Incidence of and Risk Factors for Anti-PD-1/PD-L1- Associated Diarrhea and Colitis: A Retrospective Cohort Study of the Chinese Population
<i>Background and Objectives</i>: The prevalence of and risk factors for immune checkpoint inhibitor-associated diarrhea and colitis (IMDC) in the Chinese population are unclear. This study aimed to estimate IMDC incidence and identify potential risk factors. <i>Materials and Metho...
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2025-02-01
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| author | Wei Chen Yan Wang Mengyu Zhao Hong Zhang Ye Zong Xinyan Zhao |
| author_facet | Wei Chen Yan Wang Mengyu Zhao Hong Zhang Ye Zong Xinyan Zhao |
| author_sort | Wei Chen |
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| description | <i>Background and Objectives</i>: The prevalence of and risk factors for immune checkpoint inhibitor-associated diarrhea and colitis (IMDC) in the Chinese population are unclear. This study aimed to estimate IMDC incidence and identify potential risk factors. <i>Materials and Methods</i>: We reviewed the electronic medical records from Beijing Friendship Hospital (2015–2022) to identify the patients treated with immune checkpoint inhibitors. The primary outcome was IMDC occurrence. The demographics, cancer type, baseline labs, and concurrent medications were analyzed. The univariable and multivariable analyses validated the associated factors. <i>Results</i>: Among 1186 patients (median follow-up: 217 days), the IMDC incidence was 4.6%, with colitis at 0.67%. Digestive system tumors increased the IMDC risk (OR 2.79, 95% CI 1.42–5.75, <i>p</i> = 0.004), while platinum agents decreased it (OR 0.41, 95% CI 0.21–0.78, <i>p</i> = 0.008). PPIs, antibiotics, NSAIDs, and glucocorticoids showed no significant association. Colitis was the third most common irAE, leading to ICI discontinuation (15.6%). <i>Conclusions</i>: IMDC prevalence is 4.6% in the Chinese population, the third most frequent irAE causing ICI discontinuation. Digestive tumors and platinum agents are risk and protective factors, respectively, while other medications show no significant impact. |
| format | Article |
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| language | English |
| publishDate | 2025-02-01 |
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| spelling | doaj-art-9efddbd7ca9b42019be586e9218d1c232025-08-20T03:12:15ZengMDPI AGMedicina1010-660X1648-91442025-02-0161235310.3390/medicina61020353Incidence of and Risk Factors for Anti-PD-1/PD-L1- Associated Diarrhea and Colitis: A Retrospective Cohort Study of the Chinese PopulationWei Chen0Yan Wang1Mengyu Zhao2Hong Zhang3Ye Zong4Xinyan Zhao5Beijing Digestive Disease Center, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaLiver Research Center, National Clinical Research Center for Digestive Disease, Key Laboratory on Translational Medicine on Cirrhosis, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaLiver Research Center, National Clinical Research Center for Digestive Disease, Key Laboratory on Translational Medicine on Cirrhosis, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaDepartment of Pharmacy, Wenzhou Integrated Traditional Chinese and Western Medicine Hospital, Wenzhou 325000, ChinaBeijing Digestive Disease Center, National Clinical Research Center for Digestive Disease, Beijing Key Laboratory for Precancerous Lesion of Digestive Disease, Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, ChinaLiver Research Center, National Clinical Research Center for Digestive Disease, Key Laboratory on Translational Medicine on Cirrhosis, Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China<i>Background and Objectives</i>: The prevalence of and risk factors for immune checkpoint inhibitor-associated diarrhea and colitis (IMDC) in the Chinese population are unclear. This study aimed to estimate IMDC incidence and identify potential risk factors. <i>Materials and Methods</i>: We reviewed the electronic medical records from Beijing Friendship Hospital (2015–2022) to identify the patients treated with immune checkpoint inhibitors. The primary outcome was IMDC occurrence. The demographics, cancer type, baseline labs, and concurrent medications were analyzed. The univariable and multivariable analyses validated the associated factors. <i>Results</i>: Among 1186 patients (median follow-up: 217 days), the IMDC incidence was 4.6%, with colitis at 0.67%. Digestive system tumors increased the IMDC risk (OR 2.79, 95% CI 1.42–5.75, <i>p</i> = 0.004), while platinum agents decreased it (OR 0.41, 95% CI 0.21–0.78, <i>p</i> = 0.008). PPIs, antibiotics, NSAIDs, and glucocorticoids showed no significant association. Colitis was the third most common irAE, leading to ICI discontinuation (15.6%). <i>Conclusions</i>: IMDC prevalence is 4.6% in the Chinese population, the third most frequent irAE causing ICI discontinuation. Digestive tumors and platinum agents are risk and protective factors, respectively, while other medications show no significant impact.https://www.mdpi.com/1648-9144/61/2/353immune checkpoint-associated diarrhea and colitis (IMDC)incidencerisk factorsChinese |
| spellingShingle | Wei Chen Yan Wang Mengyu Zhao Hong Zhang Ye Zong Xinyan Zhao Incidence of and Risk Factors for Anti-PD-1/PD-L1- Associated Diarrhea and Colitis: A Retrospective Cohort Study of the Chinese Population Medicina immune checkpoint-associated diarrhea and colitis (IMDC) incidence risk factors Chinese |
| title | Incidence of and Risk Factors for Anti-PD-1/PD-L1- Associated Diarrhea and Colitis: A Retrospective Cohort Study of the Chinese Population |
| title_full | Incidence of and Risk Factors for Anti-PD-1/PD-L1- Associated Diarrhea and Colitis: A Retrospective Cohort Study of the Chinese Population |
| title_fullStr | Incidence of and Risk Factors for Anti-PD-1/PD-L1- Associated Diarrhea and Colitis: A Retrospective Cohort Study of the Chinese Population |
| title_full_unstemmed | Incidence of and Risk Factors for Anti-PD-1/PD-L1- Associated Diarrhea and Colitis: A Retrospective Cohort Study of the Chinese Population |
| title_short | Incidence of and Risk Factors for Anti-PD-1/PD-L1- Associated Diarrhea and Colitis: A Retrospective Cohort Study of the Chinese Population |
| title_sort | incidence of and risk factors for anti pd 1 pd l1 associated diarrhea and colitis a retrospective cohort study of the chinese population |
| topic | immune checkpoint-associated diarrhea and colitis (IMDC) incidence risk factors Chinese |
| url | https://www.mdpi.com/1648-9144/61/2/353 |
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