Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs
Smart polymers like pH sensitive systems can improve different pharmacological treatment. In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different proportions of 2-(diisopropylamino) ethyl methacrylate (DPA) and different amounts of cross-linker agent, eth...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Budapest University of Technology and Economics
2015-06-01
|
| Series: | eXPRESS Polymer Letters |
| Subjects: | |
| Online Access: | http://www.expresspolymlett.com/letolt.php?file=EPL-0005879&mi=cd |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850055978924376064 |
|---|---|
| author | P. A. Faccia F. M. Pardini J. I. Amalvy |
| author_facet | P. A. Faccia F. M. Pardini J. I. Amalvy |
| author_sort | P. A. Faccia |
| collection | DOAJ |
| description | Smart polymers like pH sensitive systems can improve different pharmacological treatment. In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different proportions of 2-(diisopropylamino) ethyl methacrylate (DPA) and different amounts of cross-linker agent, ethylene glycol dimethacrylate (EGDMA) are evaluated as pH-sensitive drug delivery systems for potential application in ophthalmic therapies. A detailed characterization of the pH-responsive behavior was performed by swelling studies and scanning electron microscopy (SEM) analysis. Drug loading and release studies at different pH values were evaluated using Rhodamine 6G (Rh6G) as a model drug. The interaction between Rh6G and hydrogels was studied by Fourier Transform Infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The results show that the presence of DPA in the copolymers confers pH-responsive properties to the polymer, as noted in swelling and SEM studies, when the pH decreases below 7.40 the swelling degree increases and a porous morphology is observed. The apparent pKa of copolymers was estimated between 6.80 and 7.17 depending on the composition. The amount of Rh6G loaded depends mainly on the medium pH and the interaction between the drug and the copolymers, observed by SEM and FTIR spectrum. The release of Rh6G of copolymers p(HEMA/DPA) show a normal Fickian or anomalous diffusion behavior at different pH values, depending on the HEMA/DPA ratio. |
| format | Article |
| id | doaj-art-9f304e2e50ee4f378d3223f11a9d8be9 |
| institution | DOAJ |
| issn | 1788-618X |
| language | English |
| publishDate | 2015-06-01 |
| publisher | Budapest University of Technology and Economics |
| record_format | Article |
| series | eXPRESS Polymer Letters |
| spelling | doaj-art-9f304e2e50ee4f378d3223f11a9d8be92025-08-20T02:51:49ZengBudapest University of Technology and EconomicseXPRESS Polymer Letters1788-618X2015-06-019655456610.3144/expresspolymlett.2015.52Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugsP. A. FacciaF. M. PardiniJ. I. AmalvySmart polymers like pH sensitive systems can improve different pharmacological treatment. In this work the behavior of copolymers containing 2-hydroxyethyl methacrylate (HEMA) with different proportions of 2-(diisopropylamino) ethyl methacrylate (DPA) and different amounts of cross-linker agent, ethylene glycol dimethacrylate (EGDMA) are evaluated as pH-sensitive drug delivery systems for potential application in ophthalmic therapies. A detailed characterization of the pH-responsive behavior was performed by swelling studies and scanning electron microscopy (SEM) analysis. Drug loading and release studies at different pH values were evaluated using Rhodamine 6G (Rh6G) as a model drug. The interaction between Rh6G and hydrogels was studied by Fourier Transform Infrared (FTIR) spectroscopy and scanning electron microscopy (SEM). The results show that the presence of DPA in the copolymers confers pH-responsive properties to the polymer, as noted in swelling and SEM studies, when the pH decreases below 7.40 the swelling degree increases and a porous morphology is observed. The apparent pKa of copolymers was estimated between 6.80 and 7.17 depending on the composition. The amount of Rh6G loaded depends mainly on the medium pH and the interaction between the drug and the copolymers, observed by SEM and FTIR spectrum. The release of Rh6G of copolymers p(HEMA/DPA) show a normal Fickian or anomalous diffusion behavior at different pH values, depending on the HEMA/DPA ratio.http://www.expresspolymlett.com/letolt.php?file=EPL-0005879&mi=cdSmart polymers2-hydroxyethyl methacrylate2-(diisoproylamino)ethyl methapH-sensitive hydrogelsdrug delivery systems |
| spellingShingle | P. A. Faccia F. M. Pardini J. I. Amalvy Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs eXPRESS Polymer Letters Smart polymers 2-hydroxyethyl methacrylate 2-(diisoproylamino)ethyl metha pH-sensitive hydrogels drug delivery systems |
| title | Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs |
| title_full | Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs |
| title_fullStr | Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs |
| title_full_unstemmed | Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs |
| title_short | Evaluation of pH-sensitive poly(2-hydroxyethyl methacrylate-co-2-(diisopropylamino)ethyl methacrylate) copolymers as drug delivery systems for potential applications in ophthalmic therapies/ocular delivery of drugs |
| title_sort | evaluation of ph sensitive poly 2 hydroxyethyl methacrylate co 2 diisopropylamino ethyl methacrylate copolymers as drug delivery systems for potential applications in ophthalmic therapies ocular delivery of drugs |
| topic | Smart polymers 2-hydroxyethyl methacrylate 2-(diisoproylamino)ethyl metha pH-sensitive hydrogels drug delivery systems |
| url | http://www.expresspolymlett.com/letolt.php?file=EPL-0005879&mi=cd |
| work_keys_str_mv | AT pafaccia evaluationofphsensitivepoly2hydroxyethylmethacrylateco2diisopropylaminoethylmethacrylatecopolymersasdrugdeliverysystemsforpotentialapplicationsinophthalmictherapiesoculardeliveryofdrugs AT fmpardini evaluationofphsensitivepoly2hydroxyethylmethacrylateco2diisopropylaminoethylmethacrylatecopolymersasdrugdeliverysystemsforpotentialapplicationsinophthalmictherapiesoculardeliveryofdrugs AT jiamalvy evaluationofphsensitivepoly2hydroxyethylmethacrylateco2diisopropylaminoethylmethacrylatecopolymersasdrugdeliverysystemsforpotentialapplicationsinophthalmictherapiesoculardeliveryofdrugs |