Combination decoction of Astragalus mongholicus and Salvia miltiorrhiza mitigates pressure-overload cardiac dysfunction by inhibiting multiple ferroptosis pathways

Combination decoction of Astragalus mongholicus and Salvia miltiorrhiza mitigates pressure-overload cardiac dysfunction by inhibiting multiple ferroptosis pathways

BackgroundAstragalus mongholicus (AM) and Salvia miltiorrhiza (SM) are commonly used in traditional Chinese medicine to treat heart failure (HF). Ferroptosis has been studied as a key factor in the occurrence of HF. It remains unclear whether the combined use of AM and SM can effectively improve HF...

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Main Authors: Qiyao Xu, Xuan Liu, Zhaoyang Chen, Can Guo, Pengyu Lu, Sujie Zhang, Xindong Wang, Jianping Shen
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Pharmacology
Subjects:
ferroptosis
heart failure
Astragalus mongholicus
Salvia miltiorrhiza
GPX4
FSP1
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1447546/full
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