Immunomodulation by 4-Hydroxy-TEMPO (TEMPOL) and Dimethyl Fumarate (DMF) After Ventral Root Crush (VRC) in C57BL/6J Mice: A Flow Cytometry Analysis

Immunomodulation by 4-Hydroxy-TEMPO (TEMPOL) and Dimethyl Fumarate (DMF) After Ventral Root Crush (VRC) in C57BL/6J Mice: A Flow Cytometry Analysis

Spinal motor nerve root lesions can happen after avulsion or crush, generating acute motoneuron death and synaptic loss, consequently, causing motor and sensory dysfunctions. Local response is mediated by astroglial and microglial cells, giving rise to a pro-inflammatory profile. TEMPOL and DMF are...

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Bibliographic Details
Main Authors: Maria Fernanda Vannucci Balzani, Lilian de Oliveira Coser, Alexandre Leite Rodrigues de Oliveira
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Biology
Subjects:
flow cytometry
ventral root lesion
immunoinflammation
Online Access:https://www.mdpi.com/2079-7737/14/5/473
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