Causal role of ischemic heart disease in ovarian cancer subtypes
Abstract Background Ischemic heart disease (IHD) may share biological mechanisms with cancer, including ovarian cancer, through pathways such as chronic inflammation and oxidative stress. However, the relationship between IHD and ovarian cancer subtypes remains unclear. This study used Mendelian ran...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Springer
2025-01-01
|
| Series: | Discover Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1007/s12672-025-01824-9 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585653615853568 |
|---|---|
| author | Jianhai Chen Huabin He Ling Gao |
| author_facet | Jianhai Chen Huabin He Ling Gao |
| author_sort | Jianhai Chen |
| collection | DOAJ |
| description | Abstract Background Ischemic heart disease (IHD) may share biological mechanisms with cancer, including ovarian cancer, through pathways such as chronic inflammation and oxidative stress. However, the relationship between IHD and ovarian cancer subtypes remains unclear. This study used Mendelian randomization (MR) to explore potential causal associations. Methods A two-sample MR analysis was conducted using genetic instruments for IHD from large-scale genome-wide association studies (GWAS). The inverse-variance weighted (IVW) method was used as the primary analysis, supported by MR-Egger, weighted median, and MR-PRESSO for sensitivity analyses. Results No significant association was found between IHD and overall ovarian cancer risk (OR = 0.97, 95% CI 0.92–1.03, P = 0.378). However, IHD was linked to a reduced risk of endometrioid ovarian cancer (OR = 0.86, 95% CI 0.76–0.98, P = 0.027). No associations were observed for serous, mucinous, or clear cell ovarian cancers. Sensitivity analyses confirmed robust findings. Conclusions IHD may confer a protective effect against endometrioid ovarian cancer but does not influence overall ovarian cancer risk. These findings highlight the need for further research into subtype-specific mechanisms. |
| format | Article |
| id | doaj-art-9f28de315abc47d0a0f880ea23e5f8c4 |
| institution | Kabale University |
| issn | 2730-6011 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Springer |
| record_format | Article |
| series | Discover Oncology |
| spelling | doaj-art-9f28de315abc47d0a0f880ea23e5f8c42025-01-26T12:39:42ZengSpringerDiscover Oncology2730-60112025-01-011611910.1007/s12672-025-01824-9Causal role of ischemic heart disease in ovarian cancer subtypesJianhai Chen0Huabin He1Ling Gao2Department of Cardiovascular Medicine, Jiu Jiang NO.1 People’s HospitalDepartment of Cardiovascular Medicine, Jiu Jiang NO.1 People’s HospitalDepartment of Cardiovascular Medicine, Jiu Jiang NO.1 People’s HospitalAbstract Background Ischemic heart disease (IHD) may share biological mechanisms with cancer, including ovarian cancer, through pathways such as chronic inflammation and oxidative stress. However, the relationship between IHD and ovarian cancer subtypes remains unclear. This study used Mendelian randomization (MR) to explore potential causal associations. Methods A two-sample MR analysis was conducted using genetic instruments for IHD from large-scale genome-wide association studies (GWAS). The inverse-variance weighted (IVW) method was used as the primary analysis, supported by MR-Egger, weighted median, and MR-PRESSO for sensitivity analyses. Results No significant association was found between IHD and overall ovarian cancer risk (OR = 0.97, 95% CI 0.92–1.03, P = 0.378). However, IHD was linked to a reduced risk of endometrioid ovarian cancer (OR = 0.86, 95% CI 0.76–0.98, P = 0.027). No associations were observed for serous, mucinous, or clear cell ovarian cancers. Sensitivity analyses confirmed robust findings. Conclusions IHD may confer a protective effect against endometrioid ovarian cancer but does not influence overall ovarian cancer risk. These findings highlight the need for further research into subtype-specific mechanisms.https://doi.org/10.1007/s12672-025-01824-9Ischemic heart diseaseOvarian cancerGWASMendelian randomizationGenetic epidemiology |
| spellingShingle | Jianhai Chen Huabin He Ling Gao Causal role of ischemic heart disease in ovarian cancer subtypes Discover Oncology Ischemic heart disease Ovarian cancer GWAS Mendelian randomization Genetic epidemiology |
| title | Causal role of ischemic heart disease in ovarian cancer subtypes |
| title_full | Causal role of ischemic heart disease in ovarian cancer subtypes |
| title_fullStr | Causal role of ischemic heart disease in ovarian cancer subtypes |
| title_full_unstemmed | Causal role of ischemic heart disease in ovarian cancer subtypes |
| title_short | Causal role of ischemic heart disease in ovarian cancer subtypes |
| title_sort | causal role of ischemic heart disease in ovarian cancer subtypes |
| topic | Ischemic heart disease Ovarian cancer GWAS Mendelian randomization Genetic epidemiology |
| url | https://doi.org/10.1007/s12672-025-01824-9 |
| work_keys_str_mv | AT jianhaichen causalroleofischemicheartdiseaseinovariancancersubtypes AT huabinhe causalroleofischemicheartdiseaseinovariancancersubtypes AT linggao causalroleofischemicheartdiseaseinovariancancersubtypes |