Efficacy of injectable platelet-rich fibrin (i-PRF) as a novel vehicle for local drug delivery in non-surgical periodontal pocket therapy: A randomized controlled clinical trial
Background. The vehicle in a local drug delivery (LDD) system plays a vital role in delivering the active drug component at the diseased site. Liquid/injectable platelet-rich fibrin (i-PRF), an autologous fibrin matrix, might be used as a vehicle to enmesh drugs and deliver locally at the periodonta...
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| Language: | English |
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Tabriz University of Medical Sciences
2024-11-01
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| Series: | Journal of Advanced Periodontology and Implant Dentistry |
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| Online Access: | https://japid.tbzmed.ac.ir/PDF/japid-16-94.pdf |
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| author | Murugan Thamaraiselvan Nadathur Doraisamy Jayakumar |
| author_facet | Murugan Thamaraiselvan Nadathur Doraisamy Jayakumar |
| author_sort | Murugan Thamaraiselvan |
| collection | DOAJ |
| description | Background. The vehicle in a local drug delivery (LDD) system plays a vital role in delivering the active drug component at the diseased site. Liquid/injectable platelet-rich fibrin (i-PRF), an autologous fibrin matrix, might be used as a vehicle to enmesh drugs and deliver locally at the periodontally diseased sites. This study evaluated the efficacy of the drug (ciprofloxacin [Cip])-loaded i-PRF as a LDD system adjunct to subgingival debridement in subjects with periodontal pockets. Methods. In a parallel design study, 79 periodontally diseased pocket sites were randomized to 3 groups: group 1 (n=25), scaling and root planing (SRP)+i-PRF+Cip; group 2 (n=25), SRP+i-PRF; group 3 (n=25), SRP without any adjunctive intervention. Clinical parameters (probing depth [PD], clinical attachment level [CAL], gingival index [GI], plaque index [PI]) and microbial quantification (relative quantification of levels of Aggregatibacter actinomycetemcomitans) were assessed from baseline to 6th and 12th weeks of follow-up. Results. All the treatment groups showed significant improvements in the clinical and microbial parameters assessed. Group 1 showed significantly higher PD and GI reduction with CAL gain and decreased in relative levels of A. actinomycetemcomitans in the 12th week, followed by group 2 compared to group 3. Conclusion. Thus, within the limits of this study, it can be concluded that i-PRF could be considered a potential LDD vehicle for the delivery of ciprofloxacin in periodontal pocket therapy. |
| format | Article |
| id | doaj-art-9f0cf403d2c643f1addaf568cf5950f6 |
| institution | DOAJ |
| issn | 2645-5390 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Journal of Advanced Periodontology and Implant Dentistry |
| spelling | doaj-art-9f0cf403d2c643f1addaf568cf5950f62025-08-20T03:06:35ZengTabriz University of Medical SciencesJournal of Advanced Periodontology and Implant Dentistry2645-53902024-11-011629410210.34172/japid.2024.021japid-3522Efficacy of injectable platelet-rich fibrin (i-PRF) as a novel vehicle for local drug delivery in non-surgical periodontal pocket therapy: A randomized controlled clinical trialMurugan Thamaraiselvan0Nadathur Doraisamy Jayakumar1Department of Periodontics, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamilnadu, IndiaDepartment of Periodontics, Saveetha Dental College & Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai, Tamilnadu, IndiaBackground. The vehicle in a local drug delivery (LDD) system plays a vital role in delivering the active drug component at the diseased site. Liquid/injectable platelet-rich fibrin (i-PRF), an autologous fibrin matrix, might be used as a vehicle to enmesh drugs and deliver locally at the periodontally diseased sites. This study evaluated the efficacy of the drug (ciprofloxacin [Cip])-loaded i-PRF as a LDD system adjunct to subgingival debridement in subjects with periodontal pockets. Methods. In a parallel design study, 79 periodontally diseased pocket sites were randomized to 3 groups: group 1 (n=25), scaling and root planing (SRP)+i-PRF+Cip; group 2 (n=25), SRP+i-PRF; group 3 (n=25), SRP without any adjunctive intervention. Clinical parameters (probing depth [PD], clinical attachment level [CAL], gingival index [GI], plaque index [PI]) and microbial quantification (relative quantification of levels of Aggregatibacter actinomycetemcomitans) were assessed from baseline to 6th and 12th weeks of follow-up. Results. All the treatment groups showed significant improvements in the clinical and microbial parameters assessed. Group 1 showed significantly higher PD and GI reduction with CAL gain and decreased in relative levels of A. actinomycetemcomitans in the 12th week, followed by group 2 compared to group 3. Conclusion. Thus, within the limits of this study, it can be concluded that i-PRF could be considered a potential LDD vehicle for the delivery of ciprofloxacin in periodontal pocket therapy.https://japid.tbzmed.ac.ir/PDF/japid-16-94.pdfdrug carriersplatelet-rich fibrinperiodontal disease |
| spellingShingle | Murugan Thamaraiselvan Nadathur Doraisamy Jayakumar Efficacy of injectable platelet-rich fibrin (i-PRF) as a novel vehicle for local drug delivery in non-surgical periodontal pocket therapy: A randomized controlled clinical trial Journal of Advanced Periodontology and Implant Dentistry drug carriers platelet-rich fibrin periodontal disease |
| title | Efficacy of injectable platelet-rich fibrin (i-PRF) as a novel vehicle for local drug delivery in non-surgical periodontal pocket therapy: A randomized controlled clinical trial |
| title_full | Efficacy of injectable platelet-rich fibrin (i-PRF) as a novel vehicle for local drug delivery in non-surgical periodontal pocket therapy: A randomized controlled clinical trial |
| title_fullStr | Efficacy of injectable platelet-rich fibrin (i-PRF) as a novel vehicle for local drug delivery in non-surgical periodontal pocket therapy: A randomized controlled clinical trial |
| title_full_unstemmed | Efficacy of injectable platelet-rich fibrin (i-PRF) as a novel vehicle for local drug delivery in non-surgical periodontal pocket therapy: A randomized controlled clinical trial |
| title_short | Efficacy of injectable platelet-rich fibrin (i-PRF) as a novel vehicle for local drug delivery in non-surgical periodontal pocket therapy: A randomized controlled clinical trial |
| title_sort | efficacy of injectable platelet rich fibrin i prf as a novel vehicle for local drug delivery in non surgical periodontal pocket therapy a randomized controlled clinical trial |
| topic | drug carriers platelet-rich fibrin periodontal disease |
| url | https://japid.tbzmed.ac.ir/PDF/japid-16-94.pdf |
| work_keys_str_mv | AT muruganthamaraiselvan efficacyofinjectableplateletrichfibriniprfasanovelvehicleforlocaldrugdeliveryinnonsurgicalperiodontalpockettherapyarandomizedcontrolledclinicaltrial AT nadathurdoraisamyjayakumar efficacyofinjectableplateletrichfibriniprfasanovelvehicleforlocaldrugdeliveryinnonsurgicalperiodontalpockettherapyarandomizedcontrolledclinicaltrial |