Microangiopathic Hemolytic Anemia: A Rare Complication of Acute Pancreatitis
Microangiopathic hemolytic anemia (MAHA) is a rare subtype of hemolytic anemia characterized by elevated hemolytic markers and red blood cell destruction. Though uncommon, MAHA can occur as a complication of acute pancreatitis because of the associated inflammatory response. Patients with MAHA secon...
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| Format: | Article |
| Language: | English |
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Jin Publishing & Printing Co.
2025-01-01
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| Series: | The Korean Journal of Gastroenterology |
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| Online Access: | https://www.kjg.or.kr/journal/view.html?uid=6082&vmd=Full |
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| author | Syedda Ayesha Masood Muhammad Karim Maria Ali Abdul Hadi Shahid Salman Naseem Adil |
| author_facet | Syedda Ayesha Masood Muhammad Karim Maria Ali Abdul Hadi Shahid Salman Naseem Adil |
| author_sort | Syedda Ayesha |
| collection | DOAJ |
| description | Microangiopathic hemolytic anemia (MAHA) is a rare subtype of hemolytic anemia characterized by elevated hemolytic markers and red blood cell destruction. Though uncommon, MAHA can occur as a complication of acute pancreatitis because of the associated inflammatory response. Patients with MAHA secondary to pancreatitis show favorable outcomes when treated with plasma exchange. This paper presents the case of a patient diagnosed with acute pancreatitis-induced hemolytic anemia and thrombocytopenia, who was managed successfully with plasma exchange, steroids, and rituximab. Clinicians should maintain a high index of suspicion in patients with acute pancreatitis who present with anemia, thrombocytopenia, and schistocytes on peripheral smears, even in the absence of end-organ injuries and with normal ADAMTS13 activity. The early initiation of plasmapheresis can be lifesaving. The timely introduction of rituximab in cases where plasma exchange and steroids are insufficient, despite the ADAMTS13 activity status, may lead to better outcomes. |
| format | Article |
| id | doaj-art-9f1227ad3790499fbacd747ef054fdcb |
| institution | Kabale University |
| issn | 1598-9992 2233-6869 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Jin Publishing & Printing Co. |
| record_format | Article |
| series | The Korean Journal of Gastroenterology |
| spelling | doaj-art-9f1227ad3790499fbacd747ef054fdcb2025-02-07T06:28:30ZengJin Publishing & Printing Co.The Korean Journal of Gastroenterology1598-99922233-68692025-01-01851737710.4166/kjg.2024.110Microangiopathic Hemolytic Anemia: A Rare Complication of Acute PancreatitisSyedda Ayesha0https://orcid.org/0009-0007-4893-3335Masood Muhammad Karim1Maria Ali2Abdul Hadi Shahid3Salman Naseem Adil4Section of Gastroenterology, Department of Medicine, Aga Khan University, PakistanSection of Gastroenterology, Department of Medicine, Aga Khan University, PakistanSection of Haematology, Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, PakistanMedical college, Aga Khan University, Karachi, PakistanSection of Haematology, Department of Pathology and Laboratory Medicine, Aga Khan University, Karachi, PakistanMicroangiopathic hemolytic anemia (MAHA) is a rare subtype of hemolytic anemia characterized by elevated hemolytic markers and red blood cell destruction. Though uncommon, MAHA can occur as a complication of acute pancreatitis because of the associated inflammatory response. Patients with MAHA secondary to pancreatitis show favorable outcomes when treated with plasma exchange. This paper presents the case of a patient diagnosed with acute pancreatitis-induced hemolytic anemia and thrombocytopenia, who was managed successfully with plasma exchange, steroids, and rituximab. Clinicians should maintain a high index of suspicion in patients with acute pancreatitis who present with anemia, thrombocytopenia, and schistocytes on peripheral smears, even in the absence of end-organ injuries and with normal ADAMTS13 activity. The early initiation of plasmapheresis can be lifesaving. The timely introduction of rituximab in cases where plasma exchange and steroids are insufficient, despite the ADAMTS13 activity status, may lead to better outcomes.https://www.kjg.or.kr/journal/view.html?uid=6082&vmd=Fullpancreatitismicroangiopathic hemolytic anemiathrombocytopeniaplasmapheresisrituximab |
| spellingShingle | Syedda Ayesha Masood Muhammad Karim Maria Ali Abdul Hadi Shahid Salman Naseem Adil Microangiopathic Hemolytic Anemia: A Rare Complication of Acute Pancreatitis The Korean Journal of Gastroenterology pancreatitis microangiopathic hemolytic anemia thrombocytopenia plasmapheresis rituximab |
| title | Microangiopathic Hemolytic Anemia: A Rare Complication of Acute Pancreatitis |
| title_full | Microangiopathic Hemolytic Anemia: A Rare Complication of Acute Pancreatitis |
| title_fullStr | Microangiopathic Hemolytic Anemia: A Rare Complication of Acute Pancreatitis |
| title_full_unstemmed | Microangiopathic Hemolytic Anemia: A Rare Complication of Acute Pancreatitis |
| title_short | Microangiopathic Hemolytic Anemia: A Rare Complication of Acute Pancreatitis |
| title_sort | microangiopathic hemolytic anemia a rare complication of acute pancreatitis |
| topic | pancreatitis microangiopathic hemolytic anemia thrombocytopenia plasmapheresis rituximab |
| url | https://www.kjg.or.kr/journal/view.html?uid=6082&vmd=Full |
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