloma: Exploring prognostic potential of adrenomedullinAngelos Giannakoulas0Panagiotis Stoikos1Evangelia Kouvata2Katerina M. Kontouli3Georgios Fotiadis4Georgia Stefani5Grigorios D. Amoutzias6George Vassilopoulos7Nikolaos Giannakoulas8Laboratory of Hematology Department, Faculty of Medicine University of Thessaly Larissa GreeceLaboratory of Hematology Department, Faculty of Medicine University of Thessaly Larissa GreeceHematology Department University Hospital of Larissa Larissa GreeceLaboratory of Hygiene and Epidemiology, Faculty of Medicine University of Thessaly Larissa GreeceHematology Department University Hospital of Larissa Larissa GreeceHematology Department University Hospital of Larissa Larissa GreeceBioinformatics Laboratory, Department of Biochemistry & Biotechnology School of Health Sciences, University of Thessaly Larissa GreeceHematology Department University Hospital of Larissa Larissa GreeceHematology Department University Hospital of Larissa Larissa GreeceAbstract Background Adrenomedullin (AM) is a multifunctional peptide which under basal conditions mainly regulates vasodilation and maintains vascular integrity but is also implicated in the pathogenesis of several malignancies, including multiple myeloma (MM). It has been shown that adrenomedullin is expressed by human myeloma cell lines and that it enhances MM‐driven angiogenesis. However, the clinical impact of AM remains unknown. Materials and Methods On that basis, we enrolled 32 newly diagnosed multiple myeloma patients (NDMM) and studied the potential of AM as a prognostic biomarker. Results We report that elevated levels of AM trend with suboptimal treatment response and inferior survival of NDMM patients.https://doi.org/10.1002/cam4.70250adrenomedullinangiogenesismultiple myelomaprognostication |
| spellingShingle | Angelos Giannakoulas Panagiotis Stoikos Evangelia Kouvata Katerina M. Kontouli Georgios Fotiadis Georgia Stefani Grigorios D. Amoutzias George Vassilopoulos Nikolaos Giannakoulas Angiogenesis and multiple myeloma: Exploring prognostic potential of adrenomedullin Cancer Medicine adrenomedullin angiogenesis multiple myeloma prognostication |
| title | Angiogenesis and multiple myeloma: Exploring prognostic potential of adrenomedullin |
| title_full | Angiogenesis and multiple myeloma: Exploring prognostic potential of adrenomedullin |
| title_fullStr | Angiogenesis and multiple myeloma: Exploring prognostic potential of adrenomedullin |
| title_full_unstemmed | Angiogenesis and multiple myeloma: Exploring prognostic potential of adrenomedullin |
| title_short | Angiogenesis and multiple myeloma: Exploring prognostic potential of adrenomedullin |
| title_sort | angiogenesis and multiple myeloma exploring prognostic potential of adrenomedullin |
| topic | adrenomedullin angiogenesis multiple myeloma prognostication |
| url | https://doi.org/10.1002/cam4.70250 |
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