Overview of the Association Between Non-Alcoholic Fatty Liver Disease and Hypertension
Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and its prevalence is rising. NAFLD is closely associated with metabolic syndrome, with both conditions sharing common clinical characteristics such as obesity, insulin resistance, type 2 diabetes mellitus, hypertens...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Health/LWW
2024-03-01
|
| Series: | Cardiology Discovery |
| Online Access: | http://journals.lww.com/10.1097/CD9.0000000000000113 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850265795298328576 |
|---|---|
| author | Niki S. Kakouri Costas G. Thomopoulos Eirini P. Siafi Angeliki E. Valatsou Kyriakos S. Dimitriadis Iliana P. Mani Sotirios P. Patsilinakos Dimitrios M. Tousoulis Konstantinos P. Tsioufis |
| author_facet | Niki S. Kakouri Costas G. Thomopoulos Eirini P. Siafi Angeliki E. Valatsou Kyriakos S. Dimitriadis Iliana P. Mani Sotirios P. Patsilinakos Dimitrios M. Tousoulis Konstantinos P. Tsioufis |
| author_sort | Niki S. Kakouri |
| collection | DOAJ |
| description | Non-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and its prevalence is rising. NAFLD is closely associated with metabolic syndrome, with both conditions sharing common clinical characteristics such as obesity, insulin resistance, type 2 diabetes mellitus, hypertension, and hypertriglyceridemia. Several observational studies have evaluated the relationship between NAFLD and hypertension, with the overall evidence suggesting a bidirectional relationship. It is hypothesized that activation of the sympathetic nervous and renin-angiotensin systems, observed in NAFLD with or without insulin resistance promotes the development of hypertension. In patients with hypertension, activation of these systems can lead to hepatic fibrosis and progressive inflammation through increased oxidative stress and activation of hepatic stellate cells and Kupffer cells. The present review examines the pathophysiologic and clinical evidence supporting the bidirectional association between NAFLD and hypertension. |
| format | Article |
| id | doaj-art-9f07b29e4ab14cd5a78f62ed1b21ff80 |
| institution | OA Journals |
| issn | 2096-952X 2693-8499 |
| language | English |
| publishDate | 2024-03-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Cardiology Discovery |
| spelling | doaj-art-9f07b29e4ab14cd5a78f62ed1b21ff802025-08-20T01:54:19ZengWolters Kluwer Health/LWWCardiology Discovery2096-952X2693-84992024-03-0141303710.1097/CD9.0000000000000113202403000-00005Overview of the Association Between Non-Alcoholic Fatty Liver Disease and HypertensionNiki S. Kakouri0Costas G. Thomopoulos1Eirini P. Siafi2Angeliki E. Valatsou3Kyriakos S. Dimitriadis4Iliana P. Mani5Sotirios P. Patsilinakos6Dimitrios M. Tousoulis7Konstantinos P. Tsioufis81 First Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens 11527, Greece2 Department of Cardiology, Elena Venizelou Hospital, Athens 11521, Greece1 First Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens 11527, Greece1 First Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens 11527, Greece1 First Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens 11527, Greece1 First Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens 11527, Greece3 Department of Cardiology, General Hospital Agia Olga, Athens 14233, Greece.1 First Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens 11527, Greece1 First Department of Cardiology, Medical School, National and Kapodistrian University of Athens, Hippokration Hospital, Athens 11527, GreeceNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease, and its prevalence is rising. NAFLD is closely associated with metabolic syndrome, with both conditions sharing common clinical characteristics such as obesity, insulin resistance, type 2 diabetes mellitus, hypertension, and hypertriglyceridemia. Several observational studies have evaluated the relationship between NAFLD and hypertension, with the overall evidence suggesting a bidirectional relationship. It is hypothesized that activation of the sympathetic nervous and renin-angiotensin systems, observed in NAFLD with or without insulin resistance promotes the development of hypertension. In patients with hypertension, activation of these systems can lead to hepatic fibrosis and progressive inflammation through increased oxidative stress and activation of hepatic stellate cells and Kupffer cells. The present review examines the pathophysiologic and clinical evidence supporting the bidirectional association between NAFLD and hypertension.http://journals.lww.com/10.1097/CD9.0000000000000113 |
| spellingShingle | Niki S. Kakouri Costas G. Thomopoulos Eirini P. Siafi Angeliki E. Valatsou Kyriakos S. Dimitriadis Iliana P. Mani Sotirios P. Patsilinakos Dimitrios M. Tousoulis Konstantinos P. Tsioufis Overview of the Association Between Non-Alcoholic Fatty Liver Disease and Hypertension Cardiology Discovery |
| title | Overview of the Association Between Non-Alcoholic Fatty Liver Disease and Hypertension |
| title_full | Overview of the Association Between Non-Alcoholic Fatty Liver Disease and Hypertension |
| title_fullStr | Overview of the Association Between Non-Alcoholic Fatty Liver Disease and Hypertension |
| title_full_unstemmed | Overview of the Association Between Non-Alcoholic Fatty Liver Disease and Hypertension |
| title_short | Overview of the Association Between Non-Alcoholic Fatty Liver Disease and Hypertension |
| title_sort | overview of the association between non alcoholic fatty liver disease and hypertension |
| url | http://journals.lww.com/10.1097/CD9.0000000000000113 |
| work_keys_str_mv | AT nikiskakouri overviewoftheassociationbetweennonalcoholicfattyliverdiseaseandhypertension AT costasgthomopoulos overviewoftheassociationbetweennonalcoholicfattyliverdiseaseandhypertension AT eirinipsiafi overviewoftheassociationbetweennonalcoholicfattyliverdiseaseandhypertension AT angelikievalatsou overviewoftheassociationbetweennonalcoholicfattyliverdiseaseandhypertension AT kyriakossdimitriadis overviewoftheassociationbetweennonalcoholicfattyliverdiseaseandhypertension AT ilianapmani overviewoftheassociationbetweennonalcoholicfattyliverdiseaseandhypertension AT sotiriosppatsilinakos overviewoftheassociationbetweennonalcoholicfattyliverdiseaseandhypertension AT dimitriosmtousoulis overviewoftheassociationbetweennonalcoholicfattyliverdiseaseandhypertension AT konstantinosptsioufis overviewoftheassociationbetweennonalcoholicfattyliverdiseaseandhypertension |