Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer
Background and Purpose. The mevalonate pathway is one of the major metabolic pathways that use acetyl-CoA to produce sterols and isoprenoids. These compounds can be effective in the growth and development of tumors. One of the enzymes involved in the mevalonate pathway is FDFT1. Different variants o...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2018-01-01
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| Series: | International Journal of Genomics |
| Online Access: | http://dx.doi.org/10.1155/2018/4863757 |
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| author | Mehdi Dehghani Zahra Samani Hassan Abidi Leila Manzouri Reza Mahmoudi Saeed Hosseini Teshnizi Mohsen Nikseresht |
| author_facet | Mehdi Dehghani Zahra Samani Hassan Abidi Leila Manzouri Reza Mahmoudi Saeed Hosseini Teshnizi Mohsen Nikseresht |
| author_sort | Mehdi Dehghani |
| collection | DOAJ |
| description | Background and Purpose. The mevalonate pathway is one of the major metabolic pathways that use acetyl-CoA to produce sterols and isoprenoids. These compounds can be effective in the growth and development of tumors. One of the enzymes involved in the mevalonate pathway is FDFT1. Different variants of this gene are involved in the risk of suffering various diseases. The present study examined the relationship between FDFT1 rs2645429 polymorphism and the risk of nonsmall cell lung cancer (NSCLC) in a population from southern Iran. Method. The genotypes of rs2645429 polymorphism of FDFT1 gene were examined in 95 samples: 34 patients with NSCLC and 61 healthy individuals by RFLP method. Results. The results of this study indicated that C allele of this polymorphism was effectively associated with the risk of NSCLC in the Iranian population (p value = 0.023; OR = 2.71; 95% CI = 1.12–6.59) and CC genotype has significant relation with susceptibility to NSCLC (p value = 0.029; OR = 3.02; 95% CI = 1.09–8.39). This polymorphism is located in the promoter region FDFT1 gene, and CC genotype may increase the activity of this promoter. This study also found a significant relationship between C allele and metastatic status. C allele was more common in NSCLC patients. (p=0.04). Conclusion. C allele of FDFT1 rs2645429 polymorphism gene can be a risk factor for NSCLC, whereas T allele probably has a low protective role. |
| format | Article |
| id | doaj-art-9f00d57d60e24000913875afe976a2fa |
| institution | Kabale University |
| issn | 2314-436X 2314-4378 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Genomics |
| spelling | doaj-art-9f00d57d60e24000913875afe976a2fa2025-08-20T03:38:30ZengWileyInternational Journal of Genomics2314-436X2314-43782018-01-01201810.1155/2018/48637574863757Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung CancerMehdi Dehghani0Zahra Samani1Hassan Abidi2Leila Manzouri3Reza Mahmoudi4Saeed Hosseini Teshnizi5Mohsen Nikseresht6Hematology and Medical Oncology Department, Hematology Research Center, Shiraz University of Medical Sciences, Shiraz, IranCellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, IranCellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, IranSocial Determinant of Health Research Center, Yasuj University of Medical Sciences, Yasuj, IranCellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, IranBiostatistican, Molecular Medicine Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, IranCellular and Molecular Research Center, Yasuj University of Medical Sciences, Yasuj, IranBackground and Purpose. The mevalonate pathway is one of the major metabolic pathways that use acetyl-CoA to produce sterols and isoprenoids. These compounds can be effective in the growth and development of tumors. One of the enzymes involved in the mevalonate pathway is FDFT1. Different variants of this gene are involved in the risk of suffering various diseases. The present study examined the relationship between FDFT1 rs2645429 polymorphism and the risk of nonsmall cell lung cancer (NSCLC) in a population from southern Iran. Method. The genotypes of rs2645429 polymorphism of FDFT1 gene were examined in 95 samples: 34 patients with NSCLC and 61 healthy individuals by RFLP method. Results. The results of this study indicated that C allele of this polymorphism was effectively associated with the risk of NSCLC in the Iranian population (p value = 0.023; OR = 2.71; 95% CI = 1.12–6.59) and CC genotype has significant relation with susceptibility to NSCLC (p value = 0.029; OR = 3.02; 95% CI = 1.09–8.39). This polymorphism is located in the promoter region FDFT1 gene, and CC genotype may increase the activity of this promoter. This study also found a significant relationship between C allele and metastatic status. C allele was more common in NSCLC patients. (p=0.04). Conclusion. C allele of FDFT1 rs2645429 polymorphism gene can be a risk factor for NSCLC, whereas T allele probably has a low protective role.http://dx.doi.org/10.1155/2018/4863757 |
| spellingShingle | Mehdi Dehghani Zahra Samani Hassan Abidi Leila Manzouri Reza Mahmoudi Saeed Hosseini Teshnizi Mohsen Nikseresht Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer International Journal of Genomics |
| title | Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer |
| title_full | Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer |
| title_fullStr | Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer |
| title_full_unstemmed | Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer |
| title_short | Relationship of SNP rs2645429 in Farnesyl-Diphosphate Farnesyltransferase 1 Gene Promoter with Susceptibility to Lung Cancer |
| title_sort | relationship of snp rs2645429 in farnesyl diphosphate farnesyltransferase 1 gene promoter with susceptibility to lung cancer |
| url | http://dx.doi.org/10.1155/2018/4863757 |
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