Integration and functionality of human iPSC-derived microglia in a chimeric mouse retinal model

Integration and functionality of human iPSC-derived microglia in a chimeric mouse retinal model

Abstract Introduction Microglia, the resident immune cells of the central nervous system, play a pivotal role in maintaining homeostasis, responding to injury, and modulating neuroinflammation. However, the limitations of rodent models in accurately representing human microglia have posed significan...

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Main Authors: Chun Tang, Qi-Qi Zhou, Xiu-Feng Huang, Ya-Yi Ju, Bi-Lin Rao, Zhi-Cong Liu, Yi-An Jia, Zhan-Pei Bai, Qing-Yang Lin, Lin Liu, Jia Qu, Jun Zhang, Mei-Ling Gao
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Xenotransplantation
HiPSCs
Retinal explant
Chimeric
Online Access:https://doi.org/10.1186/s12974-025-03393-8
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