Unveiling BPS-induced colonic inflammatory injury in female mice: Integrated evidence from colon microbiome and metabolomic analyses
Bisphenol S (BPS), a common alternative to bisphenol A (BPA), is extensively utilized in the production of food-contact materials. Concerns about its potential health impacts have grown. However, the effects of BPS exposure on colonic physiology and its underlying molecular mechanisms remain poorly...
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Elsevier
2025-09-01
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| Series: | Ecotoxicology and Environmental Safety |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651325010929 |
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| author | Han Liu Yutian Wang Lisi Wei Jing Xu Ruirui Wang Ling-Guo Zhao Zhi Tang |
| author_facet | Han Liu Yutian Wang Lisi Wei Jing Xu Ruirui Wang Ling-Guo Zhao Zhi Tang |
| author_sort | Han Liu |
| collection | DOAJ |
| description | Bisphenol S (BPS), a common alternative to bisphenol A (BPA), is extensively utilized in the production of food-contact materials. Concerns about its potential health impacts have grown. However, the effects of BPS exposure on colonic physiology and its underlying molecular mechanisms remain poorly characterized. This study aimed to elucidate the effects of BPS exposure on gut health in female mice, focusing on investigate the role of colon microbiome and metabolome involved in these effects. The effects of BPS exposure on female mice were evaluated via oral gavage administration at doses of 0.05 mg/kg/day and 5 mg/kg/day for four weeks. Fecal samples and colon tissue collected from BPS exposure and control group were subjected to 16S rRNA gene sequencing and GC-MS based metabolomic analysis. Our results show that BPS exposure caused typical colonic damage, including shortened colon length, inflammatory responses, and weakened gut barrier function. Significant alterations were observed in gut microbiota composition, showing imbalances between harmful and beneficial bacteria, with a significant decrease in genera such as Paraprevotella, Ruminococcaceae NK4A214 group, Ruminiclostridium 6, and an increase in Escherichia, Helicobacter, Parasutterella, Erysipelatoclostridium, and Achromobacter. Moreover, metabolic pathways associated with colonic inflammation, including tryptophan metabolism, glutamate metabolism, and fatty acid metabolism, were significantly altered. Our findings demonstrate that BPS exposure compromises colonic homeostasis, induces dysbiosis of the gut microbiota, and disrupts colonic metabolic activity. These findings may provide critical molecular insights regarding disruption of gut integrity as a potential new pathway for mitigating human health risks associated with bisphenol S exposure. |
| format | Article |
| id | doaj-art-9f04d06bcba540c6a45ee44b781543b7 |
| institution | DOAJ |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-9f04d06bcba540c6a45ee44b781543b72025-08-20T03:05:34ZengElsevierEcotoxicology and Environmental Safety0147-65132025-09-0130211874710.1016/j.ecoenv.2025.118747Unveiling BPS-induced colonic inflammatory injury in female mice: Integrated evidence from colon microbiome and metabolomic analysesHan Liu0Yutian Wang1Lisi Wei2Jing Xu3Ruirui Wang4Ling-Guo Zhao5Zhi Tang6Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, ChinaDongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, ChinaDongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, ChinaDongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, ChinaDongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, ChinaCenter for Disease Prevention and Control of Baoan District, Shenzhen, Guangdong Province 518101, China; Corresponding authors.Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Dongguan 523808, China; Corresponding authors.Bisphenol S (BPS), a common alternative to bisphenol A (BPA), is extensively utilized in the production of food-contact materials. Concerns about its potential health impacts have grown. However, the effects of BPS exposure on colonic physiology and its underlying molecular mechanisms remain poorly characterized. This study aimed to elucidate the effects of BPS exposure on gut health in female mice, focusing on investigate the role of colon microbiome and metabolome involved in these effects. The effects of BPS exposure on female mice were evaluated via oral gavage administration at doses of 0.05 mg/kg/day and 5 mg/kg/day for four weeks. Fecal samples and colon tissue collected from BPS exposure and control group were subjected to 16S rRNA gene sequencing and GC-MS based metabolomic analysis. Our results show that BPS exposure caused typical colonic damage, including shortened colon length, inflammatory responses, and weakened gut barrier function. Significant alterations were observed in gut microbiota composition, showing imbalances between harmful and beneficial bacteria, with a significant decrease in genera such as Paraprevotella, Ruminococcaceae NK4A214 group, Ruminiclostridium 6, and an increase in Escherichia, Helicobacter, Parasutterella, Erysipelatoclostridium, and Achromobacter. Moreover, metabolic pathways associated with colonic inflammation, including tryptophan metabolism, glutamate metabolism, and fatty acid metabolism, were significantly altered. Our findings demonstrate that BPS exposure compromises colonic homeostasis, induces dysbiosis of the gut microbiota, and disrupts colonic metabolic activity. These findings may provide critical molecular insights regarding disruption of gut integrity as a potential new pathway for mitigating human health risks associated with bisphenol S exposure.http://www.sciencedirect.com/science/article/pii/S0147651325010929Bisphenol SColonic injuryGut barrier functionMicrobiomeTryptophan metabolism |
| spellingShingle | Han Liu Yutian Wang Lisi Wei Jing Xu Ruirui Wang Ling-Guo Zhao Zhi Tang Unveiling BPS-induced colonic inflammatory injury in female mice: Integrated evidence from colon microbiome and metabolomic analyses Ecotoxicology and Environmental Safety Bisphenol S Colonic injury Gut barrier function Microbiome Tryptophan metabolism |
| title | Unveiling BPS-induced colonic inflammatory injury in female mice: Integrated evidence from colon microbiome and metabolomic analyses |
| title_full | Unveiling BPS-induced colonic inflammatory injury in female mice: Integrated evidence from colon microbiome and metabolomic analyses |
| title_fullStr | Unveiling BPS-induced colonic inflammatory injury in female mice: Integrated evidence from colon microbiome and metabolomic analyses |
| title_full_unstemmed | Unveiling BPS-induced colonic inflammatory injury in female mice: Integrated evidence from colon microbiome and metabolomic analyses |
| title_short | Unveiling BPS-induced colonic inflammatory injury in female mice: Integrated evidence from colon microbiome and metabolomic analyses |
| title_sort | unveiling bps induced colonic inflammatory injury in female mice integrated evidence from colon microbiome and metabolomic analyses |
| topic | Bisphenol S Colonic injury Gut barrier function Microbiome Tryptophan metabolism |
| url | http://www.sciencedirect.com/science/article/pii/S0147651325010929 |
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