Evaluating the safety, pharmacokinetics and efficacy of phage therapy in treating fracture-related infections with multidrug-resistant Staphylococcus aureus: intravenous versus local application in sheep

Evaluating the safety, pharmacokinetics and efficacy of phage therapy in treating fracture-related infections with multidrug-resistant Staphylococcus aureus: intravenous versus local application in sheep

BackgroundFracture-related infections (FRI), particularly those caused by antibiotic resistant Staphylococcus aureus, present significant clinical challenges due to the formation of biofilm on the implanted device, and reduced options for conventional antibiotic treatment. Bacteriophage (phage) ther...

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Main Authors: Christian Peez, Baixing Chen, Leopold Henssler, Marco Chittò, Jolien Onsea, Michael H. J. Verhofstad, Daniel Arens, Caroline Constant, Stephan Zeiter, William Obremskey, Andrej Trampuz, Michael J. Raschke, Charalampos Zalavras, Willem-Jan Metsemakers, T. Fintan Moriarty
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
bacteriophage
fracture related infection
MRSA
pharmacokinetics
administration
neutralization
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2025.1547250/full
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