Khat-induced conditioned place preference, extinction, and reinstatement in female mice
Khat (Catha edulis Forsk), the natural source of cathinone and other psychoactive agents, is chewed by millions of persons in eastern Africa and the Arabian Peninsula for its psychostimulant effect. Using the conditioned place preference paradigm, this study tested fresh khat extract for place prefe...
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| Language: | English |
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Elsevier
2025-06-01
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| Series: | IBRO Neuroscience Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667242124001088 |
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| author | Caroline K. Murithi Jacques M. Kabaru Nilesh B. Patel |
| author_facet | Caroline K. Murithi Jacques M. Kabaru Nilesh B. Patel |
| author_sort | Caroline K. Murithi |
| collection | DOAJ |
| description | Khat (Catha edulis Forsk), the natural source of cathinone and other psychoactive agents, is chewed by millions of persons in eastern Africa and the Arabian Peninsula for its psychostimulant effect. Using the conditioned place preference paradigm, this study tested fresh khat extract for place preference induction, extinction, and reinstatement. Female mice treated with 100 and 250 mg/kg of khat extract showed conditioned place preference, which was extinguished following a 16-day khat-free period. However, the place preference was reinstated following the first priming dose of the khat extract but not with the second priming dose done 35 days after the last conditioning treatment. The results show that khat has a rewarding/reinforcing property and can also lead to relapse behavior in persons attempting to stop khat use. |
| format | Article |
| id | doaj-art-9f24c2422fda4eea8a65b364c7b19588 |
| institution | Kabale University |
| issn | 2667-2421 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | IBRO Neuroscience Reports |
| spelling | doaj-art-9f24c2422fda4eea8a65b364c7b195882025-08-20T03:45:28ZengElsevierIBRO Neuroscience Reports2667-24212025-06-01181510.1016/j.ibneur.2024.11.015Khat-induced conditioned place preference, extinction, and reinstatement in female miceCaroline K. Murithi0Jacques M. Kabaru1Nilesh B. Patel2Department of Biology, Faculty of Sciences, University of Nairobi, P.O. Box 30197- 00100, Nairobi, Kenya; Corresponding author.Department of Biology, Faculty of Sciences, University of Nairobi, P.O. Box 30197- 00100, Nairobi, KenyaDepartment of Human Anatomy and Medical Physiology, Faculty of Health Sciences, University of Nairobi, P.O. Box 30197- 00100, Nairobi, KenyaKhat (Catha edulis Forsk), the natural source of cathinone and other psychoactive agents, is chewed by millions of persons in eastern Africa and the Arabian Peninsula for its psychostimulant effect. Using the conditioned place preference paradigm, this study tested fresh khat extract for place preference induction, extinction, and reinstatement. Female mice treated with 100 and 250 mg/kg of khat extract showed conditioned place preference, which was extinguished following a 16-day khat-free period. However, the place preference was reinstated following the first priming dose of the khat extract but not with the second priming dose done 35 days after the last conditioning treatment. The results show that khat has a rewarding/reinforcing property and can also lead to relapse behavior in persons attempting to stop khat use.http://www.sciencedirect.com/science/article/pii/S2667242124001088Catha edulisKhatConditioned place preferenceCathinoneExtinctionRelapse |
| spellingShingle | Caroline K. Murithi Jacques M. Kabaru Nilesh B. Patel Khat-induced conditioned place preference, extinction, and reinstatement in female mice IBRO Neuroscience Reports Catha edulis Khat Conditioned place preference Cathinone Extinction Relapse |
| title | Khat-induced conditioned place preference, extinction, and reinstatement in female mice |
| title_full | Khat-induced conditioned place preference, extinction, and reinstatement in female mice |
| title_fullStr | Khat-induced conditioned place preference, extinction, and reinstatement in female mice |
| title_full_unstemmed | Khat-induced conditioned place preference, extinction, and reinstatement in female mice |
| title_short | Khat-induced conditioned place preference, extinction, and reinstatement in female mice |
| title_sort | khat induced conditioned place preference extinction and reinstatement in female mice |
| topic | Catha edulis Khat Conditioned place preference Cathinone Extinction Relapse |
| url | http://www.sciencedirect.com/science/article/pii/S2667242124001088 |
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