Acinetobacter baumannii Infection and IL-17 Mediated Immunity
Acinetobacter baumannii is a significant cause of severe hospital-acquired infections with a recent rise in multidrug-resistant infections involving traumatic wounds of military personnel. The interleukin-17 (IL-17) pathway is essential for neutrophil recruitment in response to a variety of pathogen...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2016/9834020 |
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| _version_ | 1849398165151678464 |
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| author | Zihe Yan Junjun Yang Renjing Hu Xichi Hu Kong Chen |
| author_facet | Zihe Yan Junjun Yang Renjing Hu Xichi Hu Kong Chen |
| author_sort | Zihe Yan |
| collection | DOAJ |
| description | Acinetobacter baumannii is a significant cause of severe hospital-acquired infections with a recent rise in multidrug-resistant infections involving traumatic wounds of military personnel. The interleukin-17 (IL-17) pathway is essential for neutrophil recruitment in response to a variety of pathogens, while the control of A. baumannii infection is known to be dependent on neutrophils. This suggests that IL-17 may play an important role in A. baumannii infection; however, this has yet to be studied. Here, we summarize the recent advances in understanding the host-pathogen interaction of A. baumannii and propose a potential role of the IL-17 pathway in generating a protective immune response. |
| format | Article |
| id | doaj-art-9efcfd810dcb45ffbc47c26b2739a937 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-9efcfd810dcb45ffbc47c26b2739a9372025-08-20T03:38:43ZengWileyMediators of Inflammation0962-93511466-18612016-01-01201610.1155/2016/98340209834020Acinetobacter baumannii Infection and IL-17 Mediated ImmunityZihe Yan0Junjun Yang1Renjing Hu2Xichi Hu3Kong Chen4Department of Clinical Laboratory, The Affiliated Wuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangsu 214002, ChinaDepartment of Clinical Laboratory, The Affiliated Wuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangsu 214002, ChinaDepartment of Clinical Laboratory, The Affiliated Wuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangsu 214002, ChinaDepartment of Clinical Laboratory, The Affiliated Wuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangsu 214002, ChinaRichard King Mellon Foundation Institute for Pediatric Research, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USAAcinetobacter baumannii is a significant cause of severe hospital-acquired infections with a recent rise in multidrug-resistant infections involving traumatic wounds of military personnel. The interleukin-17 (IL-17) pathway is essential for neutrophil recruitment in response to a variety of pathogens, while the control of A. baumannii infection is known to be dependent on neutrophils. This suggests that IL-17 may play an important role in A. baumannii infection; however, this has yet to be studied. Here, we summarize the recent advances in understanding the host-pathogen interaction of A. baumannii and propose a potential role of the IL-17 pathway in generating a protective immune response.http://dx.doi.org/10.1155/2016/9834020 |
| spellingShingle | Zihe Yan Junjun Yang Renjing Hu Xichi Hu Kong Chen Acinetobacter baumannii Infection and IL-17 Mediated Immunity Mediators of Inflammation |
| title | Acinetobacter baumannii Infection and IL-17 Mediated Immunity |
| title_full | Acinetobacter baumannii Infection and IL-17 Mediated Immunity |
| title_fullStr | Acinetobacter baumannii Infection and IL-17 Mediated Immunity |
| title_full_unstemmed | Acinetobacter baumannii Infection and IL-17 Mediated Immunity |
| title_short | Acinetobacter baumannii Infection and IL-17 Mediated Immunity |
| title_sort | acinetobacter baumannii infection and il 17 mediated immunity |
| url | http://dx.doi.org/10.1155/2016/9834020 |
| work_keys_str_mv | AT ziheyan acinetobacterbaumanniiinfectionandil17mediatedimmunity AT junjunyang acinetobacterbaumanniiinfectionandil17mediatedimmunity AT renjinghu acinetobacterbaumanniiinfectionandil17mediatedimmunity AT xichihu acinetobacterbaumanniiinfectionandil17mediatedimmunity AT kongchen acinetobacterbaumanniiinfectionandil17mediatedimmunity |