Long term survival of advanced hepatoid adenocarcinoma of lung secondary to idiopathic pulmonary fibrosis: a case report
BackgroundAlpha-fetoprotein (AFP)-producing hepatoid adenocarcinoma of lung (HAL) is a rare type of lung cancer, with its characteristics being not yet fully clarified. We recently encountered a case of HAL combined with idiopathic pulmonary fibrosis (IPF), which has never been reported.Case present...
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| Format: | Article |
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1487334/full |
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| author | Xiaoli Wang Xiaoli Wang Nan Wei Nan Wei Huizhen Yang Huizhen Yang Xiaoyan Wang Xiaoju Zhang Xiaoju Zhang Qianqian Zhang Qianqian Zhang |
| author_facet | Xiaoli Wang Xiaoli Wang Nan Wei Nan Wei Huizhen Yang Huizhen Yang Xiaoyan Wang Xiaoju Zhang Xiaoju Zhang Qianqian Zhang Qianqian Zhang |
| author_sort | Xiaoli Wang |
| collection | DOAJ |
| description | BackgroundAlpha-fetoprotein (AFP)-producing hepatoid adenocarcinoma of lung (HAL) is a rare type of lung cancer, with its characteristics being not yet fully clarified. We recently encountered a case of HAL combined with idiopathic pulmonary fibrosis (IPF), which has never been reported.Case presentationA 66-year-old man consulted our hospital with a chief complaint of cough. Chest computed tomography (CT) revealed multiple nodules measuring from 8mm to 20mm in diameter located in bilateral lung, along with an enlarged left hilar lymph node. CT-guided percutaneous lung biopsy confirmed the diagnosis of AFP-producing primary HAL combined with IPF. Systemic treatment according to guidelines for advanced non-small cell lung cancer resulted in a long-term survival.ConclusionsThis case report documents the first occurrence and prognosis of AFP-producing HAL in a patient with IPF. The long-term survival brought by the diagnosis and treatment model in our case may provide significant prognostic value for this rare condition. |
| format | Article |
| id | doaj-art-9f2d4189b4aa47759fc0cf6428236113 |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-9f2d4189b4aa47759fc0cf64282361132025-02-04T05:27:58ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-02-011510.3389/fonc.2025.14873341487334Long term survival of advanced hepatoid adenocarcinoma of lung secondary to idiopathic pulmonary fibrosis: a case reportXiaoli Wang0Xiaoli Wang1Nan Wei2Nan Wei3Huizhen Yang4Huizhen Yang5Xiaoyan Wang6Xiaoju Zhang7Xiaoju Zhang8Qianqian Zhang9Qianqian Zhang10Department of Respiratory and Critical Care Medicine, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, ChinaHenan International Joint Laboratory of Diagnosis and Treatment for Pulmonary Nodules, Zhengzhou University People's Hospital, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Respiratory and Critical Care Medicine, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, ChinaHenan International Joint Laboratory of Diagnosis and Treatment for Pulmonary Nodules, Zhengzhou University People's Hospital, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Respiratory and Critical Care Medicine, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, ChinaHenan International Joint Laboratory of Diagnosis and Treatment for Pulmonary Nodules, Zhengzhou University People's Hospital, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Pathology, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, ChinaDepartment of Respiratory and Critical Care Medicine, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, ChinaHenan International Joint Laboratory of Diagnosis and Treatment for Pulmonary Nodules, Zhengzhou University People's Hospital, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaDepartment of Respiratory and Critical Care Medicine, Zhengzhou University People's Hospital, Henan Provincial People's Hospital, Zhengzhou, Henan, ChinaHenan International Joint Laboratory of Diagnosis and Treatment for Pulmonary Nodules, Zhengzhou University People's Hospital, Henan Provincial People’s Hospital, Zhengzhou, Henan, ChinaBackgroundAlpha-fetoprotein (AFP)-producing hepatoid adenocarcinoma of lung (HAL) is a rare type of lung cancer, with its characteristics being not yet fully clarified. We recently encountered a case of HAL combined with idiopathic pulmonary fibrosis (IPF), which has never been reported.Case presentationA 66-year-old man consulted our hospital with a chief complaint of cough. Chest computed tomography (CT) revealed multiple nodules measuring from 8mm to 20mm in diameter located in bilateral lung, along with an enlarged left hilar lymph node. CT-guided percutaneous lung biopsy confirmed the diagnosis of AFP-producing primary HAL combined with IPF. Systemic treatment according to guidelines for advanced non-small cell lung cancer resulted in a long-term survival.ConclusionsThis case report documents the first occurrence and prognosis of AFP-producing HAL in a patient with IPF. The long-term survival brought by the diagnosis and treatment model in our case may provide significant prognostic value for this rare condition.https://www.frontiersin.org/articles/10.3389/fonc.2025.1487334/fullhepatoid adenocarcinomalung canceridiopathic pulmonary fibrosisalpha-fetoproteinimmune checkpoint inhibitor |
| spellingShingle | Xiaoli Wang Xiaoli Wang Nan Wei Nan Wei Huizhen Yang Huizhen Yang Xiaoyan Wang Xiaoju Zhang Xiaoju Zhang Qianqian Zhang Qianqian Zhang Long term survival of advanced hepatoid adenocarcinoma of lung secondary to idiopathic pulmonary fibrosis: a case report Frontiers in Oncology hepatoid adenocarcinoma lung cancer idiopathic pulmonary fibrosis alpha-fetoprotein immune checkpoint inhibitor |
| title | Long term survival of advanced hepatoid adenocarcinoma of lung secondary to idiopathic pulmonary fibrosis: a case report |
| title_full | Long term survival of advanced hepatoid adenocarcinoma of lung secondary to idiopathic pulmonary fibrosis: a case report |
| title_fullStr | Long term survival of advanced hepatoid adenocarcinoma of lung secondary to idiopathic pulmonary fibrosis: a case report |
| title_full_unstemmed | Long term survival of advanced hepatoid adenocarcinoma of lung secondary to idiopathic pulmonary fibrosis: a case report |
| title_short | Long term survival of advanced hepatoid adenocarcinoma of lung secondary to idiopathic pulmonary fibrosis: a case report |
| title_sort | long term survival of advanced hepatoid adenocarcinoma of lung secondary to idiopathic pulmonary fibrosis a case report |
| topic | hepatoid adenocarcinoma lung cancer idiopathic pulmonary fibrosis alpha-fetoprotein immune checkpoint inhibitor |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1487334/full |
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