Keeping the Ductus Arteriosus Patent: Current Strategy and Perspectives
Patent ductus arteriosus (PDA) continues to be a significant finding among infants, as well as adults. What is widely considered to be a problem though, in a group of patients with congenital heart disease, it is the only lifeline. We will initially study the anatomical and biochemical mechanisms af...
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MDPI AG
2025-01-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/15/3/241 |
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| author | Anastasios Chatziantoniou Filippos-Paschalis Rorris George Samanidis Meletios Kanakis |
| author_facet | Anastasios Chatziantoniou Filippos-Paschalis Rorris George Samanidis Meletios Kanakis |
| author_sort | Anastasios Chatziantoniou |
| collection | DOAJ |
| description | Patent ductus arteriosus (PDA) continues to be a significant finding among infants, as well as adults. What is widely considered to be a problem though, in a group of patients with congenital heart disease, it is the only lifeline. We will initially study the anatomical and biochemical mechanisms affecting the PDA. The main focus of this review is on ductal-dependent congenital heart disease and biochemical and pharmacological approaches to maintaining ductus arteriosus patency, as well as surgical and interventional options for maintaining circulation. The present review aims to highlight gaps in the knowledge regarding the multifunctional role of ductus arteriosus endothelium and possibly propose a new approach to pharmacological maintenance of ductus arteriosus patency. |
| format | Article |
| id | doaj-art-9f28c80a6edf4e8eba92499c66126b34 |
| institution | OA Journals |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj-art-9f28c80a6edf4e8eba92499c66126b342025-08-20T02:12:38ZengMDPI AGDiagnostics2075-44182025-01-0115324110.3390/diagnostics15030241Keeping the Ductus Arteriosus Patent: Current Strategy and PerspectivesAnastasios Chatziantoniou0Filippos-Paschalis Rorris1George Samanidis2Meletios Kanakis3Department of Cardiology, Onassis Hospital, 17674 Athens, GreeceDepartment of Pediatric and Congenital Heart Surgery, Onassis Hospital, 17674 Athens, GreeceDepartment of Cardiac Surgery, Onassis Hospital, 17674 Athens, GreeceDepartment of Pediatric and Congenital Heart Surgery, Onassis Hospital, 17674 Athens, GreecePatent ductus arteriosus (PDA) continues to be a significant finding among infants, as well as adults. What is widely considered to be a problem though, in a group of patients with congenital heart disease, it is the only lifeline. We will initially study the anatomical and biochemical mechanisms affecting the PDA. The main focus of this review is on ductal-dependent congenital heart disease and biochemical and pharmacological approaches to maintaining ductus arteriosus patency, as well as surgical and interventional options for maintaining circulation. The present review aims to highlight gaps in the knowledge regarding the multifunctional role of ductus arteriosus endothelium and possibly propose a new approach to pharmacological maintenance of ductus arteriosus patency.https://www.mdpi.com/2075-4418/15/3/241ductus arteriosuscongenital heart diseaseductal-dependent circulationsingle ventricle physiologyBlalock–Taussig shunt |
| spellingShingle | Anastasios Chatziantoniou Filippos-Paschalis Rorris George Samanidis Meletios Kanakis Keeping the Ductus Arteriosus Patent: Current Strategy and Perspectives Diagnostics ductus arteriosus congenital heart disease ductal-dependent circulation single ventricle physiology Blalock–Taussig shunt |
| title | Keeping the Ductus Arteriosus Patent: Current Strategy and Perspectives |
| title_full | Keeping the Ductus Arteriosus Patent: Current Strategy and Perspectives |
| title_fullStr | Keeping the Ductus Arteriosus Patent: Current Strategy and Perspectives |
| title_full_unstemmed | Keeping the Ductus Arteriosus Patent: Current Strategy and Perspectives |
| title_short | Keeping the Ductus Arteriosus Patent: Current Strategy and Perspectives |
| title_sort | keeping the ductus arteriosus patent current strategy and perspectives |
| topic | ductus arteriosus congenital heart disease ductal-dependent circulation single ventricle physiology Blalock–Taussig shunt |
| url | https://www.mdpi.com/2075-4418/15/3/241 |
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