Crystallization test: A prognostic biomarker in oral potentially malignant disorders and oral cancer
Aim: The aim of study is to evaluate the crystallization pattern seen in cupric chloride medium using haemolyzed blood of control, Oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) patients. Materials and Methods: Study comprise 90 patients including control, OPMDs...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-12-01
|
| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/ijpm.ijpm_959_23 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1841550023214497792 |
|---|---|
| author | Kinjal Joshi Jigna Shah |
| author_facet | Kinjal Joshi Jigna Shah |
| author_sort | Kinjal Joshi |
| collection | DOAJ |
| description | Aim:
The aim of study is to evaluate the crystallization pattern seen in cupric chloride medium using haemolyzed blood of control, Oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) patients.
Materials and Methods:
Study comprise 90 patients including control, OPMDs and OSCC. To create a haemolysed blood, a drop of blood was obtained and distilled water was added. Crystallization test using 0.1 ml of haemolyzed blood and 20% of a 10 ml cupric chloride solution. During 24 to 28 hours, this solution was put in a BOD incubator.
Result:
Crystallization pattern in control group is eccentric placed nucleus and peripheral radiating lines while in OPMDs and OSCC presence of transverse bar. Crystallization test showed 100% positivity in OSCC while 73.33% seen in control group. 90% sensitivity in OSCC and 76.67% sensitivity in OPMDs.
Conclusion:
OPMDs lesion convert from white to mixed red and white lesion and OSCC appear as non-healing ulcer or ulcero-proliferative growth increase in number of transverse bars. More number of transverse bars suggestive of high malignant potential. |
| format | Article |
| id | doaj-art-9f09f6a8838f47e3893a2d491a808bec |
| institution | Kabale University |
| issn | 0377-4929 0974-5130 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj-art-9f09f6a8838f47e3893a2d491a808bec2025-01-10T10:24:49ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49290974-51302024-12-0167482983410.4103/ijpm.ijpm_959_23Crystallization test: A prognostic biomarker in oral potentially malignant disorders and oral cancerKinjal JoshiJigna ShahAim: The aim of study is to evaluate the crystallization pattern seen in cupric chloride medium using haemolyzed blood of control, Oral potentially malignant disorders (OPMDs) and oral squamous cell carcinoma (OSCC) patients. Materials and Methods: Study comprise 90 patients including control, OPMDs and OSCC. To create a haemolysed blood, a drop of blood was obtained and distilled water was added. Crystallization test using 0.1 ml of haemolyzed blood and 20% of a 10 ml cupric chloride solution. During 24 to 28 hours, this solution was put in a BOD incubator. Result: Crystallization pattern in control group is eccentric placed nucleus and peripheral radiating lines while in OPMDs and OSCC presence of transverse bar. Crystallization test showed 100% positivity in OSCC while 73.33% seen in control group. 90% sensitivity in OSCC and 76.67% sensitivity in OPMDs. Conclusion: OPMDs lesion convert from white to mixed red and white lesion and OSCC appear as non-healing ulcer or ulcero-proliferative growth increase in number of transverse bars. More number of transverse bars suggestive of high malignant potential.https://journals.lww.com/10.4103/ijpm.ijpm_959_23crystallization testoral potentially malignant disordersoral squamous cell carcinomatransverse bar |
| spellingShingle | Kinjal Joshi Jigna Shah Crystallization test: A prognostic biomarker in oral potentially malignant disorders and oral cancer Indian Journal of Pathology and Microbiology crystallization test oral potentially malignant disorders oral squamous cell carcinoma transverse bar |
| title | Crystallization test: A prognostic biomarker in oral potentially malignant disorders and oral cancer |
| title_full | Crystallization test: A prognostic biomarker in oral potentially malignant disorders and oral cancer |
| title_fullStr | Crystallization test: A prognostic biomarker in oral potentially malignant disorders and oral cancer |
| title_full_unstemmed | Crystallization test: A prognostic biomarker in oral potentially malignant disorders and oral cancer |
| title_short | Crystallization test: A prognostic biomarker in oral potentially malignant disorders and oral cancer |
| title_sort | crystallization test a prognostic biomarker in oral potentially malignant disorders and oral cancer |
| topic | crystallization test oral potentially malignant disorders oral squamous cell carcinoma transverse bar |
| url | https://journals.lww.com/10.4103/ijpm.ijpm_959_23 |
| work_keys_str_mv | AT kinjaljoshi crystallizationtestaprognosticbiomarkerinoralpotentiallymalignantdisordersandoralcancer AT jignashah crystallizationtestaprognosticbiomarkerinoralpotentiallymalignantdisordersandoralcancer |