Role of HLA alleles polymorphism in systemic lupus erythematosus: A prospective study from North India
Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder and has complex etiopathogenesis. The most appropriate hypothesis states that genetic susceptibility in the presence of environmental risk factors predisposes to SLE. HLA class II alleles are critical to immune response...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2023-07-01
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| Series: | Indian Journal of Pathology and Microbiology |
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| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_764_21 |
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| author | Ranjan S. Rana Bitan Naik Mahima Yadav Usha Singh Anup Singh Shailja Singh |
| author_facet | Ranjan S. Rana Bitan Naik Mahima Yadav Usha Singh Anup Singh Shailja Singh |
| author_sort | Ranjan S. Rana |
| collection | DOAJ |
| description | Background:
Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder and has complex etiopathogenesis. The most appropriate hypothesis states that genetic susceptibility in the presence of environmental risk factors predisposes to SLE. HLA class II alleles are critical to immune response and are highly polymorphic. Various alleles in HLA-DR and -DQ regions were analyzed in SLE patients and healthy controls to see their role in susceptibility or protection to SLE.
Materials and Methods:
This was a prospective observational study, in which a total of 100 SLE patients and 100 controls were analyzed. HLA typing was done by polymerase chain reaction (PCR)-sequence-specific oligonucleotide (SSO) method (SSO probe).
Results:
DRβ1*0301 was significantly increased in SLE patients when compared to controls and had the highest odds ratio. Other risk factor alleles found to be increased were DRβ1*0701, DQβ1*0202, and DQβ1*0301, which had a significant positive association with SLE, suggesting their role in susceptibility to SLE. In contrast, DRβ1*0401, DRβ1*1401, DRβ1*1404, DRβ1*1501, DQβ1*0501, and DQα1*0201 showed statistically significant reduction in SLE patients, while these were much more common in controls, suggesting their protective role.
Conclusion:
This study is only the second study in patients from North India and it determines the role of DRβ1*0301, DRβ1*0701, DQβ1*0202, and DQβ1*0301 alleles as risk factors in SLE patients. |
| format | Article |
| id | doaj-art-9f25094ea4df418db3bc2a96c59eeb33 |
| institution | Kabale University |
| issn | 0377-4929 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-9f25094ea4df418db3bc2a96c59eeb332025-02-07T13:31:35ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292023-07-0166354554810.4103/ijpm.ijpm_764_21Role of HLA alleles polymorphism in systemic lupus erythematosus: A prospective study from North IndiaRanjan S. RanaBitan NaikMahima YadavUsha SinghAnup SinghShailja SinghBackground: Systemic lupus erythematosus (SLE) is a chronic autoimmune disorder and has complex etiopathogenesis. The most appropriate hypothesis states that genetic susceptibility in the presence of environmental risk factors predisposes to SLE. HLA class II alleles are critical to immune response and are highly polymorphic. Various alleles in HLA-DR and -DQ regions were analyzed in SLE patients and healthy controls to see their role in susceptibility or protection to SLE. Materials and Methods: This was a prospective observational study, in which a total of 100 SLE patients and 100 controls were analyzed. HLA typing was done by polymerase chain reaction (PCR)-sequence-specific oligonucleotide (SSO) method (SSO probe). Results: DRβ1*0301 was significantly increased in SLE patients when compared to controls and had the highest odds ratio. Other risk factor alleles found to be increased were DRβ1*0701, DQβ1*0202, and DQβ1*0301, which had a significant positive association with SLE, suggesting their role in susceptibility to SLE. In contrast, DRβ1*0401, DRβ1*1401, DRβ1*1404, DRβ1*1501, DQβ1*0501, and DQα1*0201 showed statistically significant reduction in SLE patients, while these were much more common in controls, suggesting their protective role. Conclusion: This study is only the second study in patients from North India and it determines the role of DRβ1*0301, DRβ1*0701, DQβ1*0202, and DQβ1*0301 alleles as risk factors in SLE patients.https://journals.lww.com/10.4103/ijpm.ijpm_764_21autoimmune diseasesdq alleles in autoimmune diseasesdr alleleshlasystemic lupus erythematosus |
| spellingShingle | Ranjan S. Rana Bitan Naik Mahima Yadav Usha Singh Anup Singh Shailja Singh Role of HLA alleles polymorphism in systemic lupus erythematosus: A prospective study from North India Indian Journal of Pathology and Microbiology autoimmune diseases dq alleles in autoimmune diseases dr alleles hla systemic lupus erythematosus |
| title | Role of HLA alleles polymorphism in systemic lupus erythematosus: A prospective study from North India |
| title_full | Role of HLA alleles polymorphism in systemic lupus erythematosus: A prospective study from North India |
| title_fullStr | Role of HLA alleles polymorphism in systemic lupus erythematosus: A prospective study from North India |
| title_full_unstemmed | Role of HLA alleles polymorphism in systemic lupus erythematosus: A prospective study from North India |
| title_short | Role of HLA alleles polymorphism in systemic lupus erythematosus: A prospective study from North India |
| title_sort | role of hla alleles polymorphism in systemic lupus erythematosus a prospective study from north india |
| topic | autoimmune diseases dq alleles in autoimmune diseases dr alleles hla systemic lupus erythematosus |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_764_21 |
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