Cross-Reactivity: a Case of Paracetamol-Induced Generalized Bullous Fixed Drug Eruption Followed by Dipyrone-Induced Fixed Drug Eruption
Yuanyuan Wang,1,* Huan Xue,2,* Hejun Dai,1 Lianjuan Yang1 1Department of Medical Mycology, Center of Infectious Skin Diseases, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 2Department of Dermatologic Surgery, Shanghai Ski...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-04-01
|
| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/cross-reactivity-a-case-of-paracetamol-induced-generalized-bullous-fix-peer-reviewed-fulltext-article-CCID |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Yuanyuan Wang,1,* Huan Xue,2,* Hejun Dai,1 Lianjuan Yang1 1Department of Medical Mycology, Center of Infectious Skin Diseases, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China; 2Department of Dermatologic Surgery, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lianjuan Yang, Email lianjuanyang@163.comAbstract: A fixed drug eruption (FDE) is a recurring adverse drug reaction that manifests as lesions on the same cutaneous or mucosal sites after exposure to the causative drug. It is characterized by erythematous or violaceous, round-to-oval patches with a dusky center. With each recurrence, the number and size of lesions can increase, raising the risk for generalized bullous fixed drug eruption (GBFDE). GBFDE, a rare and severe variant, presents with widespread bullae accompanied by characteristic FDE lesions. Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the primary causes of FDE. Although cross-reactivity between different groups of NSAIDs has been rarely reported in FDE cases, in this report we present a case of paracetamol-induced GBFDE followed by FDE triggered by cross-reactivity with dipyrone (metamizole).Keywords: generalized bullous fixed drug eruption, recurrence, paracetamol, dipyrone, cross-reactivity |
|---|---|
| ISSN: | 1178-7015 |