Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy
Abstract Enriched environment (EE), as a non-pharmacological intervention, has garnered considerable attention for its potential to ameliorate neurodegenerative diseases (NDs). This review delineated the impact of EE on the biological functions associated with NDs, emphasizing its role in enhancing...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Clinical Epigenetics |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13148-025-01820-4 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585653371535360 |
|---|---|
| author | Yuan-qiao Xu Yanjiao Chen Jia-xin Xing Jun Yao |
| author_facet | Yuan-qiao Xu Yanjiao Chen Jia-xin Xing Jun Yao |
| author_sort | Yuan-qiao Xu |
| collection | DOAJ |
| description | Abstract Enriched environment (EE), as a non-pharmacological intervention, has garnered considerable attention for its potential to ameliorate neurodegenerative diseases (NDs). This review delineated the impact of EE on the biological functions associated with NDs, emphasizing its role in enhancing neural plasticity, reducing inflammation, and bolstering cognitive performance. We discussed the molecular underpinnings of the effects of EE, including modulation of key signaling pathways such as extracellular regulated kinase 1/2 (ERK1/2), mitogen-activated protein kinases (MAPK), and AMPK/SIRT1, which were implicated in neuroprotection and synaptic plasticity. Additionally, we scrutinized the influence of EE on epigenetic modifications and autophagy, processes pivotal to ND pathogenesis. Animal models, encompassing both rodents and larger animals, offer insights into the disease-modifying effects of EE, underscoring its potential as a complementary approach to pharmacological interventions. In summary, EE emerges as a promising strategy to augment cognitive function and decelerate the progression of NDs. |
| format | Article |
| id | doaj-art-9f1737eca5b941f6ba373cc921ad98c2 |
| institution | Kabale University |
| issn | 1868-7083 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Clinical Epigenetics |
| spelling | doaj-art-9f1737eca5b941f6ba373cc921ad98c22025-01-26T12:39:14ZengBMCClinical Epigenetics1868-70832025-01-0117112110.1186/s13148-025-01820-4Relationship between enriched environment and neurodegeneration: a review from mechanism to therapyYuan-qiao Xu0Yanjiao Chen1Jia-xin Xing2Jun Yao3School of Forensic Medicine, China Medical UniversityShanxi Provincial People’s HospitalSchool of Forensic Medicine, China Medical UniversitySchool of Forensic Medicine, China Medical UniversityAbstract Enriched environment (EE), as a non-pharmacological intervention, has garnered considerable attention for its potential to ameliorate neurodegenerative diseases (NDs). This review delineated the impact of EE on the biological functions associated with NDs, emphasizing its role in enhancing neural plasticity, reducing inflammation, and bolstering cognitive performance. We discussed the molecular underpinnings of the effects of EE, including modulation of key signaling pathways such as extracellular regulated kinase 1/2 (ERK1/2), mitogen-activated protein kinases (MAPK), and AMPK/SIRT1, which were implicated in neuroprotection and synaptic plasticity. Additionally, we scrutinized the influence of EE on epigenetic modifications and autophagy, processes pivotal to ND pathogenesis. Animal models, encompassing both rodents and larger animals, offer insights into the disease-modifying effects of EE, underscoring its potential as a complementary approach to pharmacological interventions. In summary, EE emerges as a promising strategy to augment cognitive function and decelerate the progression of NDs.https://doi.org/10.1186/s13148-025-01820-4Enriched environmentNeurodegenerationNeuroplasticityAnti-inflammatoryCognitive function |
| spellingShingle | Yuan-qiao Xu Yanjiao Chen Jia-xin Xing Jun Yao Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy Clinical Epigenetics Enriched environment Neurodegeneration Neuroplasticity Anti-inflammatory Cognitive function |
| title | Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy |
| title_full | Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy |
| title_fullStr | Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy |
| title_full_unstemmed | Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy |
| title_short | Relationship between enriched environment and neurodegeneration: a review from mechanism to therapy |
| title_sort | relationship between enriched environment and neurodegeneration a review from mechanism to therapy |
| topic | Enriched environment Neurodegeneration Neuroplasticity Anti-inflammatory Cognitive function |
| url | https://doi.org/10.1186/s13148-025-01820-4 |
| work_keys_str_mv | AT yuanqiaoxu relationshipbetweenenrichedenvironmentandneurodegenerationareviewfrommechanismtotherapy AT yanjiaochen relationshipbetweenenrichedenvironmentandneurodegenerationareviewfrommechanismtotherapy AT jiaxinxing relationshipbetweenenrichedenvironmentandneurodegenerationareviewfrommechanismtotherapy AT junyao relationshipbetweenenrichedenvironmentandneurodegenerationareviewfrommechanismtotherapy |