Prospective Trial of a Novel Nomogram to Achieve Updated Vancomycin Trough Concentrations
Purpose. To determine if the use of a novel vancomycin nomogram predicts dosing regimens that achieve target trough concentrations equal to or more accurate than dosing regimens calculated using traditional pharmacokinetic calculations, evaluate the incidence of subtherapeutic and supratherapeutic t...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2013-01-01
|
| Series: | Interdisciplinary Perspectives on Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2013/839456 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832549247704104960 |
|---|---|
| author | Amber R. Wesner Marcia L. Brackbill Larissa L. Coyle Robert S. Kidd |
| author_facet | Amber R. Wesner Marcia L. Brackbill Larissa L. Coyle Robert S. Kidd |
| author_sort | Amber R. Wesner |
| collection | DOAJ |
| description | Purpose. To determine if the use of a novel vancomycin nomogram predicts dosing regimens that achieve target trough concentrations equal to or more accurate than dosing regimens calculated using traditional pharmacokinetic calculations, evaluate the incidence of subtherapeutic and supratherapeutic troughs, and assess pharmacist's impressions of the nomogram.
Methods. Prospective, open-label study in 473 patients who had a new order for vancomycin and were >18 years of age and ≤120 kg. Patients were randomized to the active group, dosed using the nomogram, or to the control group, dosed using traditional pharmacokinetic calculations already in place at our institution.
Results. Patients dosed via nomogram were within the appropriate trough range in 44% of cases compared to 33% in the control group (P=0.014). Vancomycin troughs less than 10 mcg/mL were significantly decreased with the use of nomogram (P=0.032). Incidence of supratherapeutic troughs, greater than 20 mcg/mL, was not significantly different between groups (P=0.706), and pharmacists agreed that the nomogram was easy to use and saved their time.
Conclusions. A novel vancomycin nomogram was prospectively validated and found to be more effective than traditional pharmacokinetic dosing. The nomogram is being implemented as the standard dosing protocol at our institution. |
| format | Article |
| id | doaj-art-9f032cac19194b549d8d0763d060917d |
| institution | Kabale University |
| issn | 1687-708X 1687-7098 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Interdisciplinary Perspectives on Infectious Diseases |
| spelling | doaj-art-9f032cac19194b549d8d0763d060917d2025-02-03T06:11:42ZengWileyInterdisciplinary Perspectives on Infectious Diseases1687-708X1687-70982013-01-01201310.1155/2013/839456839456Prospective Trial of a Novel Nomogram to Achieve Updated Vancomycin Trough ConcentrationsAmber R. Wesner0Marcia L. Brackbill1Larissa L. Coyle2Robert S. Kidd3Department of Pharmacy Practice, Shenandoah University, 1775 North Sector Court, Winchester, VA 22601, USADepartment of Pharmacy Practice, Shenandoah University, 1775 North Sector Court, Winchester, VA 22601, USADepartment of Pharmacy, Winchester Medical Center, 1840 Amherst Street, Winchester, VA 22601, USADepartment of Biopharmaceutical Sciences, Shenandoah University, 1775 North Sector Court, Winchester, VA 22601, USAPurpose. To determine if the use of a novel vancomycin nomogram predicts dosing regimens that achieve target trough concentrations equal to or more accurate than dosing regimens calculated using traditional pharmacokinetic calculations, evaluate the incidence of subtherapeutic and supratherapeutic troughs, and assess pharmacist's impressions of the nomogram. Methods. Prospective, open-label study in 473 patients who had a new order for vancomycin and were >18 years of age and ≤120 kg. Patients were randomized to the active group, dosed using the nomogram, or to the control group, dosed using traditional pharmacokinetic calculations already in place at our institution. Results. Patients dosed via nomogram were within the appropriate trough range in 44% of cases compared to 33% in the control group (P=0.014). Vancomycin troughs less than 10 mcg/mL were significantly decreased with the use of nomogram (P=0.032). Incidence of supratherapeutic troughs, greater than 20 mcg/mL, was not significantly different between groups (P=0.706), and pharmacists agreed that the nomogram was easy to use and saved their time. Conclusions. A novel vancomycin nomogram was prospectively validated and found to be more effective than traditional pharmacokinetic dosing. The nomogram is being implemented as the standard dosing protocol at our institution.http://dx.doi.org/10.1155/2013/839456 |
| spellingShingle | Amber R. Wesner Marcia L. Brackbill Larissa L. Coyle Robert S. Kidd Prospective Trial of a Novel Nomogram to Achieve Updated Vancomycin Trough Concentrations Interdisciplinary Perspectives on Infectious Diseases |
| title | Prospective Trial of a Novel Nomogram to Achieve Updated Vancomycin Trough Concentrations |
| title_full | Prospective Trial of a Novel Nomogram to Achieve Updated Vancomycin Trough Concentrations |
| title_fullStr | Prospective Trial of a Novel Nomogram to Achieve Updated Vancomycin Trough Concentrations |
| title_full_unstemmed | Prospective Trial of a Novel Nomogram to Achieve Updated Vancomycin Trough Concentrations |
| title_short | Prospective Trial of a Novel Nomogram to Achieve Updated Vancomycin Trough Concentrations |
| title_sort | prospective trial of a novel nomogram to achieve updated vancomycin trough concentrations |
| url | http://dx.doi.org/10.1155/2013/839456 |
| work_keys_str_mv | AT amberrwesner prospectivetrialofanovelnomogramtoachieveupdatedvancomycintroughconcentrations AT marcialbrackbill prospectivetrialofanovelnomogramtoachieveupdatedvancomycintroughconcentrations AT larissalcoyle prospectivetrialofanovelnomogramtoachieveupdatedvancomycintroughconcentrations AT robertskidd prospectivetrialofanovelnomogramtoachieveupdatedvancomycintroughconcentrations |