Neonatal Natural Killer Cell Function: Relevance to Antiviral Immune Defense
Neonates are particularly susceptible to various pathogens compared to adults, which is attributed in part to their immature innate and adaptive immunity. Natural killer cells provide first-line innate immune reactions against virus-infected cells without prior sensitization. This review updates phe...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2013/427696 |
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| _version_ | 1850179258917322752 |
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| author | Yen-Chang Lee Syh-Jae Lin |
| author_facet | Yen-Chang Lee Syh-Jae Lin |
| author_sort | Yen-Chang Lee |
| collection | DOAJ |
| description | Neonates are particularly susceptible to various pathogens compared to adults, which is attributed in part to their immature innate and adaptive immunity. Natural killer cells provide first-line innate immune reactions against virus-infected cells without prior sensitization. This review updates phenotypic and functional deficiencies of neonatal cells compared to their adult counterparts and their clinical implications. |
| format | Article |
| id | doaj-art-9f2a3514cd6740f1a9250ed677175b79 |
| institution | OA Journals |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-9f2a3514cd6740f1a9250ed677175b792025-08-20T02:18:33ZengWileyClinical and Developmental Immunology1740-25221740-25302013-01-01201310.1155/2013/427696427696Neonatal Natural Killer Cell Function: Relevance to Antiviral Immune DefenseYen-Chang Lee0Syh-Jae Lin1Department of Obstetrics/Gynecology, Chang Gung Memorial Hospital, Taoyuan 333, TaiwanDivision of Asthma, Allergy, and Rheumatology, Department of Pediatrics, Chang Gung Children’s Hospital, College of Medicine, Chang Gung University, Taoyuan 333, TaiwanNeonates are particularly susceptible to various pathogens compared to adults, which is attributed in part to their immature innate and adaptive immunity. Natural killer cells provide first-line innate immune reactions against virus-infected cells without prior sensitization. This review updates phenotypic and functional deficiencies of neonatal cells compared to their adult counterparts and their clinical implications.http://dx.doi.org/10.1155/2013/427696 |
| spellingShingle | Yen-Chang Lee Syh-Jae Lin Neonatal Natural Killer Cell Function: Relevance to Antiviral Immune Defense Clinical and Developmental Immunology |
| title | Neonatal Natural Killer Cell Function: Relevance to Antiviral Immune Defense |
| title_full | Neonatal Natural Killer Cell Function: Relevance to Antiviral Immune Defense |
| title_fullStr | Neonatal Natural Killer Cell Function: Relevance to Antiviral Immune Defense |
| title_full_unstemmed | Neonatal Natural Killer Cell Function: Relevance to Antiviral Immune Defense |
| title_short | Neonatal Natural Killer Cell Function: Relevance to Antiviral Immune Defense |
| title_sort | neonatal natural killer cell function relevance to antiviral immune defense |
| url | http://dx.doi.org/10.1155/2013/427696 |
| work_keys_str_mv | AT yenchanglee neonatalnaturalkillercellfunctionrelevancetoantiviralimmunedefense AT syhjaelin neonatalnaturalkillercellfunctionrelevancetoantiviralimmunedefense |