Loss of β2-integrin function results in metabolic reprogramming of dendritic cells, leading to increased dendritic cell functionality and anti-tumor responses

Loss of β2-integrin function results in metabolic reprogramming of dendritic cells, leading to increased dendritic cell functionality and anti-tumor responses

Dendritic cells (DCs) are the main antigen presenting cells of the immune system and are essential for anti-tumor responses. DC-based immunotherapies are used in cancer treatment, but their functionality is not optimized and their clinical efficacy is currently limited. Approaches to improve DC func...

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Bibliographic Details
Main Authors: Heidi Harjunpää, Riku Somermäki, Guillem Saldo Rubio, Manlio Fusciello, Sara Feola, Imrul Faisal, Anni I Nieminen, Liang Wang, Marc Llort Asens, Hongxia Zhao, Ove Eriksson, Vincenzo Cerullo, Susanna C Fagerholm
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:OncoImmunology
Subjects:
Integrin
dendritic cell
cancer immunotherapy
cell metabolism
cell adhesion
CCR7
Online Access:https://www.tandfonline.com/doi/10.1080/2162402X.2024.2369373
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